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KO

06.03.2012, 19:08
 

Replicel is on Facebook! (Hair Multiplication & Stem Cells Treatment)

LOL


http://www.facebook.com/RepliCelLifeSciences?sk=wall




KO is located in [NA] and he is available to meet: NO


Post reply
2020

06.03.2012, 19:10

@ KO

Replicel is on Facebook!

» LOL
»
»
» http://www.facebook.com/RepliCelLifeSciences?sk=wall

what's so funny? It shows that they care. We should use this opportunity to ask them questions




2020 is located in [NA] and he is available to meet: NO


Post reply
KO

06.03.2012, 19:24

@ 2020

Replicel is on Facebook!

» » LOL
» »
» »
» » http://www.facebook.com/RepliCelLifeSciences?sk=wall
»
» what's so funny? It shows that they care. We should use this opportunity to
» ask them questions

I'm tempted to buy their stock. Except I have to declare my holdings to my company....not sure I want to do that yet lol.




KO is located in [NA] and he is available to meet: NO


Post reply
Ahab

07.03.2012, 00:45

@ KO

Replicel is on Facebook!

» LOL
»
»
» http://www.facebook.com/RepliCelLifeSciences?sk=wall

Likely a good sign.




Ahab is located in [NA] and he is available to meet: NO


Post reply
samt23

07.03.2012, 03:01

@ Ahab

Replicel is on Facebook!

» » LOL
» »
» »
» » http://www.facebook.com/RepliCelLifeSciences?sk=wall
»
» Likely a good sign.

I don't know what's funny about it.

You guys cry when they don't say anything ... Replicel tries to stay connected with their followers ... and you mock them ? Get real.




samt23 is located in [NA] and he is available to meet: NO


Post reply
Freddie555

07.03.2012, 03:53

@ samt23

Replicel is on Facebook!

3 weeks more to go and we will know if their method works.

i like that they are staying in touch with people. Sure beats begging companies for info and updates.




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001


Post reply
Iron_Man

07.03.2012, 04:41

@ 2020

Replicel is on Facebook!

» » http://www.facebook.com/RepliCelLifeSciences?sk=wall
»
» We should use this opportunity to
» ask them questions

Okay, ask them the following question:

Snippet from the facebook comments/answers...
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Replicel:
Hello, we contacted Dr. Kevin McElwee, RepliCel's Chief Scientific Officer, and he said that George Cotsarelis was looking at epithelial stem cells

- he did not look at mesenchymal stem cells in the hair follicles (ie. the stem cells that would provide the dermal papilla and dermal sheath cup).

So the epithelial stem cell component is normal, but the mesenchymal stem cell activity is unknown. You need both epithelial and mesenchymal cells to make a hair follicle. Damage/delete one or other of the populations and the hair follicle falls apart.

I hope this answers your question!

<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<

No, even more questions arise due to this answer …
[image]
Source: http://www.nature.com/jid/journal/v121/n6/fig_tab/5602058f4.html?url=/jid/journal/v121/n6/full/5602058a.html#figure-title

… because if “you need BOTH epithelial and mesenchymal cells to make a hair follicle” why the hell could they make hair follicles even in a mouse’ footpad WITHOUT epithelial hair follicle cells - but just with DP cells or DSC cells??

From Replicel’s research paper (2003) :
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
“The results indicate transplanted DP and DSC cells were equally capable of DP formation and hair follicle induction. This suggests the DP and peribulbar DSC may be functionally similar.”
<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<
Correct, MOUSE dermal papilla (DP) cells and MOUSE dermal sheath cup (DSC) cells work functionally similar. Meaning, this paper (and many other papers also) is the proof that BOTH, cells derived/isolated and multiplied from the Dermal Papilla (DP) as well as cells derived/isolated and multiplied from the Dermal Sheath Cup cells (DSC), are EQUALLY capable of hair follicle induction/creation. Cool, that means, as mentioned by the Replicel guys themselves, it seems that these two cell types work functionally similar. In other words, it seems (see pic above) that it doesn’t matter WHICH cell type of these two you use; the outcome is always the same - in MICE and or RATS. The pic above from their paper confirms this.

But there exactly is the problem also – because that also means that the outcome in HUMAN trails will be the same as e.g. Intercytex’s outcome – namely zero, zilch, nada in HUMANS.
Furthermore, if any of these two cell types and approaches would work so cool for HUMANS as for mice and rats, we already would have a cool hair loss cure product since a long time.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
hairman2

07.03.2012, 05:28

@ KO

Replicel is on Facebook!

