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fastfuse

28.01.2012, 11:22
 

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas (Hair Multiplication & Stem Cells Treatment)

http://www.prweb.com/releases/2012/1/prweb9129379.htm

Atlanta, GA (PRWEB) January 24, 2012

Aderans Research is attracting attention in the medical community once again; this time, the leader in cellular based hair regeneration made waves at the 2012 Winter Clinical Dermatology Conference in Maui.

Aderans Research Chief Executive Officer Ken Washenik, M.D., Ph.D., gave a presentation entitled “Emerging Therapies for Hair Loss.” He also participated in a conference faculty question and answer session with the audience, primarily comprised of practicing dermatologists.

His lecture centered on new and breakthrough treatments in the field of hair loss, including clinical ways of addressing the issue. Washenik addressed the progress Aderans Research is making with its Ji Gami™ family of cell products—a key part of the company’s cell-based solutions to androgenetic alopecia, or pattern hair loss.

“Our cell engineering process continues to be one of the most promising avenues on the horizon for treatment of androgenetic alopecia,” commented Vern Liebmann, Chief Operating Officer. “Our clinical trial is going strong, and we are working to conclude Phase 2 by next year, which will take us one step closer to finding a cure.”




fastfuse is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

28.01.2012, 12:12

@ fastfuse

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» ... we are working to conclude Phase 2 by next year,
» which will take us one step closer to finding a cure.”

In other words, they estimate that they are done with ALL phase 2 trails (all x "JiGami" versions) sometime in 2013. Then they will analyse all results, then - research goes on based on these phase 2 results, for maybe finding a cure one day (in 5 or 10 years or so) ...




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

28.01.2012, 13:00

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

»
» In other words, they estimate that they are done with ALL phase 2 trails
» (all x "JiGami" versions) sometime in 2013. Then they will analyse all
» results, then - research goes on based on these phase 2 results, for maybe
» finding a cure one day (in 5 or 10 years or so) ...

What's so surprising? This has all been known for a while. Their last protocols finish in 2013. They'll plan out their next steps depending upon what they get. The Phase 3 trials will start probably no earlier than 2014. And I believe you need two successful Phase 3 trials. It's not close at all. With that said, if all this works, 5 years away does seem possible. As always, key is whether it begins P3 trials.


Meanwhile posters get overexcited about Histogen and Replicel which are even more in an embryonic stage than Aderans....Give them 10 years...




KO is located in [NA] and he is available to meet: NO


Post reply
gettingthere

28.01.2012, 15:36

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» »
» » In other words, they estimate that they are done with ALL phase 2 trails
» » (all x "JiGami" versions) sometime in 2013. Then they will analyse all
» » results, then - research goes on based on these phase 2 results, for
» maybe
» » finding a cure one day (in 5 or 10 years or so) ...
»
» What's so surprising? This has all been known for a while. Their last
» protocols finish in 2013. They'll plan out their next steps depending upon
» what they get. The Phase 3 trials will start probably no earlier than 2014.
» And I believe you need two successful Phase 3 trials. It's not close at
» all. With that said, if all this works, 5 years away does seem possible. As
» always, key is whether it begins P3 trials.
»
»
» Meanwhile posters get overexcited about Histogen and Replicel which are
» even more in an embryonic stage than Aderans....Give them 10 years...

It doesn't make sense to be so negative. Aderans is doing MANY phase 2 trails to find out the best protocol so the phase 3 trail can go much quicker, also with a most drugs undergoing a phase 3 trail can be released to the market in a NDA (New Drug Application) and Aderans which uses your own cells and cultures them will be even easier to get to the market because they are using YOUR OWN cells. That's the plus with Replicel and Aderans is they aren't really releasing a drug, they are culturing your own cells and reinjecting them. Histogen can also speed through their trials because the regulations are more lax in Asia as far as I understand, if they show good results in this phase 2 trail, they can start a phase 3 trail and release it in Asia. Anyway, better to view the glass half full.




gettingthere is located in [NA] and he is available to meet: NO


Post reply
roger_that

MARYLAND,
28.01.2012, 15:47
(edited by roger_that, 28.01.2012, 16:06)

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Meanwhile posters get overexcited about Histogen and Replicel which are
» even more in an embryonic stage than Aderans....Give them 10 years...

KO, remember the difference between Replicel and Histogen on the one hand, and Aderans on the other.

Replicel and Histogen have a completely different BUSINESS STRATEGY than Aderans.

Replicel is running clinical trials in the Republic of Georgia, and Histogen is supposedly running trials in Singapore.

