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costanza

16.02.2009, 11:49
 

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17 (Hair Multiplication & Stem Cells Treatment)

http://www.prweb.com/releases/Histogen/Hairtrial/prweb2069524.htm

New York (PRWEB) February 16, 2009 -- Dr. Gail Naughton, CEO of Histogen, Inc., a regenerative medicine company developing solutions based on the products of newborn fibroblasts grown under embryonic conditions, will address attendees tomorrow at the 4th Annual Stem Cell Summit in New York. Dr. Naughton will be presenting preliminary mid-trial results from Histogen's first human clinical evaluation of ReGenicaTM for hair regrowth.

The primary objective of this double-blind, placebo-controlled, randomized study is to evaluate safety in the clinical application of the ReGenica product for hair regrowth. Histogen is also examining product efficacy as a secondary objective, specifically looking at the same end-points the Company has seen in the animal model - new hair growth, and the thickness of new and existing hair. The study is in progress, but the Company has reviewed data from the scheduled 12 week time point and is pleased with the results to date.

"Histogen's clinical trial was designed to assess the safety of its product over a five month period," commented Dr. Craig Ziering, principal investigator of the study and founder of Ziering Medical. "In addition to seeing no adverse reactions, we were delighted to see more hair, thicker hair shafts, and what appears to be the growth of completely new hair follicles in the areas that received the ReGenica treatment."

ReGenica is a proprietary liquid formula created by the culturing of newborn fibroblasts in an embryonic-like environment, and then harvesting the naturally secreted embryonic wnt proteins, growth factors, and other synergistic bioproducts that are produced. It is the first naturally stabilized and bioactive formulation of wnt proteins and natural cofactors, which are thought to act in the formation of new hair follicles.

"Wnt signaling has been shown to be responsible for initiating epidermal stem cells to form new hair follicles in mice, and is also important in maintaining the hair inducing activity from existing follicles," said Frank Zeigler, General Manager at Histogen. "We are excited to be the first group to show these effects in a clinical setting using human WNT proteins."

Histogen began this outside-U.S. study of ReGenica for hair regrowth in November, with the goal of more rapidly obtaining human safety data which will allow the Company to progress with product development. The trial is currently ongoing, and Histogen expects to release full results from this first clinical study in the first half of 2009.

Dr. Gail Naughton has spent more than 15 years extensively researching the tissue engineering process, and holds more than 90 patents in the field. Dr. Naughton founded Histogen in 2007, and currently serves as Chief Executive Officer and Chairman of the Board for the Company, in addition to her position as Dean of the College of Business at San Diego State University.

BEFORE
[image]

AFTER 12 WEEKS
[image]

SIDE BY SIDE COMPARISON
[image]




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Post reply
nemo.shark

22.04.2012, 15:04

@ Max

Two versions of ReGenica??

Has anyone emailed histogen lately to ask them for an estimate of when the injection may be ready for public release?

I know two years ago they were saying it would be two to three years minimum for release in asia.




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Post reply
Ahab

14.04.2012, 21:32

@ gutted2

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

» i thought hair transplants are permanent? or do they start minitarising
» too??

1) Transplanted hairs don't always grow after being transplanted. Sometimes none of the transplanted hairs every grow hair. Major bummer. The transplant doctor just shrugs like, "don't look at me--sometimes sh#t happens."

2) Eventually, sooner or later, there's a good chance if transplanted hairs do grow after being transplanted, they will eventually grow less and less robust hairs, and possibly cease growing hair altogether because even so-called "permanent" hair in the donor area can be subject to male pattern baldness in the form of diffuse thinning.

Just look closely at bald older guys, and you will see that the remaining hair on the back and sides of their heads is often see-through.




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Post reply
gutted2

14.04.2012, 15:31

@ MikadoMan

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

» Yes 2020 ironman hd multiple FUt sessions done and had no growth in the
» recipientarea andhis donor is totally f****** but he keeps on insulting
» everyone, you know he rejects reality and creates his own :-D
»
» and this guy with hi thousand missing or destroyed follicles is mocking
» others :-)
»
» so dont take him seriously this guy is turning 50 soon and he still acts
» like a total dbag. i mean he always says he doesnt care about hair loss but
» why is he still lurking here at makes screencaps at other forums?
»
» i give you a hint here, you can have a lot of fun with this guy like i have
» it becaue he always does what you want him to do


i thought hair transplants are permanent? or do they start minitarising too??




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Post reply
MikadoMan

14.04.2012, 14:24

@ Iron_Man

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

Yes 2020 ironman hd multiple FUt sessions done and had no growth in the recipientarea andhis donor is totally f****** but he keeps on insulting everyone, you know he rejects reality and creates his own :-D

and this guy with hi thousand missing or destroyed follicles is mocking others :-)

so dont take him seriously this guy is turning 50 soon and he still acts like a total dbag. i mean he always says he doesnt care about hair loss but why is he still lurking here at makes screencaps at other forums?

i give you a hint here, you can have a lot of fun with this guy like i have it becaue he always does what you want him to do




MikadoMan is located in [NA] and he is available to meet: NO

---
You wanna get all the answers why none of your "ethical" clinics have adopted Ghos HST hairmuliplication so far?

THEN READ THIS http://www.hairsite.com/hair-loss/img/uploaded_files/2879_file32.pdf


Post reply
Iron_Man

14.04.2012, 13:40

@ 2020

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

» seriously.... why do you bump this thread?