» » » LOL
» » »
» » »
» » » http://www.facebook.com/RepliCelLifeSciences?sk=wall
» »
» » what's so funny? It shows that they care. We should use this opportunity
» to
» » ask them questions
»
» I'm tempted to buy their stock. Except I have to declare my holdings to my
» company....not sure I want to do that yet lol.

seriously?? maybe you should quit from your nazi employer?




hairman2 is located in [NA] and he is available to meet: NO


Post reply
hairman2

07.03.2012, 05:31

@ samt23

Replicel is on Facebook!

» » » LOL
» » »
» » »
» » » http://www.facebook.com/RepliCelLifeSciences?sk=wall
» »
» » Likely a good sign.
»
» I don't know what's funny about it.
»
» You guys cry when they don't say anything ... Replicel tries to stay
» connected with their followers ... and you mock them ? Get real.

I can see why it is funny.. it sort of lacks professionalism.. at least from a classical conservative view point.. but now a days even presidents and the likes use facebook..

but i agree i prefer this kind of "unprofessional" transparency over no transparency at all.




hairman2 is located in [NA] and he is available to meet: NO


Post reply
moawk

Germany,
07.03.2012, 08:44

@ Iron_Man

Replicel is on Facebook!

» » » http://www.facebook.com/RepliCelLifeSciences?sk=wall
» »
» » We should use this opportunity to
» » ask them questions
»
» Okay, ask them the following question:
»
» Snippet from the facebook comments/answers...
» >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
» Replicel:
» Hello, we contacted Dr. Kevin McElwee, RepliCel's Chief Scientific Officer,
» and he said that George Cotsarelis was looking at epithelial stem cells
»
» - he did not look at mesenchymal stem cells in the hair follicles (ie. the
» stem cells that would provide the dermal papilla and dermal sheath cup).
»
» So the epithelial stem cell component is normal, but the mesenchymal stem
» cell activity is unknown. You need both epithelial and mesenchymal cells
» to make a hair follicle. Damage/delete one or other of the populations
» and the hair follicle falls apart.
»
» I hope this answers your question!
» <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<
»
» No, even more questions arise due to this answer …
» [image]
» Source:
» http://www.nature.com/jid/journal/v121/n6/fig_tab/5602058f4.html?url=/jid/journal/v121/n6/full/5602058a.html#figure-title
»
» … because if “you need BOTH epithelial and mesenchymal cells to
» make a hair follicle” why the hell could they make hair follicles
» even in a mouse’ footpad WITHOUT epithelial hair follicle cells - but just
» with DP cells or DSC cells??
»
» From Replicel’s research paper (2003) :
» >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
» “The results indicate transplanted DP and DSC cells were equally capable
» of DP formation and hair follicle induction. This suggests the DP and
» peribulbar DSC may be functionally similar.”
» <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<
» Correct, MOUSE dermal papilla (DP) cells and MOUSE dermal sheath cup (DSC)
» cells work functionally similar. Meaning, this paper (and many other papers
» also) is the proof that BOTH, cells derived/isolated and multiplied from
» the Dermal Papilla (DP) as well as cells derived/isolated and multiplied
» from the Dermal Sheath Cup cells (DSC), are EQUALLY capable of hair
» follicle induction/creation. Cool, that means, as mentioned by the Replicel
» guys themselves, it seems that these two cell types work functionally
» similar. In other words, it seems (see pic above) that it doesn’t matter
» WHICH cell type of these two you use; the outcome is always the same - in
» MICE and or RATS. The pic above from their paper confirms this.
»
» But there exactly is the problem also – because that also means that the
» outcome in HUMAN trails will be the same as e.g. Intercytex’s outcome –
» namely zero, zilch, nada in HUMANS.
» Furthermore, if any of these two cell types and approaches would work so
» cool for HUMANS as for mice and rats, we already would have a cool hair
» loss cure product since a long time.

Apparently these replicel guys are just repeating what intercytex did and are not using THE MOST POWERFUL TOOL for HAIR GENERATION: Google.

They will most likely fail at generating new hair follicles but I'm pretty sure they are aware of your "google findings".

I suppose they are trying to attract investors for now so they must be pretty sure of having some moderate results in april...this is why they recruited early stage/moderate pattern balding dudes. They just plan to reverse miniaturization/strengthen existing follicles.

Chrome dome Bald hairy monkeys with hardcore shiny titanium-like bald plates like you are uncureable, this will most likely benefit early stage pattern baldness or diffuse thinners.