Aderans, while it might be a great company with brilliant people running it, are running their clinical trials conventionally, within the US.

Replicel and Histogen have a business strategy that is cut from a completely different cloth than Aderans', and it's different in two distinct ways:

1) First, launching clinical trials in low-regulation jurisdictions allows them to move faster, even to modify the trials "on the fly" without checking in with the FDA every time they want to change something. This SPEEDS UP THE TRIALS and SPEEDS UP THE COLLECTION OF VALUABLE DATA which allows them to learn and modify things as they proceed.

2) Secondly, once the trials are finished, the Replicel/Histogen strategy is NOT to try to launch their products in the USA first -- but instead, to launch it in as many countries as is feasible -- countries selected for the fact that they give some degree of credence to trials conducted in places like Georgia and Singapore.

In other words, these are Generation 2.0 biotech companies, concentrating not on the traditional, overregulated Western markets (like the USA), but instead, focusing from the jump on EMERGING MARKETS -- BOTH for their trials and for their initial commercial release and market "warm up" phase.

So, for instance, if Malaysia (sitting just north of Singapore) respects Singapore safety/efficacy trials (which they likely will), then Histogen will have captured the Malaysian market, a much bigger market than Singapore.

This might even allow Histogen to penetrate other Asian consumer markets like the Philippines, Taiwan, and China. None of these countries regulates pharmaceuticals and biotech products anywhere near as strictly as the US does. (My guess is that Japanese regulators will probably lock them out of Japan for a while, partially because their big competitor -- Aderans -- is a Japanese-based company.)

Similarly, when Replicel wraps up their clinical trials in Tiblisi, Georgia, they probably will choose to make a quick stab at the lucrative TURKISH market. Turkey sits right next-door to Georgia, and is a much bigger market, it's not part of the EU (so it doesn't share EU's mania for regulations), plus the Turkish economy is booming now and developing a big middle class.

From places like Turkey, Replicel could branch out all over the Middle East, and I have every confidence they will. They'll be all over the Persian Gulf, in Russia, and much of former Soviet Eastern Europe (the Baltics, Ukraine, etc.) before we can blink twice.

For these companies, overregulated traditional markets like the USA, Canada, and Western Europe are kind of "afterthoughts". Yes, they are important, and definitely part of the ultimate business plan, but they are SECONDARY.

Launching their products into emerging markets FIRST will do two things:

1) It will generate a lot of early cash flow... and

2) It will develop a global "buzz" and credibility for these products, which will inevitably generate intense pressure for them to be approved by Western regulatory agencies such as the FDA and the EU's equivalents.


If you can see the brilliance in that global business strategy being pursued by Replicel and Histogen, more power to you.

If you can't see that, I can't help you.

I think the troubles Aderans is obviously having has a lot to do with the FDA, and (behind-the-scenes), the US hair transplant docs getting involved to pressure the FDA to slow down the review and approval process.

This is quite easy for them to do, and I'm sure they're doing it.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.


Post reply
Iron_Man

28.01.2012, 16:05

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» »
» » In other words, they estimate that they are done with ALL phase 2 trails
» » (all x "JiGami" versions) sometime in 2013. Then they will analyse all
» » results, then - research goes on based on these phase 2 results, for
» maybe
» » finding a cure one day (in 5 or 10 years or so) ...
» ------------------
» What's so surprising? This has all been known for a while. Their last
» protocols finish in 2013. They'll plan out their next steps depending upon
» what they get. The Phase 3 trials will start probably no earlier than 2014.
» And I believe you need two successful Phase 3 trials. It's not close at
» all. With that said, if all this works, 5 years away does seem possible. As
» always, key is whether it begins P3 trials.

You should compare the new PR article with the following PR article (Sep 2011) …

http://www.hairsite.com/hair-loss/board_entry-id-93541.html#p93557

That still means all in all:

- They still couldn’t convince themselves;
- They still "will need knowledge from others" to find (maybe) a WORKING hair loss “cure” one day;

Anyways, how does that square with Dr. Ken Washenik’s “timeline” ??
[image]
Ah, I know – he said “if everything goes well” - or something … :-D




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

28.01.2012, 17:09

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

Ironman you are really reading too much into that article. It says literally nothing of substance, conferences are normal part of this field, and they're correct to state that bringing together people to exchange insights is good for the field.

The timeline he says is also pretty irrelevant, it's his best guess and he's not accountable to us to stick to it. Something people keep forgetting.