Why? So that idiots like you can read how other idiots like you in 2009 "analyzed" BS "proof photos".




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
2020

14.04.2012, 13:32

@ Iron_Man

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

» » Right, because drawing parallels between two TOTALLY DIFFERENT
» INDUSTRIES
» » is a perfectly logical way to construct a cogent argument.
» »
» » What Europe has contributed to hairloss research:
» »
» » 1. Gho
» » 2. ICX
» » 3. That wackjob from Oxford [Whitfield]
» »
» » What the States has contributed:
» »
» » 1. Follica
» » 2. Aderans (Japanese company, US researcher)
» » 3. Histogen
»
» hmmmm...


seriously.... why do you bump this thread?

"oh look guys histogen hasn't posted anything new in > 6 months haha I told you it will fail"

you idiot, they're Phase 2 lasts up until December...




2020 is located in [NA] and he is available to meet: NO


Post reply
MikadoMan

14.04.2012, 13:20

@ Iron_Man

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

Three failed FUT surgeries 15.000 US Dollar

Internet and PC 500 Dollar

being an idiot and bump threads from 2009 because you have no life PRICELESS




MikadoMan is located in [NA] and he is available to meet: NO

---
You wanna get all the answers why none of your "ethical" clinics have adopted Ghos HST hairmuliplication so far?

THEN READ THIS http://www.hairsite.com/hair-loss/img/uploaded_files/2879_file32.pdf


Post reply
Iron_Man

14.04.2012, 12:47

@ fckhrls

Histogen Preliminary Hair Regrowth Clinical Results to be Presented Feb 17

» Right, because drawing parallels between two TOTALLY DIFFERENT INDUSTRIES
» is a perfectly logical way to construct a cogent argument.
»
» What Europe has contributed to hairloss research:
»
» 1. Gho
» 2. ICX
» 3. That wackjob from Oxford [Whitfield]
»
» What the States has contributed:
»
» 1. Follica
» 2. Aderans (Japanese company, US researcher)
» 3. Histogen

hmmmm...




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
TheOne

22.02.2009, 09:58

@ Max

you are right.

» » » Someone know,when histogen begin withe the trail 2?
» » » It looks to good,that we wait to 2015
» »
» »
» » I didn't know anything about Histogen until I entered this thread.
» » I don't know when Phase II will begin, but I will watch with interest
» » Phase I evolution, e.g. photos at 6 months.
»
»
» I know,Histogen make the trails not in the USA!
» I think they have not so much bureaucratic requirements.
» It must go faster then Ari or hmmmmmmmmmmmm....(Tr....:-) )

It says in the pdf that phase I will last 5 months, they are already about 3 months in.

From the pdf:

Next Steps in Hair Growth

•5 month follow up
-Clinical macrophotography (follicle counts)
-2mm punch biopsies
-Subject self assessment questionnaire
•Meeting with FDA-CBER
•Series B financing for establishment of GMP manufacturing facility completion/validation
Clinical trial for use of ReGenica for maintenance of hair follicle retention post transplantation
•Clinical trial for topical application of ReGenica-hair growth and thickening
•US Phase I/II clinical trial for hair growth stimulation





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Post reply
Max

22.02.2009, 06:52

@ Spanish Dude

you are right.

» » Someone know,when histogen begin withe the trail 2?
» » It looks to good,that we wait to 2015
»
»
» I didn't know anything about Histogen until I entered this thread.
» I don't know when Phase II will begin, but I will watch with interest
» Phase I evolution, e.g. photos at 6 months.


I know,Histogen make the trails not in the USA!
I think they have not so much bureaucratic requirements.
It must go faster then Ari or hmmmmmmmmmmmm....(Tr....:-) )




Max is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

21.02.2009, 13:23

@ Max

you are right.

» Someone know,when histogen begin withe the trail 2?
» It looks to good,that we wait to 2015


I didn't know anything about Histogen until I entered this thread.
I don't know when Phase II will begin, but I will watch with interest Phase I evolution, e.g. photos at 6 months.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Max

21.02.2009, 08:15

@ Spanish Dude

you are right.

» » No, I don't think it's in Histogen's treatment. It's in Lumigan (the
» » treatment for glaucoma) and in Latisse (that eyelash lengthening
» » prescription medication). It's a prostamide which have been shown to be
» » somewhat effective in growing hair in balding macacques. And, like I
» said,
» » it increases melanin synthesis, too.
» »
» » I'd try the Latisse stuff if it ever came out as a foam or whatever for
» » hair loss. But haven't heard anything really.
»
» ok, I see now, that there could be a link between enhancing pigmentation
» and regrowing hair. Lets see if we can get both problems solved together.


Someone know,when histogen begin withe the trail 2?
It looks to good,that we wait to 2015




Max is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

21.02.2009, 06:52

@ Slime707

you are right.

» No, I don't think it's in Histogen's treatment. It's in Lumigan (the
» treatment for glaucoma) and in Latisse (that eyelash lengthening
» prescription medication). It's a prostamide which have been shown to be
» somewhat effective in growing hair in balding macacques. And, like I said,
» it increases melanin synthesis, too.
»
» I'd try the Latisse stuff if it ever came out as a foam or whatever for
» hair loss. But haven't heard anything really.

ok, I see now, that there could be a link between enhancing pigmentation and regrowing hair. Lets see if we can get both problems solved together.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Slime707

20.02.2009, 18:57

@ Spanish Dude

you are right.