I'll probably won't benefit either but hopefully the young ones and those who are starting to bald do.




moawk is located in GERMANY and he is available to meet: NO

---
1. Predicted the failure of replicel, months in advance.
2. Predicted how their stock would rise/drop even with exact numbers.
3. Predicted the wild claims and crazyness that gc83uk's donor regeneration will cause among the HT industry during this summer. Including rassman's opinion, Dr. Woods special patients and Pro hair clinic photos.
4. Predicted Gho will open up a clinic in asia.
5. No prediction on Histogen. Looks promising if they didn't fake results.
6. Predicted the only viable HM technique other than Gho would surface when hairs are: "generated through the appropriate cell populations" -Team Tokyo 2012


[image]
- Moawk

Advice for patients: If you are considering a hair transplant, only consider Gho's HST and nothing else. First HT treatment in the world that offers: zero scarring, small downtime and donor regrowth.
http://www.hasci.com

Advice for Investors in HM: Invest in Team Tokyo.
http://www.tsuji-lab.com/en/research/organ/hair.html
Ditch replicel, aderans. They are done for and have no future.


Post reply
Iron_Man

07.03.2012, 09:03

@ moawk

Replicel is on Facebook!

» I suppose they are trying to attract investors for now so they must be
» pretty sure of having some moderate results in april...this is why they
» recruited early stage/moderate pattern balding dudes. They just plan to
» reverse miniaturization/strengthen existing follicles.

I’m pretty sure you found this information in a book at your school library – am I right?

Could you please post your book’s ISBN number? Thanks.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

07.03.2012, 09:44

@ Iron_Man

Replicel is on Facebook!

Ironman, I don't understand your post about epithelial v mesenchymal stem cells, could you clarify?


Interestingly enough, in Cotsarelis's experiment in 2007, they found that HF's were being generated by epithelial stem cells, not the HF stem cells in the bulge.




KO is located in [NA] and he is available to meet: NO


Post reply
neversaynever

07.03.2012, 14:11

@ moawk

Replicel is on Facebook!

Im new to all this, and will not pretend that im a scientist...but...

If Dr Gho can inject cells and grow HF's....isn't that proof enough that brand new HF's can be made? Granted its a method that isnt fully available yet (probably inconsistent results).

Maybe Im looking at it all too simply but...when i met gho, i asked him "if you can inject cells to grow to follicles, when dont you look into multiplying those cells?"

He answered "we are looking into that".

So is the only complication here the multiplication of cells? Its pretty damn hard to multiply cells to be used in the body safely, let alone fully functional. Then again, I just saw a woman on tv get a new cornea for her eyes using her stem cells!

Alot of hope on histogen and replicell on the forums, but I have a feeling replicel will bring something forward (more a treatment than a cure).

Naive post over.




neversaynever is located in [NA] and he is available to meet: NO


Post reply
moawk

Germany,
07.03.2012, 14:57

@ Iron_Man

Replicel is on Facebook!

» » I suppose they are trying to attract investors for now so they must be
» » pretty sure of having some moderate results in april...this is why they
» » recruited early stage/moderate pattern balding dudes. They just plan
» to
» » reverse miniaturization/strengthen existing follicles.
»
» I’m pretty sure you found this information in a book at your school library
» – am I right?
»
» Could you please post your book’s ISBN number? Thanks.

that has been hinted by hoffmann many times but it's good that you are interested in books. I suggest you start with any book and then move on to research papers you think you understand.

From your "hair loss expertise", you're so sure that replicel will show ABSOLUTELY NOTHING in April right?

How about this? if replicel shows "something" from their first trial...you disappear from these forums forever.

Up to the challenge?

Guessed so.




moawk is located in GERMANY and he is available to meet: NO

---
1. Predicted the failure of replicel, months in advance.
2. Predicted how their stock would rise/drop even with exact numbers.
3. Predicted the wild claims and crazyness that gc83uk's donor regeneration will cause among the HT industry during this summer. Including rassman's opinion, Dr. Woods special patients and Pro hair clinic photos.
4. Predicted Gho will open up a clinic in asia.
5. No prediction on Histogen. Looks promising if they didn't fake results.
6. Predicted the only viable HM technique other than Gho would surface when hairs are: "generated through the appropriate cell populations" -Team Tokyo 2012


[image]
- Moawk

Advice for patients: If you are considering a hair transplant, only consider Gho's HST and nothing else. First HT treatment in the world that offers: zero scarring, small downtime and donor regrowth.
http://www.hasci.com

Advice for Investors in HM: Invest in Team Tokyo.
http://www.tsuji-lab.com/en/research/organ/hair.html
Ditch replicel, aderans. They are done for and have no future.


Post reply
Iron_Man

07.03.2012, 16:11

@ moawk

Replicel is on Facebook!

» that has been hinted by hoffmann many times ...

Hoffmann? You mean the Replicel guy who has always been so extremely fascinated from the Intercytex guys and their "strategy"?

Should I quote him? :-D




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Iron_Man

07.03.2012, 16:34

@ KO

Replicel is on Facebook!

» Ironman, I don't understand your post about epithelial v mesenchymal stem
» cells, could you clarify?