We have already known that the trials don't end till 2013, what exactly is surprising to you? Go on clinicaltrials.gov and see when their last trial ends.




KO is located in [NA] and he is available to meet: NO


Post reply
KO

28.01.2012, 17:12

@ gettingthere

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

»
» It doesn't make sense to be so negative. Aderans is doing MANY phase 2
» trails to find out the best protocol so the phase 3 trail can go much
» quicker, also with a most drugs undergoing a phase 3 trail can be released
» to the market in a NDA (New Drug Application) and Aderans which uses your
» own cells and cultures them will be even easier to get to the market
» because they are using YOUR OWN cells. That's the plus with Replicel and
» Aderans is they aren't really releasing a drug, they are culturing your own
» cells and reinjecting them. Histogen can also speed through their trials
» because the regulations are more lax in Asia as far as I understand, if
» they show good results in this phase 2 trail, they can start a phase 3
» trail and release it in Asia. Anyway, better to view the glass half full.


Phase 3 is the longest dude, and NDA is not used for something like this. This isn't a drug, it's a biologic and that has a different approval protocol. Injecting your own cells is fine, but once you culture them, it becomes a different story. It's not going to be as fast as you're saying.




KO is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

28.01.2012, 17:16

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Go on clinicaltrials.gov and see when their last trial
» ends.

Surely NOT in 2013 ...

http://clinicaltrials.gov/ct2/results?term=Aderans




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
FrankHair1

28.01.2012, 17:40

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » Go on clinicaltrials.gov and see when their last trial
» » ends.
»
» Surely NOT in 2013 ...
»
» http://clinicaltrials.gov/ct2/results?term=Aderans

Too bad Iron Man,

This one is february 2013 :

http://clinicaltrials.gov/ct2/show/NCT01451190?term=Aderans&rank=9

Estimated Primary Completion Date: February 2013 (Final data collection date for primary outcome measure) :-D

KO +1!!!!




FrankHair1 is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

28.01.2012, 18:16

@ FrankHair1

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » » Go on clinicaltrials.gov and see when their last trial
» » » ends.
» »
» » Surely NOT in 2013 ...
» »
» » http://clinicaltrials.gov/ct2/results?term=Aderans
»
» Too bad Iron Man,
»
» This one is february 2013 :
»
» http://clinicaltrials.gov/ct2/show/NCT01451190?term=Aderans&rank=9
»
» Estimated Primary Completion Date: February 2013 (Final data collection
» date for primary outcome measure) :-D

Yippie! The cure is near!




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

28.01.2012, 18:55

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

Moral of the story: updates and study results mean nothing to us. The one thing to watch out for, in fact the only thing is if they start P3 that shows both the treatment is expected to work, and that the firm is intent on bringing it to market.




KO is located in [NA] and he is available to meet: NO


Post reply
Freddie555

28.01.2012, 20:33

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Moral of the story: updates and study results mean nothing to us. The one
» thing to watch out for, in fact the only thing is if they start P3 that
» shows both the treatment is expected to work, and that the firm is intent
» on bringing it to market.

once its brought to market, i expect their phase II test facilities which they opened all through the US will stay open as they continue to evolve & improve their methods.

so i expect we will see incrementally better generations of cell therapy until we finally have a cure.

however the key is for them to put out something that is reasonably effective to replenish their coffers before it runs dry.

in the future, baldness will be like AIDS. if you catch it early and get on cell therapy treatment, you will be able to manage it and keep your hair or most of it for the rest of your life. unfortunately we may be the last generation to have to suffer through our younger years with this disease.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
KO

28.01.2012, 21:46

@ Freddie555

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

»
» however the key is for them to put out something that is reasonably
» effective to replenish their coffers before it runs dry.
»
» in the future, baldness will be like AIDS. if you catch it early and get
» on cell therapy treatment, you will be able to manage it and keep your hair
» or most of it for the rest of your life. unfortunately we may be the last
» generation to have to suffer through our younger years with this disease.

I believe that is exactly what Washenik thinks - the first few iterations will only be useful in thickening up hair transplants, with more comprehensive cures down the line.


In fact, the nature of cell based therapies is that it allows hair from *other* people to be implanted into your head because it is an immune privileged site. That way, if they can keep cell lines inductive for enough passages, we could have say Orlando Bloom's hair cells implanted into our balding heads.