No, I don't think it's in Histogen's treatment. It's in Lumigan (the treatment for glaucoma) and in Latisse (that eyelash lengthening prescription medication). It's a prostamide which have been shown to be somewhat effective in growing hair in balding macacques. And, like I said, it increases melanin synthesis, too.

I'd try the Latisse stuff if it ever came out as a foam or whatever for hair loss. But haven't heard anything really.




Slime707 is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

20.02.2009, 18:30

@ cal

you are right.

» »
» » So, if the "after" photo has darker hairs, this could mean that
» » melanocytes have been boosted. So, this could prevent the onset of gray
» » hair, and even correct it.
»
» I've been saying this for a long time.
»
» IMHO when they finally come up with something that actually restarts
» follicles, it very may well restore graying color along with it.
»
»
» They think the potential profits (from the MPB market alone) are big right
» now . . .


Indeed, just as grayhair treatment, would be a winner.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

20.02.2009, 18:21

@ Slime707

you are right.

» Bimatoprost increases melanin production. I wonder if that would have any
» effect on grey hair....

what is bimatoprost? is that a component in Histogen?




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Slime707

20.02.2009, 18:16

@ Spanish Dude

you are right.

Bimatoprost increases melanin production. I wonder if that would have any effect on grey hair....




Slime707 is located in [NA] and he is available to meet: NO


Post reply
cal

20.02.2009, 18:15

@ Spanish Dude

you are right.

»
» So, if the "after" photo has darker hairs, this could mean that
» melanocytes have been boosted. So, this could prevent the onset of gray
» hair, and even correct it.

I've been saying this for a long time.

IMHO when they finally come up with something that actually restarts follicles, it very may well restore graying color along with it.


They think the potential profits (from the MPB market alone) are big right now . . .




cal is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

20.02.2009, 17:59

@ Slime707

you are right.

» » Well, yes, it is possible that this drug enhances pigmentation. in that
» » case, cheers for them. But it is really surprising.
»
» » but some of them are like made of glass!!
»
» I'm not saying this works or not, but isn't one of the signs of a
» treatment working the fact that existing hairs become darker? MPB is often
» associated with the lightening of hair pigmentation.
»
» And to say the hairs are transparent......do yourself a favour and get a
» USB microscope or something (pretty cheap) with a 200x zoom or so and have
» a look the hairs on your scalp. What you'll see is that they too look
» fairly 'transparent' but clearly when you look at them with the naked eye
» they don't. Did you never look at a strand of hair with a microscope at
» school??!!

Ok, you are right. My bad. I didn't know.


googling:
>>>
In general, the more melanin present, the darker the hair color; the less melanin, the lighter the hair color.

When these Melanocytes stop producing the pigment the result is a transparent hair. The transparent hair against your healthier darker hair gives the appearance of Gray hair. In reality the hair is not Gray but transparent.
<<<

So, if the "after" photo has darker hairs, this could mean that melanocytes have been boosted. So, this could prevent the onset of gray hair, and even correct it.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Slime707

20.02.2009, 17:26

@ Spanish Dude

Transparent hairs???

» Well, yes, it is possible that this drug enhances pigmentation. in that
» case, cheers for them. But it is really surprising.

» but some of them are like made of glass!!

I'm not saying this works or not, but isn't one of the signs of a treatment working the fact that existing hairs become darker? MPB is often associated with the lightening of hair pigmentation.

And to say the hairs are transparent......do yourself a favour and get a USB microscope or something (pretty cheap) with a 200x zoom or so and have a look the hairs on your scalp. What you'll see is that they too look fairly 'transparent' but clearly when you look at them with the naked eye they don't. Did you never look at a strand of hair with a microscope at school??!!




Slime707 is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

20.02.2009, 15:18

@ p

Transparent hairs???

» » Both photos are taken at the same scale-distance-zoom. No problem here.
»
» How can you be sure? What did you do to verify?

I used the animated gif to find out what points of one photo correspond to what points in the other photo. And I see that the distances are exactly the same.

»
» » Have you noticed that in the "after" photo, hairs are much darker?
»
» Yep.
»
» » This cannot be an effect of the drug,
»
» Why not? If it increases pigmentation hairs would be darker. One thing I
» was thinking about was the tendency of some topicals to taint the hair,
» thus incorrectly making them appear thicker and more pigmented. Folligen
» has this "toppik-like" quality to some degree, as do some other topicals.
» It would be preferable if photos were after about two days without
» treament, the subject having washed his hair one or twice in the meantime.

Well, yes, it is possible that this drug enhances pigmentation. in that case, cheers for them. But it is really surprising.

»
» » And have you noticed that hairs are a bit transparent? Sometimes you
» can
» » see through a hair, another hair that is behind.
»
» That seems right to me. I'm not surprised a small hair without much
» pigmentation under a bright light would appear slightly transparent.

but some of them are like made of glass!!
[image]




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
p

20.02.2009, 07:28

@ Spanish Dude

Transparent hairs???

» Both photos are taken at the same scale-distance-zoom. No problem here.

How can you be sure? What did you do to verify?

» Have you noticed that in the "after" photo, hairs are much darker?

Yep.