Epithelium - is derived from the Greek word-combination "Epi" = "on/upon" + "Theli" = "tissue". In other words, the epithelium is tissue including (different) cells that lines/fills up surfaces of structures. Concerning hair follicles, with “epithelium” it is meant all the tissue(s)/tissue structures/layers including different cells between the hair shaft (aka dead and keratinized “hair”) and the connective tissue sheath, whereby with “connective tissue sheath” always the DERMAL SHEATH (DS) is meant. Or in other words, the dermal sheath (DS) or connective tissue sheath, surrounds the epithelium of the hair follicle (see the 2nd pic below).

Mesenchyme – is derived from the Greek/Latin word-combination “mes/meso/mesos” = “Mid/Middle” + “enkhuma/enchyma” = “Infusion”. In other words, it means when something is pushed or is molten or is formed into/within something during the EMBRYONIC development almost at the same time or mostly later while something (aka “fetus” and its skin) in general is in EMBRYONIC development. But I think pictures say more than thousand words …
[image]
The dermal sheath (DS) or “connective tissue sheath” including the dermal papilla (DP) contain mesenchymal cells and the tissue(s) between the hair shaft and the dermal sheath(DS)/CTS, which basically consists of the inner- and outer root sheath (everything what you can see in BLACK below), contains epithelial cells. In other words, just the cells within the dermal papilla (DP) and dermal sheath (DS) are specialized cells of mesenchymal origin.
[image]
Both tissues, mesenchymal- and epithelial tissue are separated by a basement membrane, whereby the latter or the combination of connective tissue sheath and basement membrane (aka “ExtraCellular Matrix - ECM”) acts as 1) barrier and 2) mediator – or also as a “filter/strainer”. Between epithelial- and mesenchymal tissue/cells, there are always molecular and mechanistic interactions during each hair cycle since its origins in a fetus (1st pic above) and until you die and whereby the dermal sheath (DS) or aka “connective tissue sheath” always acts a “barrier”/mediator between the “hair follicle” as a whole and the surrounding dermis(tissue).

In simple words, epithelial tissue including the epithelial cells originates from the EPIDERMIS (outermost layer of skin) and the dermal sheath (DS)/connective tissue sheath including the “mesenchymal cells” originates from the DERMIS (layer of skin below the epidermis) – therefore the names “DERMAL papilla” and “DERMAL sheath” and so on.

But there is another important thing:
As so many other things during an embryonic development, BOTH, mesenchymal- and epithelial tissue/cells have of course the same ORIGIN; mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibrils and unspecialized cells. That means, in a fetus, mesenchyme, or mesenchymal connective tissue, is a type of undifferentiated loose connective tissue that is mostly derived from mesoderm, although some are derived from other germ layers; e.g. some mesenchyme is derived from neural crest cells and thus originates from the ectoderm. In fact, most “embryologists” use the term mesenchyme only for those cells that develop from the mesoderm. Therefore, the term mesenchyme essentially refers to the morphology of embryonic cells. Epithelial cells do not show great migration activity within the tissue, whereas mesenchymal cells can migrate easily – and there exactly is THE PROBLEM; this can be an advantage (or is simply normal) but also a big disadvantage – it seems the latter especially for AGA patients, because these cells can easily migrate INTO a hair follicle, but also easily OUT OF a hair follicle if there is “a molecular-mechanistic leakage” which is unique (or rather being “normal”) for an AGA affected skin. That means, you can add mesenchymal cells (aka DSC cells etc) as much as you want, your tiny vellus hair follicles will act like a bottle without a bottom …
[image]
... and these "migrating-friendly" cells simply do not like their old friends anymore which migrate everywhere very close next to them.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Iron_Man

07.03.2012, 16:49

@ Iron_Man

Replicel is on Facebook!

By the way - maybe you guys understand Dr. Cooley's explanations a little bit better now ...
[image]
He explainted all this a little bit more specific later in a paper including the epithelial- vs. mesenchymal cells issue:
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
I understand why Dr. Cole is confused. In fact, I was quite confused for a long time about the plucked graft technique developed by Dr. Gary Hitzig. When I wrote in my 2006 Co-Editors’ Message that Dr. Hitzig was able to pluck intact follicles, I was wrong.

It only appeared that way to me using the stereomicroscope. The key to understanding this controversy is the dermal sheath. I have now plucked many thousands of hairs in the course of refining and developing this technique. I have examined them not only with the stereomicroscope but also histologically and microscopically with special stains (1% Dimethylaminocinnamaldehyde).