KO is located in [NA] and he is available to meet: NO


Post reply
cal

29.01.2012, 13:00

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

Meanwhile there are still Histogen, Replicel, and Follica, which will all probably work much better if they don't totally fail IMHO.




cal is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

22.02.2012, 06:14

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Anyways, how does that square with Dr. Ken Washenik’s “timeline” ??
» [image]
» Ah, I know – he said “if everything goes well” - or something … :-D

It's still a pretty good question, because how does that ...

http://clinicaltrials.gov/ct2/show/NCT01451190?term=aderans&rank=9

... square with Dr. Ken Washenik’s initial/original “timeline” ??

Dr. Washenik was initially taking about "JiGami CN" -the expected "best working formula of the JiGami family" - right?
From the link ...
--------------
Official Title: A Multi-center, Phase 2 Study of Ji Gami(TM) CN That Evaluates the Efficacy and Safety of Injections of ex Vivo Expanded Cultured Occipital Autologous Dermal and Epidermal Cells Into the Hair Loss Area of the Scalp of Subjects

Estimated Enrollment: 40
Study Start Date: July 2011
Estimated Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
--------------

So according to Washenik's initial estimation, the JiGami CN phase II trail (CN=the best formula of ARI's JiGami family) should be completed anywhere mid 2012 - right?
Anyway, it seems we have to wait about 8 more month (if not more) for the final outcome -namely, until anywhere in spring, 2013 - at least for the phase II results.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

22.02.2012, 19:38

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

Where do you see that the CN version is the "best"?




KO is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

23.02.2012, 03:05

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Where do you see that the CN version is the "best"?

As said in my previous post, Dr. Washenik explains this...

http://www.aderansresearch.com/presentation/

[image]

He says in this video that they have “different versions of JiGami in their portfolio” (what is true) whereby they call the best working version in this portfolio of different versions “JiGami CN”. That’s at least what he said during an investor meeting in Tokyo in June, 2010 (simply watch the video).

Anyway, according to their here, in this thread, discussed (last) PR-article, I assume they didn’t see so far what they actually expected to see – not a complete failure, but truly NOT a cosmetic acceptable/useful result. Because for just "a few hairs here, and a few hairs there", such a costly "hair cells cloning procedure" in labs, it would/could be simply not worth/necessary to do this, because you already can buy "cloned hairs" in Europe, whereby for the latter you DEFINITELY will get them where you want them - and not where you just "hope" to see them grow.

Furthermore, the same WILL happen with Replicel’s 1-cell-type (dermal sheath cup cells) approach. They will probably announce a weird “success” or a “we are so excited” article in a few month (as ARI already did) just for their investors -and puss_ies, of course.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Iron_Man

23.02.2012, 03:32

@ fastfuse

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» http://www.prweb.com/releases/2012/1/prweb9129379.htm

» Vern Liebmann, Chief Operating Officer. “Our clinical trial is going strong,
» and we are working to conclude Phase 2 by next year, which will
» take us one step closer to finding a cure.”

By the way …
http://www.aderansresearch.com/ari_clinicupdates.html

[image]
It seems that trails in ALL “Radiant Research” facilities don’t even exist so far.
They just say “Future clinical study being planned”. I assume these studies (and recruitments) will NOT start, until they see something real “exciting” from the ongoing studies.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Freddie555

23.02.2012, 03:38

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

At least they are moving ahead and that can't be bad news.

I don't understand why they need so many sites.

Surely there's no shortage of bald guys in a 20 mile radius of any site.

The pack of wild, bald monkeys that infested the Astressin thread would more than cover the need for test subjects.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
Iron_Man

23.02.2012, 03:53

@ Freddie555

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» I don't understand why they need so many sites.

Oh I can tell you ...
[image]

ARI has been so far just a BIG money-grave ...
... and they still get too much.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
cal

23.02.2012, 16:45

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

because you already can buy "cloned hairs" in Europe, whereby for the latter you DEFINITELY will get them where you want them - and not where you just "hope" to see them grow.


We don't want to consistently get a few thousands hairs.

We want to get our entire heads restored in any way possible, whether it comes from a consistent procedure or not.

What part of this don't you understand?




cal is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

23.02.2012, 17:00

@ cal

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» What part of this don't you understand?

This part ...

» We want to get our entire heads restored in any way possible, whether it
» comes from a consistent procedure or not.

If this part would be so logical for you - what are you waiting for?




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

23.02.2012, 19:52

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» It seems that trails in ALL “Radiant Research” facilities don’t even
» exist so far.


I don't know about that. One of the test centers is right in front of my house, literally 5 mins away. They need a lot of centers because they're running like 15 trials.

I doubt a firm would pour this much money into a cause if there was a strong chance it was going to lose, anyways the future of Aderans basically rests on this treatment.