» This cannot be an effect of the drug,

Why not? If it increases pigmentation hairs would be darker. One thing I was thinking about was the tendency of some topicals to taint the hair, thus incorrectly making them appear thicker and more pigmented. Folligen has this "toppik-like" quality to some degree, as do some other topicals. It would be preferable if photos were after about two days without treament, the subject having washed his hair one or twice in the meantime.

» And have you noticed that hairs are a bit transparent? Sometimes you can
» see through a hair, another hair that is behind.

That seems right to me. I'm not surprised a small hair without much pigmentation under a bright light would appear slightly transparent.




p is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

20.02.2009, 06:38

@ p

Transparent hairs???

Both photos are taken at the same scale-distance-zoom. No problem here.
Have you noticed that in the "after" photo, hairs are much darker?
This cannot be an effect of the drug, but due to different photo conditions.

And have you noticed that hairs are a bit transparent? Sometimes you can see through a hair, another hair that is behind.
This happens both in the before and after photo, but its more evident in the before photo.

click to enlarge:

[image]


» » Also, the second photo was purportedly taken 12 weeks after the first.
» Am
» » I alone in thinking that scalp hair would grow significantly longer in
» 12
» » weeks than what appears in the second photo? I think it was cut back,
» just
» » not to the exact same length as in the original photo, perhaps
» » intentionally.
» »
» » True comparison photos for an experiment like this should have involved
» » taking a picture immediately after a buzz cut with a zero or one-guard
» as a
» » control photo, and then again twelve weeks later, with the same
» » blade/guard, of the exact same spot, so the pictures could be
» superimposed
» » for a more accurate comparision.
»
» Good point! I am tempted to retouch the second photo and make the hairs as
» long as in the first picture on average. That would give us a better
» indication of the real, unbiased results. Actally one should also compare
» the mean size of the marks on the skin and scale the second picture until
» it matches. As it is now, it is a bit difficult to know if the apparent
» increase in thickness is due to different camera distance in part.
»
» Anyway, I actually think they are on to something here.




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Post reply
nsmnyc

19.02.2009, 15:18

@ fckhrls

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

» »
» » I have direct info from them, and I was told that they had 24 subjects,
» » allof which experienced improvement in hair follicles, as well as new
» hair
» » growth.
»
» How did you get the info?

Called them, talked to the CEO.




nsmnyc is located in [NA] and he is available to meet: NO


Post reply
p

18.02.2009, 21:21

@ ESP2

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

» Also, the second photo was purportedly taken 12 weeks after the first. Am
» I alone in thinking that scalp hair would grow significantly longer in 12
» weeks than what appears in the second photo? I think it was cut back, just
» not to the exact same length as in the original photo, perhaps
» intentionally.
»
» True comparison photos for an experiment like this should have involved
» taking a picture immediately after a buzz cut with a zero or one-guard as a
» control photo, and then again twelve weeks later, with the same
» blade/guard, of the exact same spot, so the pictures could be superimposed
» for a more accurate comparision.

Good point! I am tempted to retouch the second photo and make the hairs as long as in the first picture on average. That would give us a better indication of the real, unbiased results. Actally one should also compare the mean size of the marks on the skin and scale the second picture until it matches. As it is now, it is a bit difficult to know if the apparent increase in thickness is due to different camera distance in part.

Anyway, I actually think they are on to something here.




p is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

18.02.2009, 19:35

@ ESP2

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

True. In 3 months, hair grows 1.5 inches= 3.8 cm, longer than what appears in the "after" photo.
So they trimmed it back, but not as short as in the "before" photo. This is very stupid and misleading, I think.



» Also, the second photo was purportedly taken 12 weeks after the first. Am
» I alone in thinking that scalp hair would grow significantly longer in 12
» weeks than what appears in the second photo? I think it was cut back, just
» not to the exact same length as in the original photo, perhaps
» intentionally.
»
» True comparison photos for an experiment like this should have involved
» taking a picture immediately after a buzz cut with a zero or one-guard as a
» control photo, and then again twelve weeks later, with the same
» blade/guard, of the exact same spot, so the pictures could be superimposed
» for a more accurate comparision.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
fckhrls

18.02.2009, 18:59

@ nsmnyc

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

»
» I have direct info from them, and I was told that they had 24 subjects,
» allof which experienced improvement in hair follicles, as well as new hair
» growth.

How did you get the info?




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Post reply
Sceptic

18.02.2009, 18:34

@ nsmnyc

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

» I have direct info from them

et's you mean ? how are they ? do they bald ? Exciting !!!




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Post reply
nsmnyc

18.02.2009, 15:22

@ ESP2

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

» Also, the second photo was purportedly taken 12 weeks after the first. Am
» I alone in thinking that scalp hair would grow significantly longer in 12
» weeks than what appears in the second photo? I think it was cut back, just
» not to the exact same length as in the original photo, perhaps
» intentionally.
»
» True comparison photos for an experiment like this should have involved
» taking a picture immediately after a buzz cut with a zero or one-guard as a
» control photo, and then again twelve weeks later, with the same
» blade/guard, of the exact same spot, so the pictures could be superimposed
» for a more accurate comparision.

I have direct info from them, and I was told that they had 24 subjects, allof which experienced improvement in hair follicles, as well as new hair growth. To which outside experts say is unheard of, and 2/24 would have been considered good news. Especially since it was a 1mg? injection, and only to test safety. It can only get better from here in phase II. As well, think of this, has any of the other companies experienced these kind of results in Phase I?None of them, so I think they have the greatest progress and results as of yet. As well, they have other cosmetic products ready to go to market so they can bring cash in to support their research. They do need funding though in these tough economic times where creditors are being tight. So if you want to invest, with potential gain, as well as in something that has a direct impact to your own well being. Contact them now, seriously.