The following has become very clear:

The plucked hair follicle contains the inner and outer root sheath (epithelial cells) and sometimes the dermal papilla (mesenchymal origin) but never, in my experience, the dermal sheath. The dermal sheath is a practically invisible layer of mesenchmal cells that envelops the hair follicle, and in its lower section is thought to be a reservoir of mesenchymal stem cells that supplies the dermal papilla in much the same way that the “bulge” is the source of stem cells for matrix keratinocytes. The dermal sheath is always left behind after plucking. What is thought to occur is that, after a hair is plucked, the dermal sheath reconstitutes the dermal papilla and the bulge stem cells reconstitute all the epithelial layers of the follicle, thus allowing hair to regrow. Ever since humans developed self-awareness and opposable thumbs, they have likely been plucking hair from their bodies. Much to their consternation, the hair regrows. If I had a special plucking technique that completely removed the hair follicle, I would be redirecting much of my practice toward permanent hair removal, which would likely be very lucrative for me judging by the insatiable desire people have to get rid of unwanted hair.
Sadly, or fortunately, depending on how you look at it, this is not the case. Neither I, nor Dr. Hitzig, have ever seen permanent thinning in areas that were plucked. Since the dermal sheath and some epithelial stem cells are left behind after plucking, the hair follicle regenerates and hair regrows.

Trichotillomania is a biological model for repeated plucking so we can see what
happens over time. Many children have this common behaviour disorder and never develop permanent hair loss. It is only after years of repeated plucking that permanent alopecia develops, probably from depletion of epithelial stem cells. The autocloning
technique does not promise unlimited donor hair, but it does hold the possibility of a greatly expanded donor supply.
What interests me is that Dr. Cole says there is no evidence for hair duplication yet he doesn’t really explain the histologic data I presented. Looking at the rather coarse hair growing in isolation on a bald crown, and seeing the vertical histologic section of this hair with its apparent normal follicular architecture is indeed a piece of evidence.
<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
moawk

Germany,
07.03.2012, 17:17

@ Iron_Man

Replicel is on Facebook!

» » that has been hinted by hoffmann many times
» ...
»
» Hoffmann? You mean the Replicel guy who has always been so extremely
» fascinated from the Intercytex guys and their "strategy"?
»
» Should I quote him? :-D

Please keep doing it and call gho get 100 journal articles here BUT





take the challenge....

you scared aint ya :)




moawk is located in GERMANY and he is available to meet: NO

---
1. Predicted the failure of replicel, months in advance.
2. Predicted how their stock would rise/drop even with exact numbers.
3. Predicted the wild claims and crazyness that gc83uk's donor regeneration will cause among the HT industry during this summer. Including rassman's opinion, Dr. Woods special patients and Pro hair clinic photos.
4. Predicted Gho will open up a clinic in asia.
5. No prediction on Histogen. Looks promising if they didn't fake results.
6. Predicted the only viable HM technique other than Gho would surface when hairs are: "generated through the appropriate cell populations" -Team Tokyo 2012


[image]
- Moawk

Advice for patients: If you are considering a hair transplant, only consider Gho's HST and nothing else. First HT treatment in the world that offers: zero scarring, small downtime and donor regrowth.
http://www.hasci.com

Advice for Investors in HM: Invest in Team Tokyo.
http://www.tsuji-lab.com/en/research/organ/hair.html
Ditch replicel, aderans. They are done for and have no future.


Post reply
Iron_Man

07.03.2012, 18:00

@ moawk

Replicel is on Facebook!

» Please keep doing it and [re]call gho ...

Interesting you bring that up …

You guys remember what Dr. Gho explained in the Scissorboy video concerning WHERE exactly the (hair creating) hair stem cells are located in HUMAN hair follicles?

http://www.scissorboy.com/video/index/122/-1/all/40
[image]

… namely "NOT underneath the hair root as everyone thought“, aka NOT that much in the DSC region as described by the Replicel guys (below), nor in or near the DP.
[image]




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
ccmethinning

07.03.2012, 18:02

@ KO

Replicel is on Facebook!

» LOL
»
»
» http://www.facebook.com/RepliCelLifeSciences?sk=wall

I just think it is really funny that some guys on this forum think they know more than the guys at Replicel. You know, Drs Hoffmann and McElwee, two guys who are considered to be among the most brilliant and practiced in the hair biz. I highly doubt they overlooked something that a poster on these forums figured out.




ccmethinning is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

07.03.2012, 18:07

@ ccmethinning

Replicel is on Facebook!

» You know, Drs Hoffmann and McElwee,
» two guys who are considered to be among the most brilliant and practiced in
» the hair biz.

I would say rather BIZ than hair.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
moawk

Germany,
07.03.2012, 18:31

@ Iron_Man

Replicel is on Facebook!

» » You know, Drs Hoffmann and McElwee,
» » two guys who are considered to be among the most brilliant and practiced
» in
» » the hair biz.
»
» I would say rather BIZ than hair.