KO is located in [NA] and he is available to meet: NO


Post reply
KO

24.02.2012, 00:22

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Anyway, according to their here, in this thread, discussed (last)
» PR-article, I assume they didn’t see so far what they actually expected to
» see – not a complete failure, but truly NOT a cosmetic acceptable/useful
» result. Because for just "a few hairs here, and a few hairs there", such a
» costly "hair cells cloning procedure" in labs, it would/could be simply not
» worth/necessary to do this, because you already can buy "cloned hairs" in
» Europe, whereby for the latter you DEFINITELY will get them where you want
» them - and not where you just "hope" to see them grow.
»
» Furthermore, the same WILL happen with Replicel’s 1-cell-type (dermal
» sheath cup cells) approach. They will probably announce a weird “success”
» or a “we are so excited” article in a few month (as ARI already did) just
» for their investors -and puss_ies, of course.

Keep in mind though, the size of the hair shaft is directly proportional to the quantity of dermal papilla cells in the HF bulb. So if in practice the treatment grows some hairs, in theory, the results would be magnifiable by injecting a lot more cells.

One way it could be possible to do so is to put the follicles in telogen simultaneously, inject cells, and restart anagen....but we're getting ahead of ourselves here.




KO is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

24.02.2012, 01:53

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » It seems that trails in ALL “Radiant Research” facilities don’t
» even
» » exist so far.
»
» I don't know about that. One of the test centers is right in front of my
» house, literally 5 mins away. They need a lot of centers because they're
» running like 15 trials.

IF so ...
[image]
Source: http://www.facebook.com/photo.php?fbid=10150587264597448&set=pu.121586187447&type=1&theater
Or …
http://www.radiantresearch.com/trialdetails.asp?itemid=1921&profileid=32

What’s really interesting is that they actually started with recruiting 1.5 years ago (!) …

http://www.hairsite.com/hair-loss/board_entry-id-71553.html#p71943

… and their recruitment announcement is still online.

So why does ARI say on their website “Future clinical study being planned” for all Radiant Research facilities?

Didn't they find enough trail subjects/participants or what?




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

24.02.2012, 02:12

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Or …
» http://www.radiantresearch.com/trialdetails.asp?itemid=1921&profileid=32
»
» What’s really interesting is that they actually started with recruiting 1.5
» years ago (!) …
»
» http://www.hairsite.com/hair-loss/board_entry-id-71553.html#p71943
»
» … and their recruitment announcement is still online.
»
» So why does ARI say on their website “Future clinical study being
» planned” for all Radiant Research facilities?
»
» Didn't they find enough trail subjects/participants or what?

Well yeah, I think their trials started in about 2008, and they are still recruiting participants for the ones that are not finished (like the one that's being done at the center near my place). Since I take fin, I don't qualify in case you're wondering.

Two studies are still recruiting:
http://clinicaltrials.gov/ct2/results?term=aderans

This trial started in 2008:
http://clinicaltrials.gov/ct2/show/NCT01451021?term=aderans&rank=2




KO is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

24.02.2012, 02:26

@ KO

Aderans: "Our clinical trial is going strong ..."

» » So why does ARI say on their website “Future clinical study being
» » planned” for all Radiant Research facilities?
» »
» » Didn't they find enough trail subjects/participants or what?
»
» Well yeah, I think their trials started in about 2008, and they are still
» recruiting participants for the ones that are not finished (like the one
» that's being done at the center near my place).

Sure, ARI's phase II trails IN GENERAL started in 2008.

But why the hell is ARI saying on their website “Future clinical study being planned” for all Radiant Research facilities, when on the other hand Radiant Research still recruits (IF they really do)?

Radiant Research started to recruit anywhere mid 2010!




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
cal

24.02.2012, 02:49

@ Iron_Man

Aderans: "Our clinical trial is going strong ..."

These fluff press releases are great inkblot tests for people around here.

The releases don't really say anything. But they give everyone just enough material to read anything they want into it.




cal is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

24.02.2012, 03:15

@ cal

Aderans: "Our clinical trial is going strong ..."

» These fluff press releases are great inkblot tests for people around here.
»
»
» The releases don't really say anything. But they give everyone just enough
» material to read anything they want into it.

Ok …

» “Our cell engineering process continues to be one of the most promising
» avenues on the horizon for treatment of androgenetic alopecia,” commented
» Vern Liebmann, Chief Operating Officer. “Our clinical trial is going
» strong, and we are working to conclude Phase 2 by next year, which will
» take us one step closer to finding a cure.”