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Post reply
ESP2

E-mail

18.02.2009, 11:26

@ Spanish Dude

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

Also, the second photo was purportedly taken 12 weeks after the first. Am I alone in thinking that scalp hair would grow significantly longer in 12 weeks than what appears in the second photo? I think it was cut back, just not to the exact same length as in the original photo, perhaps intentionally.

True comparison photos for an experiment like this should have involved taking a picture immediately after a buzz cut with a zero or one-guard as a control photo, and then again twelve weeks later, with the same blade/guard, of the exact same spot, so the pictures could be superimposed for a more accurate comparision.




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Post reply
moomin

18.02.2009, 10:07

@ Max

Two versions of ReGenica??

Looking at the website, they appear to be the same product.

Perhaps it's like Proscar and Propecia, in that even though they both use the same ingredient, they had to go through two sets of trials in order to legitimately market the product as suitable for a skin care range and a hair care range.

If this is the case, it might bear even better results if coupled with wounding.

Intresting stuff




moomin is located in [NA] and he is available to meet: NO


Post reply
TheOne

18.02.2009, 09:52

@ ymail

Two versions of ReGenica??

» » » On their site, Histogen lists two versions of ReGenica. One for skin
» » care
» » » (to be launched this year) and other for Hair Care (to be launched
» » 2015).
» » » Usually different products have different names, so is this a same
» » product
» » » or two different formulations?
» »
» » From the preliminary research that I've done. ReGenica for Skin care is
» a
» » topical product, whereas ReGenica for Hair Regrowth is an injectible.
» Other
» » than that, they are the same thing. Can anyone verify that?
» »
» » If ReGeneica injections actually work then topical should have some
» effect
» » too. The topical will be out within few months, so we will be able to
» give
» » it a shot.
»
» That's interesting. If we can find that these products are the same, we
» can use the topical form in our homemade follica trials, as a topical wnt
» booster.

If they are the same then they are going to be very expensive.
Histogen said it would recomend a price of $5000 for the hair loss treatment, so if they are the same thing I don't see how the skin version could be much cheaper.

It's also interesting that in the trial they tried microdermabration before injecting.




TheOne is located in [NA] and he is available to meet: NO


Post reply
ymail

18.02.2009, 08:40

@ goata007

Two versions of ReGenica??

» » On their site, Histogen lists two versions of ReGenica. One for skin
» care
» » (to be launched this year) and other for Hair Care (to be launched
» 2015).
» » Usually different products have different names, so is this a same
» product
» » or two different formulations?
»
» From the preliminary research that I've done. ReGenica for Skin care is a
» topical product, whereas ReGenica for Hair Regrowth is an injectible. Other
» than that, they are the same thing. Can anyone verify that?
»
» If ReGeneica injections actually work then topical should have some effect
» too. The topical will be out within few months, so we will be able to give
» it a shot.

That's interesting. If we can find that these products are the same, we can use the topical form in our homemade follica trials, as a topical wnt booster.




ymail is located in [NA] and he is available to meet: NO


Post reply
Max

18.02.2009, 05:39

@ goata007

Two versions of ReGenica??

» On their site, Histogen lists two versions of ReGenica. One for skin care
» (to be launched this year) and other for Hair Care (to be launched 2015).
» Usually different products have different names, so is this a same product
» or two different formulations?


Do you think,it is the same?




Max is located in [NA] and he is available to meet: NO


Post reply
goata007

18.02.2009, 02:45

@ goata007

Two versions of ReGenica??

» On their site, Histogen lists two versions of ReGenica. One for skin care
» (to be launched this year) and other for Hair Care (to be launched 2015).
» Usually different products have different names, so is this a same product
» or two different formulations?

From the preliminary research that I've done. ReGenica for Skin care is a topical product, whereas ReGenica for Hair Regrowth is an injectible. Other than that, they are the same thing. Can anyone verify that?

If ReGeneica injections actually work then topical should have some effect too. The topical will be out within few months, so we will be able to give it a shot.




goata007 is located in [NA] and he is available to meet: NO

---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein


Post reply
FightingFalcon

18.02.2009, 02:17

@ goata007

12 Weeks

For all the treatments known today, 12 weeks is approx. the minimum time period where any hair growth treatment just begins to show its effects.




FightingFalcon is located in [NA] and he is available to meet: NO


Post reply
goata007

18.02.2009, 00:47

@ Spanish Dude

Two versions of ReGenica??

On their site, Histogen lists two versions of ReGenica. One for skin care (to be launched this year) and other for Hair Care (to be launched 2015). Usually different products have different names, so is this a same product or two different formulations?




goata007 is located in [NA] and he is available to meet: NO

---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein


Post reply
Spanish Dude

17.02.2009, 21:43

@ TheOne

First time ever any hairloss researcher publishes photos

» » Thanks TheOne. This article is very good.
» » 15%-20% hair increase in the best patients.
» » Yes, sounds credible, after analyzing the hi-res photos.
» » We will see if they can improve results. So far, they are vey poor.
» »
»
»
» Don't forget its only at the phase I satage, it is usually a safety trial
» so small doses are used.
» Maybe if they can increase the amount they inject when looking for better
» eficacy the results will improve.
» This is only at 12 weeks aswell remember.