Come oooooooonnnn Iron Man :) , all the evidence points out replicel will fail :) ....take the challenge :) .

You ain't got nothing to lose.

I guess I'll have to make a thread on this soon, it will be fun :) .

Give yourself some time to think HOW to b1tch out of this one w/o lookin like a b1tch ;-)




moawk is located in GERMANY and he is available to meet: NO

---
1. Predicted the failure of replicel, months in advance.
2. Predicted how their stock would rise/drop even with exact numbers.
3. Predicted the wild claims and crazyness that gc83uk's donor regeneration will cause among the HT industry during this summer. Including rassman's opinion, Dr. Woods special patients and Pro hair clinic photos.
4. Predicted Gho will open up a clinic in asia.
5. No prediction on Histogen. Looks promising if they didn't fake results.
6. Predicted the only viable HM technique other than Gho would surface when hairs are: "generated through the appropriate cell populations" -Team Tokyo 2012


[image]
- Moawk

Advice for patients: If you are considering a hair transplant, only consider Gho's HST and nothing else. First HT treatment in the world that offers: zero scarring, small downtime and donor regrowth.
http://www.hasci.com

Advice for Investors in HM: Invest in Team Tokyo.
http://www.tsuji-lab.com/en/research/organ/hair.html
Ditch replicel, aderans. They are done for and have no future.


Post reply
2020

07.03.2012, 19:04

@ moawk

Replicel is on Facebook!

IRON MAN SHUT THE PUCK UP!!!!!! Replicel people know a lot more than you do.

for god sakes!! Dr.Gho has already joined Replicel and I heard they'll try fixing Vin Diesel...




2020 is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

07.03.2012, 19:27

@ 2020

Replicel is on Facebook!

» IRON MAN SHUT THE PUCK UP!!!!!! Replicel people know a lot more than you
» do.

hmmmm, but with such an answer, it doesn't look like they are serious or "brilliant" researchers, because it rather seems they don't understand their own science ...

Again - snippet from the facebook comments/answers...
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Replicel:
Hello, we contacted Dr. Kevin McElwee, RepliCel's Chief Scientific Officer, and he said that George Cotsarelis was looking at epithelial stem cells

- he did not look at mesenchymal stem cells in the hair follicles (ie. the stem cells that would provide the dermal papilla and dermal sheath cup).

So the epithelial stem cell component is normal, but the mesenchymal stem cell activity is unknown. You need both epithelial and mesenchymal cells to make a hair follicle. Damage/delete one or other of the populations and the hair follicle falls apart.

I hope this answers your question!
<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<

So HOW was it possible to form hairs even on a mouse' footpad without epithelial hair stem cells according to Replicel's answer? Because they say that they just injected mesenchymal cells and just with mesenchymal cells - no hair growth, according to them.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
2020

07.03.2012, 19:39

@ Iron_Man

Replicel is on Facebook!

ok... so you think Replicel is that stupid that it doesn't know their own research??

hm.... who is more trustworthy? Some guy from Iowa who probably works at subway or a team of doctors at Replicel?

Dr.Gho and Replicel will be fixing Vin Diesel in no time




2020 is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

07.03.2012, 19:43

@ 2020

Replicel is on Facebook!

» hm.... who is more trustworthy?

hm... always the guy who has nothing to lose?




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

07.03.2012, 19:57

@ 2020

Replicel is on Facebook!

Ironman, I don't disagree with you, as I pointed out earlier, Jahoda wrote about this 10 years ago:
http://www.nature.com/jid/journal/v121/n6/full/5602054a.html


As you pointed out, DP cells will migrate out of the HF in balding skin. However, we don't really know that it is necessarily the case here. For all we know, the new DP cells could be andro-resistant. We literally have no clue how DP cells are going to react in balding skin under the influence of androgens, as we understand little about the MPB process.


Furthermore, ARI has worked on culturing BOTH epidermal and dermal cells, aka fibroblasts and keratinocytes from the donor area, and then reinjected them into balding skin. That could be a way around it as well.


Also, it's unlikely this will rejuvenate hair follicles, Washenik was pretty dismissive of the possibility.

Keep in mind, these mesenchymal cells are not stem cells, AFAIK stem cells don't localize in the HF bulb, they're in the bulge.




KO is located in [NA] and he is available to meet: NO


Post reply
ccmethinning

07.03.2012, 20:53

@ Iron_Man

Replicel is on Facebook!

» » You know, Drs Hoffmann and McElwee,
» » two guys who are considered to be among the most brilliant and practiced
» in
» » the hair biz.
»
» I would say rather BIZ than hair.

Why would you say that?