What part of this don't you understand?
Or which part of these comments do you find "fluff"?




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
rev

your nightmares,
24.02.2012, 05:01

@ Iron_Man

Aderans: "Our clinical trial is going strong ..."

» What part of this don't you understand?
» Or which part of these comments do you find "fluff"?

Your comments.

Now stop picking on Cal. He's sane; therefore, his comments hold more weight than yours.




rev is located in YOUR NIGHTMARES and he is available to meet: NO

---
Shittin on shills since 08.01.2008.


Post reply
FatalEvolution

UR'ANUS,
24.02.2012, 06:21

@ fastfuse

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Vern Liebmann, Chief Operating Officer. “Our clinical trial is going
» strong, and we are working to conclude Phase 2 by next year, which will
» take us one step closer to finding a cure.”

means sh*t to me. Man, ARI are in Phase 2 trials for like what ? 5 Years ?? They were already testing things in 2003, being in Phase 2 in 2007 and claiming to be ready to deliver in "end 2009" dixit Washenik.

We're in 2012 and the process is still dead stuck in Phase II. This news means pretty much nothing buddies !! Until Phase 3 isn't reached, ARI is just a pipe dream factory ....




FatalEvolution is located in UR\'ANUS and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.


Post reply
KO

24.02.2012, 08:52

@ Iron_Man

Aderans: "Our clinical trial is going strong ..."

» What part of this don't you understand?
» Or which part of these comments do you find "fluff"?

Dude just calm down until you get Replicel results, if they fail then we can come back to dissing ARI.




KO is located in [NA] and he is available to meet: NO


Post reply
Freddie555

25.02.2012, 04:51

@ FatalEvolution

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» We're in 2012 and the process is still dead stuck in Phase II. This news
» means pretty much nothing buddies !! Until Phase 3 isn't reached, ARI is
» just a pipe dream factory ....

on the flip side, they are not releasing some bullsh&t treatment that grows 2 hairs and rushing that to market.

i like their method of multiple Phase II trials simultaneously.

it gives the science the best shot at success.

raising the dead appears to be easier than growing hair.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
Iron_Man

25.02.2012, 05:18

@ Freddie555

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» i like their method of multiple Phase II trials simultaneously.
»
» it gives the science the best shot at success.

Does it mean Replicel will fail?




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Freddie555

26.02.2012, 05:15
(edited by Freddie555, 26.02.2012, 05:30)

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Does it mean Replicel will fail?

As they are doing trials with the FDA in mind and not pulling a Gho on us, I'm hopeful they will succeed in thickening existing hair at the very least.

disclaimer : I am a small time investor in Replicel.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
FatalEvolution

UR'ANUS,
28.02.2012, 11:14

@ Freddie555

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» on the flip side, they are not releasing some bullsh&t treatment that grows
» 2 hairs and rushing that to market.
»
» i like their method of multiple Phase II trials simultaneously.
»
» it gives the science the best shot at success.

To me, it means they are not confident with their product yet. They may well have a lot of money to inject into the R&D, things show that it's still in early stages.

ARI repeatedly made false claims during the last years.

In 2003 Washenik said the cure would be here in 5 years.

In 2007 Washenik said the cure would be here in end 2009.

In 2009 Washenik said the cure would be here in 5 years.

In 2012 Washenik said the cure could be here in late 2014 (or something like that).

He said the cure would be an "iterative process" e.g. the first versions will be less effective, just like your old mp3 player.

This company is in Phase II trials since 5 years.

The angle of approach have changed numerous time. From extracellular matrix, to buying Intercytex's technology, to finally come up with some hybrid-like procedure.

It does not sounds good to me.

It just sounds like a big company with some money trying to invest in R&D to find something, which is far from being found yet.




FatalEvolution is located in UR\'ANUS and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.


Post reply
hairman2

28.02.2012, 15:08

@ FatalEvolution

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» ARI repeatedly made false claims during the last years.
»
» In 2003 Washenik said the cure would be here in 5 years.
»
» In 2007 Washenik said the cure would be here in end 2009.
»
» In 2009 Washenik said the cure would be here in 5 years.
»
» In 2012 Washenik said the cure could be here in late 2014 (or something
» like that).
»
» He said the cure would be an "iterative process" e.g. the first versions
» will be less effective, just like your old mp3 player.
»
» This company is in Phase II trials since 5 years.
»
» The angle of approach have changed numerous time. From extracellular
» matrix, to buying Intercytex's technology, to finally come up with some
» hybrid-like procedure.
»
» It does not sounds good to me.
»
» It just sounds like a big company with some money trying to invest in R&D
» to find something, which is far from being found yet.