Yes, lets hope for the best.
Also, the fact that they have published a hi-res photo is a big plus, and its THE FIRST TIME EVER ANY HAIRLOSS RESEARCHER PUBLISHES PHOTOS. I don't understand why they didn't publish the photos in a proper manner (i.e, easy comparable) but anyway, I am happy.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
dave21

17.02.2009, 20:46

@ jaymac

15%-20% at best

Well for a product that comes out in 2015 and has basically the results of minox....this isn't good.




dave21 is located in [NA] and he is available to meet: NO


Post reply
TheOne

17.02.2009, 20:37

@ Spanish Dude

15%-20% at best

» Thanks TheOne. This article is very good.
» 15%-20% hair increase in the best patients.
» Yes, sounds credible, after analyzing the hi-res photos.
» We will see if they can improve results. So far, they are vey poor.
»


Don't forget its only at the phase I satage, it is usually a safety trial so small doses are used.
Maybe if they can increase the amount they inject when looking for better eficacy the results will improve.
This is only at 12 weeks aswell remember.




TheOne is located in [NA] and he is available to meet: NO


Post reply
jaymac

17.02.2009, 20:26

@ fckhrls

15%-20% at best

» » Thanks TheOne. This article is very good.
» » 15%-20% hair increase in the best patients.
» » Yes, sounds credible, after analyzing the hi-res photos.
» » We will see if they can improve results. So far, they are vey poor.
»
» I'd be happy with a 10% improvement if it could be achieved reliably.

big time. even if there was absolutely no new hairs and at absolute very best it improved thinning hairs by 30 or 40% Aesthetically this would be a major result.




jaymac is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

17.02.2009, 20:24

@ fckhrls

15%-20% at best

» » Thanks TheOne. This article is very good.
» » 15%-20% hair increase in the best patients.
» » Yes, sounds credible, after analyzing the hi-res photos.
» » We will see if they can improve results. So far, they are vey poor.
»
» I'd be happy with a 10% improvement if it could be achieved reliably.

I wouldn't. 10% is crap.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
fckhrls

17.02.2009, 20:04

@ Spanish Dude

15%-20% at best

» Thanks TheOne. This article is very good.
» 15%-20% hair increase in the best patients.
» Yes, sounds credible, after analyzing the hi-res photos.
» We will see if they can improve results. So far, they are vey poor.

I'd be happy with a 10% improvement if it could be achieved reliably.




fckhrls is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

17.02.2009, 19:49

@ TheOne

15%-20% at best

Thanks TheOne. This article is very good.
15%-20% hair increase in the best patients.
Yes, sounds credible, after analyzing the hi-res photos.
We will see if they can improve results. So far, they are vey poor.


» http://www3.signonsandiego.com/stories/2009/feb/17/1b17hair213536-biotech-excited-about-hair-growth-r/
»
» If your forehead is more like a fivehead, or you've started to see a lot
» more scalp at the crown of your head, the tiny San Diego biotechnology
» company Histogen has some promising news.
» The company today is unveiling preliminary results from an early-stage
» clinical trial that showed its experimental hair regrowth therapy,
» ReGenica, increased new hair growth and the thickness of existing hair in
» men after 12 weeks.
» “These results appear to be phenomenal, although this trial is still in
» the very early stages,” said Los Angeles-based hair transplant
» specialist Dr. Craig Ziering.
» “Wimpy hairs became thicker, which is pretty significant to the patient
» because even if you cannot increase the numbers of hairs, if you increase
» the diameter, you increase the volume. And preliminary hair
» counts show there was an increase in new hair of 15 to 20 percent in some
» patients,”
said Ziering, a paid member of the company's
» scientific advisory board.
» ReGenica is made of a cocktail of proteins that are present in the
» early-stage embryo and help direct stem cells to become either hair, bone
» or blood, said Histogen Chief Executive Gail Naughton.
» Although scientists have known about the role these proteins play,
» Histogen's aha moment was figuring out how to create them in a lab, said
» Naughton, who is also dean of San Diego State University's School of
» Business Administration.
» Fibroblasts, early-stage stem cells that form connective tissue, are grown
» in the simulated low-oxygen and free-floating, low-gravity conditions of
» the embryo, Naughton said. The important Wnt proteins and growth factors
» then build up in that environment, she said.
» The 18-person company, which opened in 2007, conducted research showing
» ReGenica stimulated hair growth in animals. It started its Phase 1 human
» trial to show the therapy was safe; no dangerous side effects were
» experienced, Ziering said.
» Histogen was also hoping the trial would show ReGenica's effectiveness,
» which might give the company the buzz it needs to raise funding, build a
» manufacturing facility and then begin Phase 2 trials
, Naughton said.
» The Phase 1 trial involves 25 men ages 18 to 45 who have varying stages
» of male-pattern baldness.
» Each of the balding spots was mapped into quadrants. Each quadrant
» received an injection of either the drug or a placebo. Some of
» the quadrants were also treated with microdermabrasion or lasers as well as
» the drug, to test previous medical theory that a wound helps to stimulate
» stem cells in the skin to regenerate hair follicles.
At 12
» weeks, penny-size pieces of scalp were biopsied to observe the changes.
» Histogen staff even counted the follicles and hairs sprouting out of them.
» Once the trial is completed, an independent data-monitoring board will
» review the results after five months and make an assessment.
More than
» 50 million men in the United States alone suffer from hair loss, and about
» 35 million women are dealing with the problem, said Ziering, who has been
» treating patients for hair loss for 18 years.
» “There's a tremendous need for something that can help people with their
» hair loss because there are many ramifications on people's lives,” Ziering
» said.
» Histogen's product shows promise to do multiple things, including slowing
» the progressive nature of hair loss, increasing the thickness of the
» follicles and actually getting new follicles to grow, the physician said.
» Histogen also sees ReGenica as a means toward lifesaving therapies that
» trigger stem cells to generate new tissue in damaged heart muscle and new
» neurons in damaged spinal cords, Naughton said.
» “We wanted to go after a market where there is really an unmet need and a
» large patient population, which could help us generate the cash flow to
» fund longer-term projects that would be more of a regulatory and
» reimbursement hurdle,” she said.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