Why don't you make a fake facebook account and ask Replicel to address your concerns? It is obvious the Repliel page admin has the ear of Dr. McElwee, so maybe you will get an answer.




ccmethinning is located in [NA] and he is available to meet: NO


Post reply
kekeke

08.03.2012, 09:59

@ Iron_Man

Replicel is on Facebook!

» So HOW was it possible to form hairs even on a mouse' footpad without
» epithelial hair stem cells according to Replicel's answer? Because they say
» that they just injected mesenchymal cells and just with mesenchymal cells -
» no hair growth, according to them.

Lol, it's not like the only epithelial stem cells in skin only exist in hair follicles. Complete fail, and please stop copy pasting wikipedia...




kekeke is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

08.03.2012, 11:36

@ kekeke

Replicel is on Facebook!

» Lol, it's not like the only epithelial stem cells in skin only exist in
» hair follicles. Complete fail, ...

So what, in a bald head, even in a slick bald head, there are nowhere mesenchymal cells? Ah, I know, they are also there, but they're not motivated anymore to produce terminal hairs - right? But the mesenchymal cells on the back of your head are always motivated - right? So this sounds logical; add lots of motivated mesenchymal cells to the unmotivated mesenchymal cell - voilà - hair growth. LOL.

If there were no "mesenchymal cell renewal" ALWAYS in your skin, your whole skin would "fall apart" within 2 weeks - not just hair follicles. In other words, for guys like Cotsarelis, there has been no reason to look for "mesenchmal cells", because I (and surely not Wikipedia) explained that already: "...it means when something is pushed or is molten or is formed into/within something during the EMBRYONIC development almost at the same time or mostly later while something (aka “fetus” and its skin) in general is in EMBRYONIC development." - maybe in more simple words - it is like when you press your finger into a balloon; the "balloon skin" and its assembling is basically always the same -even when you deform it. Or it's like a cat or a snake in a bag/sac/sack; the cat or snake is the "hair follicle" and the bag/sac/sack are your uppermost skin layers "ingrown" into the deeper dermis. So the "mesenchymal-hair-root-bag/sack" component is ALWAYS in the skin and renewals itself about every 2 weeks or so.

So all the most essential parts for hair follicle procuction, is always there - even a slick bald head.

Replicel: "George Cotsarelis was looking at epithelial stem cells - he did not look at mesenchymal stem cells in the hair follicles (ie. the stem cells that would provide the dermal papilla and dermal sheath cup)."

Again, there has been NO REASON to look for them (actually not even for epithelial stem cells) - because they are ALWAYS there! Because without them, your whole skin would "fall apart" within 2 weeks!

» and please stop copy pasting wikipedia...

Sorry, but I really do not need "loser generated content" for explaining skin/hair follicle BASICS.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
KO

08.03.2012, 13:26

@ Iron_Man

Replicel is on Facebook!

Ironman and kekeke, you guys are mixing up, or at least one of you is mixing up "Stem cells" and "Fibroblasts" and "epidermal cells".


Stem cells exist in both hirsute and bald tissue, that's not the problem here. What they need is *epidermal* cells along with *fibroblasts*, according to what Washenik has been saying. Replicel is injecting in multiplied fibroblasts without epidermal cells. That's what Ironman is trying to say.




KO is located in [NA] and he is available to meet: NO


Post reply
ccmethinning

08.03.2012, 13:45

@ KO

Replicel is on Facebook!

I will admit, I don't understand hair biology very much. I was curious as to what Ironman's reservations on Replicel were. I didn't understand every question that Ironman and other doubters have, but tried to some it up.

I e-mailed Dr. McElwee:

Me:
An editorial in the Journal of Investigative Dermatology says that there is no way Replicel's procedure can work because DSC cells will inevitably migrate out of the follicle.

Link: http://www.nature.com/jid/journal/v121/n6/full/5602054a.html


This certainly is discouraging news and does not bode well the procedure being developed by Replicel having much (if any) sucess. Do you have any response to this troubling revelation?

Also, there has been discussion that Replicel's procedure does not invole epithelial stem cells, but rather, only mesenchymal stem cells, and epithelial stem cells are indeed necessary to induce hair growth.


Dr McElwee:

George Cotsarelis showed that AGA affected skin still has a full complement of epithelial stem cells. If so, then there is no need for us to add extra epithelial stem cells - we can use the resident cells.

As for Dr Jahoda's commentary - the simple answer is we disagree. The detailed answer is privileged information.



I probably did not do justice to the questions people have and didn't ask them properly. But first hand information from the man himself is interesting nonetheless.




ccmethinning is located in [NA] and he is available to meet: NO


Post reply
KO

08.03.2012, 13:54

@ ccmethinning

Replicel is on Facebook!