i agree it doesn't sound very promising when read like that... however.. the fact they haven't given up and are pursuing large scale clinical trails gives reason to hope that they are not betting on a dead horse.




hairman2 is located in [NA] and he is available to meet: NO


Post reply
KO

28.02.2012, 19:01

@ FatalEvolution

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » on the flip side, they are not releasing some bullsh&t treatment that
» grows
» » 2 hairs and rushing that to market.
» »
» » i like their method of multiple Phase II trials simultaneously.
» »
» » it gives the science the best shot at success.
»
» To me, it means they are not confident with their product yet. They may
» well have a lot of money to inject into the R&D, things show that it's
» still in early stages.
»
» ARI repeatedly made false claims during the last years.
»
» In 2003 Washenik said the cure would be here in 5 years.
»
» In 2007 Washenik said the cure would be here in end 2009.
»
» In 2009 Washenik said the cure would be here in 5 years.
»
» In 2012 Washenik said the cure could be here in late 2014 (or something
» like that).
»
» He said the cure would be an "iterative process" e.g. the first versions
» will be less effective, just like your old mp3 player.
»
» This company is in Phase II trials since 5 years.
»
» The angle of approach have changed numerous time. From extracellular
» matrix, to buying Intercytex's technology, to finally come up with some
» hybrid-like procedure.
»
» It does not sounds good to me.
»
» It just sounds like a big company with some money trying to invest in R&D
» to find something, which is far from being found yet.

That's because you read too much into his comments instead of focusing on what was going on behind. If anything, they've been very consistent with their approach, cultured epidermal and dermal cells, aka fibroblasts and keratinocytes for the past 10 years. And they've also been insistent starting with 10 years ago that first generation of HM will be useful primarily for thickening up hair transplants. What you need to grasp is that it takes a LONG time for these biotech firms to go from idea to drug, something like 10-15 years. ARI is no different, on the contrary this is pretty good as they're in actual clinical trials.

Don't believe me? Read this interview from TEN years ago:
http://www.hlhelp.com/hair_cloning/cloning_interview_washenik.cfm




The fact that you got excited at "cure is 5 years away" is YOUR problem, not Dr Washenik's.




KO is located in [NA] and he is available to meet: NO


Post reply
Freddie555

29.02.2012, 02:09

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

this industry and the medical industry in general is grossly inefficient.

if i worked at their pace on my job, i'd be booted out of the company within 6 months.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
Iron_Man

29.02.2012, 04:31

@ Freddie555

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» this industry and the medical industry in general is grossly inefficient.
»
» if i worked at their pace on my job, i'd be booted out of the company
» within 6 months.
[image]




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
FatalEvolution

UR'ANUS,
29.02.2012, 09:07

@ KO

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» The fact that you got excited at "cure is 5 years away" is YOUR problem,
» not Dr Washenik's.

It's the responsibility of the person who claims that the cure is 5 years away, that his speech will engage the credibility of his/her firm if that is not true.

I personally never got hyped with bold claims since we have never seen any photo nor articles detailing results in a scientific manner.

I just think it's a shame to say that HM is here in 5 years, every year for the last ten years, when it's far from being true. With time, i find it ridiculous, it's like an internet meme. But I've learned to know that this is all business mainly and fund raising.

cheers




FatalEvolution is located in UR\'ANUS and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.


Post reply
Iron_Man

29.02.2012, 09:21

@ FatalEvolution

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» I personally never got hyped with bold claims since we have never seen any
» photo nor articles detailing results in a scientific manner.
»
» I just think it's a shame to say that HM is here in 5 years, every year for
» the last ten years, when it's far from being true. With time, i find it
» ridiculous, it's like an internet meme. But I've learned to know that this
» is all business mainly and fund raising.
[image]




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
rev

your nightmares,
29.02.2012, 09:41

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » is all business mainly and fund raising.
» [image]

That's great; now do one with Muhammad.
And be sure to accredit yourself and jarjar as the illustrators .




rev is located in YOUR NIGHTMARES and he is available to meet: NO

---
Shittin on shills since 08.01.2008.


Post reply
Iron_Man

29.02.2012, 10:01

@ rev

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» That's great; now do one with Muhammad.
» And be sure to accredit yourself and jarjar as the illustrators .