17.02.2009, 19:37

@ Spanish Dude

My analysis: 6.5% increased numbers, 5.5% rejuvenated vellus

Ok, I have analyzed the high res. photos, and thanks to the animated gif, I have been able to compare both photos.
There are gained hairs, lost hairs, improved and worstened hairs.

In a small area, I have counted all these, and the results are:

unch= 92
new=10
lost=4
net increase= 6 (=6.5%)

Thickened hairs (from vellus to terminal and viceversa):
improv= 11
worse= 6
net improv= 5

As you see, hair number has increased 6.5%, and only 5.4% of hairs have been rejuvenated.

so, we can say that total improvement is 12%.

These results are very poor. Also, if this treatment is applied in a totally bald scalp, I think results will be even worse.

Maybe minoxidil can do better.

» good job!!
» I have not used any software to assist me, but I agree with you: I think
» haircount has not been increased significantly. In some spots, you see
» increased numbers, but in others, decreased numbers. It is quite weird, and
» makes little sense to me.
»
» Also, its a fact that hairs are longer in the "after" photo, and this
» fools us into thinking there is more density.
»
» I think this is a manipulation. why? very simple. If there was really
» increased hair numbers, and the company was really willing to show proof,
» they would have posted a clear photo proof. These photos oviously prove
» NOTHING, and there is no true efort to prove that there is any improvement.
»
»
» I hope I am wrong.
»
»
» » » Photos should be marked with reference points in order to compare
» both
» » » photos properly, and of course hair should be trimmed at the same
» » » hairlength.
» »
» » Hair counts:
» »
» » Baseline strong hairs: 388
» » Baseline weak hairs: 211
» »
» » 12-week strong hairs: 394
» » 12-week weak hairs: 208
» »
» » Method: I took the high-res images, marked each "strong" hair with a
» dot,
» » exported to a dot counting image analysis application and calculated
» the
» » dot count. Then I did the same for "weak" hairs. The definition of what
» » constitutes a "weak" or "strong" hair is my own (arbitrary) opinion.
» » Admittedly, the level of pigmentation/thickness required of a "strong"
» hair
» » was pretty high.
» »
» » Surprisingly, there isn't much difference in the hair counts (well
» within
» » the margin of error). During my quick analysis it became very obvious
» that
» » the average strand of hair is much thicker in the 12-week picture,
» though.
» »
» »
» » My conclusion is that it appears to have made strong hairs even
» stronger,
» » and weak hairs less weak, albeit not strong enough to be "really
» strong"
» » yet. With a slightly more lax threshold for "strong" hairs, the numbers
» » would probably be a little more favourable.
» »
» » I also agree that the hairs are generally longer, enhancing the
» impression
» » of higher hair density.
» »
» » It's a shame there doesn't seem to be a significant amount of
» completely
» » new hairs according to my count.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
Spanish Dude

17.02.2009, 15:51

@ p

I think this is, again, a manipulation.

good job!!
I have not used any software to assist me, but I agree with you: I think haircount has not been increased significantly. In some spots, you see increased numbers, but in others, decreased numbers. It is quite weird, and makes little sense to me.

Also, its a fact that hairs are longer in the "after" photo, and this fools us into thinking there is more density.

I think this is a manipulation. why? very simple. If there was really increased hair numbers, and the company was really willing to show proof, they would have posted a clear photo proof. These photos oviously prove NOTHING, and there is no true efort to prove that there is any improvement.

I hope I am wrong.


» » Photos should be marked with reference points in order to compare both
» » photos properly, and of course hair should be trimmed at the same
» » hairlength.
»
» Hair counts:
»
» Baseline strong hairs: 388
» Baseline weak hairs: 211
»
» 12-week strong hairs: 394
» 12-week weak hairs: 208
»
» Method: I took the high-res images, marked each "strong" hair with a dot,
» exported to a dot counting image analysis application and calculated the
» dot count. Then I did the same for "weak" hairs. The definition of what
» constitutes a "weak" or "strong" hair is my own (arbitrary) opinion.
» Admittedly, the level of pigmentation/thickness required of a "strong" hair
» was pretty high.
»
» Surprisingly, there isn't much difference in the hair counts (well within
» the margin of error). During my quick analysis it became very obvious that
» the average strand of hair is much thicker in the 12-week picture, though.
»
»
» My conclusion is that it appears to have made strong hairs even stronger,
» and weak hairs less weak, albeit not strong enough to be "really strong"
» yet. With a slightly more lax threshold for "strong" hairs, the numbers
» would probably be a little more favourable.
»
» I also agree that the hairs are generally longer, enhancing the impression
» of higher hair density.
»
» It's a shame there doesn't seem to be a significant amount of completely
» new hairs according to my count.




Spanish Dude is located in [NA] and he is available to meet: NO


Post reply
cal

17.02.2009, 11:05

@ TheOne

Why wait until 2015?

BTW:

It's easy to be angry at "Americans" but the average American off the street had no more control over any of the "American-caused" problems than anyone else on earth. These problem were the work of a tiny percentage of "America" with too much power and too little oversight. And most of these "American" firms & people hold half their assets overseas so they don't have to pay taxes anyway.

Many normal middle-class American citizens were very aware of the problems and saw this coming years before it all blew up. But in the last decade nobody with any power has been listening to this group at all. Even in America.




cal is located in [NA] and he is available to meet: NO


Post reply
TheOne

17.02.2009, 10:50

@ jonesing

Why wait until 2015?

http://www3.signonsandiego.com/stories/2009/feb/17/1b17hair213536-biotech-excited-about-hair-growth-r/

If your forehead is more like a fivehead, or you've started to see a lot more scalp at the crown of your head, the tiny San Diego biotechnology company Histogen has some promising news.
The company today is unveiling preliminary results from an early-stage clinical trial that showed its experimental hair regrowth therapy, ReGenica, increased new hair growth and the thickness of existing hair in men after 12 weeks.
“These results appear to be phenomenal, although this trial is still in the very early stages,” said Los Angeles-based hair transplant specialist Dr. Craig Ziering.
“Wimpy hairs became thicker, which is pretty significant to the patient because even if you cannot increase the numbers of hairs, if you increase the diameter, you increase the volume. And preliminary hair counts show there was an increase in new hair of 15 to 20 percent in some patients,” said Ziering, a paid member of the company's scientific advisory board.
ReGenica is made of a cocktail of proteins that are present in the early-stage embryo and help direct stem cells to become either hair, bone or blood, said Histogen Chief Executive Gail Naughton.
Although scientists have known about the role these proteins play, Histogen's aha moment was figuring out how to create them in a lab, said Naughton, who is also dean of San Diego State University's School of Business Administration.
Fibroblasts, early-stage stem cells that form connective tissue, are grown in the simulated low-oxygen and free-floating, low-gravity conditions of the embryo, Naughton said. The important Wnt proteins and growth factors then build up in that environment, she said.
The 18-person company, which opened in 2007, conducted research showing ReGenica stimulated hair growth in animals. It started its Phase 1 human trial to show the therapy was safe; no dangerous side effects were experienced, Ziering said.
Histogen was also hoping the trial would show ReGenica's effectiveness, which might give the company the buzz it needs to raise funding, build a manufacturing facility and then begin Phase 2 trials, Naughton said.
The Phase 1 trial involves 25 men ages 18 to 45 who have varying stages of male-pattern baldness.
Each of the balding spots was mapped into quadrants. Each quadrant received an injection of either the drug or a placebo. Some of the quadrants were also treated with microdermabrasion or lasers as well as the drug, to test previous medical theory that a wound helps to stimulate stem cells in the skin to regenerate hair follicles.
At 12 weeks, penny-size pieces of scalp were biopsied to observe the changes. Histogen staff even counted the follicles and hairs sprouting out of them. Once the trial is completed, an independent data-monitoring board will review the results after five months and make an assessment. More than 50 million men in the United States alone suffer from hair loss, and about 35 million women are dealing with the problem, said Ziering, who has been treating patients for hair loss for 18 years.
“There's a tremendous need for something that can help people with their hair loss because there are many ramifications on people's lives,” Ziering said.
Histogen's product shows promise to do multiple things, including slowing the progressive nature of hair loss, increasing the thickness of the follicles and actually getting new follicles to grow, the physician said.
Histogen also sees ReGenica as a means toward lifesaving therapies that trigger stem cells to generate new tissue in damaged heart muscle and new neurons in damaged spinal cords, Naughton said.
“We wanted to go after a market where there is really an unmet need and a large patient population, which could help us generate the cash flow to fund longer-term projects that would be more of a regulatory and reimbursement hurdle,” she said.




TheOne is located in [NA] and he is available to meet: NO


Post reply
jonesing

17.02.2009, 10:01

@ helpme007

Why wait until 2015?

just a thought- couldn't the apparent increase in individual hair thickness and possible increase in hair count that is being perceived as an increase in hair density due to the histogen treatment represent the normal course of hair growth that occurs over a 12 week period?




jonesing is located in [NA] and he is available to meet: NO


Post reply
helpme007

17.02.2009, 09:06

@ thegreek

Why wait until 2015?

» It looks very good regarding hair thickness.the analysis from P where he
» said "strong hair" in the before photo are definetely not "so strong" as
» the after photo.Hair thickness is very important in the overall look.The
» hair are definetely longer in the after photo but still they are much
» thicker!!!I think it looks very promising, at worst i see a much better
» minoxidil, realistically it looks to me as a new propecia(for people who
» have sides will be a gift from hairgod:) ).
»
» Still to early to get excited about it...lets live life until science like
» a good santa clauss will bring us the gift one day :)

well said :)



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