Sorry, but I rather prefer YOU as the ideal illustrator ...
[image]




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
jarjarbinx

29.02.2012, 10:33

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » Where do you see that the CN version is the "best"?
»
» As said in my previous post, Dr. Washenik explains this...
»
» http://www.aderansresearch.com/presentation/
»
» [image]
»
» He says in this video that they have “different versions of JiGami in their
» portfolio” (what is true) whereby they call the best working version in
» this portfolio of different versions “JiGami CN”.
» That’s at least what he said during an investor meeting in Tokyo in June,
» 2010 (simply watch the video).
»
» Anyway, according to their here, in this thread, discussed (last)
» PR-article, I assume they didn’t see so far what they actually expected to
» see – not a complete failure, but truly NOT a cosmetic acceptable/useful
» result. Because for just "a few hairs here, and a few hairs there", such a
» costly "hair cells cloning procedure" in labs, it would/could be simply not
» worth/necessary to do this, because you already can buy "cloned hairs" in
» Europe, whereby for the latter you DEFINITELY will get them where you want
» them - and not where you just "hope" to see them grow.


Who says you can already buy cloned hairs in europe? Is it a fact that you can buy all the cloned hair you want in europe anytime you want to? I do not believe that.




jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

29.02.2012, 10:52
(edited by Iron_Man, 29.02.2012, 11:17)

@ jarjarbinx

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» Who says you can already buy cloned hairs in europe? Is it a fact that you
» can buy all the cloned hair you want in europe anytime you want to? I do
» not believe that.

http://www.fileden.com/files/2011/9/28/3202143/aaaa.jpg

All these hairs you can see on the completely slick bald area, are in fact cloned hairs. The counterparts of all these cloned hairs still exist as well on this patients' head.

Not just IN THEORY, you could even clone these already cloned hairs you can see on this photo AGAIN.

... WITHOUT the need of any specific "donor area".




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Iron_Man

29.02.2012, 11:57
(edited by Iron_Man, 29.02.2012, 12:24)

@ Iron_Man

What is a CLONE?

» » Who says you can already buy cloned hairs in europe? Is it a fact that
» you
» » can buy all the cloned hair you want in europe anytime you want to? I
» do
» » not believe that.
»
» http://www.fileden.com/files/2011/9/28/3202143/aaaa.jpg
»
» All these hairs you can see on the completely slick bald area, are
» in fact cloned hairs. The counterparts of all these cloned hairs still
» exist as well on this patients' head.
»
» Not just IN THEORY, you could even clone these already cloned hairs you can
» see on this photo AGAIN.
»
» ... WITHOUT the need of any specific "donor area".

What is a clone?
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
By Dr. Jerry Cooley
Source: img/uploaded_files/2879_file47.pdf

“Webster’s Dictionary defines a “clone” as one that appears to be a copy of an original form; duplicate is a synonym of clone. It is derived from the Greek word klōn, meaning twig. The word arose in the horticulture world, where the creation of a new plant from a twig of the original was called cloning. This is very similar to the hair autocloning technique, where auto (self) cloning (copying) occurs by plucking a “twig” of hair from the mother follicle to create daughter follicles. Cloning in scientific usage may also be applied to disparate laboratory techniques involving DNA, cells, or whole organisms. In scientific circles, it is not generally used to refer to somatic cell therapy. Implanting cultured dermal papilla to regenerate follicles is not “cloning”,as has been explained many times in the past.”
<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<

In simple words - the Aderans guys do NOT practice hair cloning!
They rather try to accomplish hair multiplication -whereby the latter (HM) has been defined by Dr. Gho in the 90s.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Ahab

29.02.2012, 14:49

@ rev

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » » is all business mainly and fund raising.
» » [image]
»
» That's great; now do one with Muhammad.
» And be sure to accredit yourself and jarjar as the illustrators .

ROFL!




Ahab is located in [NA] and he is available to meet: NO


Post reply
Ahab

29.02.2012, 14:50

@ Iron_Man

Aderans:“Our clinical trial is going strong, and we are working to conclude Phas

» » That's great; now do one with Muhammad.
» » And be sure to accredit yourself and jarjar as the illustrators .
»
» Sorry, but I rather prefer YOU as the ideal illustrator ...
» [image]

Laughing so hard my sides hurt!!!




Ahab is located in [NA] and he is available to meet: NO


Post reply
2020

29.02.2012, 15:08

@ Iron_Man

What is a CLONE?

IRON MAN STOP POSTING!! JUST GO AWAY!! PLZZ FOR THE LOVE OF GOD GO AWAY!!!!!!




2020 is located in [NA] and he is available to meet: NO


Post reply

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