You didn't ask the right question. We already know that balding skin has stem cells, Cotsarelis released a paper last year, something that was discussed here quite often.


HF synthesis needs EPIDERMAL cells, not "epithelial stem cells". Two different things.




KO is located in [NA] and he is available to meet: NO


Post reply
2020

08.03.2012, 14:29

@ KO

Replicel is on Facebook!

STOP ARGUING!!

Replicel will release their results next month, so let's just wait!

If it's a success then I'm sure their first order of business would be to fix Vin Diesel with a help of Dr.Gho




2020 is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

08.03.2012, 15:11

@ ccmethinning

Replicel is on Facebook!

» Dr McElwee:
»
» [...]
» As for Dr Jahoda's commentary - the simple answer is we disagree.
» The detailed answer is privileged information.


:-|

Okay, if we don't have this "privileged information", then every further discussion/speculation is useless and everybody can believe whatever they want.
[image]




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
2020

08.03.2012, 15:22

@ Iron_Man

Replicel is on Facebook!

STOP ARGUING!!

Replicel will release their results next month, so let's just wait!

If it's a success then I'm sure their first order of business would be to fix Vin Diesel with a help of Dr.Gho




2020 is located in [NA] and he is available to meet: NO


Post reply
Ahab

08.03.2012, 18:11

@ Iron_Man

Not necessarily true.!

» Trichotillomania is a biological model for repeated plucking so we can see
» what
» happens over time. Many children have this common behaviour disorder and
» never develop permanent hair loss. It is only after years of repeated
» plucking that permanent alopecia develops, probably from depletion of
» epithelial stem cells.

GRRRRR!!

Not necessarily true.

If follicles are programmed to go through the hair cycle a limited number of times, then it is possible that plucking a hair uses up one growth cycle prematurely.

This would mean that the follicle would reach its last hair cycle as much as six years earlier with each plucking.

So that any hair loss from a pluck or two today in a child would not be immediately seen, not being evident for decades and decades to come (sooner in an adult, much sooner in a middle aged adult).

So if, again, a follicle has a fixed number of cycles, and plucking uses up a cycle, than plucking will result in earlier hair loss than otherwise.

Again: not necessarily immediate, but earler hair loss than otherwise.

With my experience of observing hair loss for fifty years, I have almost always been proven right. And I suspect I am right about follicles being genetically limited to a fixed number of hair cycles because it explains a lot: It explains "scarring" alopecia and senescent alopecia--and explains why I've observed transplanted hair losing its vigor earlier than the hair remaining in the donor sites the transplants were taken from.




Ahab is located in [NA] and he is available to meet: NO


Post reply
Ahab

08.03.2012, 18:15

@ 2020

Replicel is on Facebook!

» STOP ARGUING!!
»
» Replicel will release their results next month, so let's just wait!
»
» If it's a success then I'm sure their first order of business would be to
» fix Vin Diesel with a help of Dr.Gho

If their results are bad news, I find it very, very strange that Replicel would show up on facebook--especially right before their results are made public--So I suspect they believe they will have something exciting to tell us, and have joined facebook because they anticipate a flurry of excited questions. And because joining facebook is laying the foundation for a future marketing campaign.

And remember, I am almost always right.




Ahab is located in [NA] and he is available to meet: NO


Post reply
KO

08.03.2012, 18:42

@ Ahab

Replicel is on Facebook!

» » STOP ARGUING!!
» »
» » Replicel will release their results next month, so let's just wait!
» »
» » If it's a success then I'm sure their first order of business would be
» to
» » fix Vin Diesel with a help of Dr.Gho
»
» If their results are bad news, I find it very, very strange that Replicel
» would show up on facebook--especially right before their results are made
» public--So I suspect they believe they will have something exciting to tell
» us, and have joined facebook because they anticipate a flurry of excited
» questions. And because joining facebook is laying the foundation for a
» future marketing campaign.
»
» And remember, I am almost always right.

They do not know the results. It's a fricking double blind trial. They have as much idea as you or Ironman. It means NOTHING.




KO is located in [NA] and he is available to meet: NO


Post reply
Mr. Z

08.03.2012, 18:53

@ Iron_Man

Replicel is on Facebook!

»
» Okay, if we don't have this "privileged information", then every further
» discussion/speculation is useless and everybody can believe whatever they
» want.



He finally gets it...




Mr. Z is located in [NA] and he is available to meet: NO


Post reply
2020

08.03.2012, 19:18

@ Ahab

Not necessarily true.!

» and explains why I've observed transplanted hair losing its vigor earlier than the hair remaining in the donor sites the transplants were taken from.


lool?? explain that again to me could ya?




2020 is located in [NA] and he is available to meet: NO


Post reply
ccmethinning

08.03.2012, 19:19

@ KO

Replicel is on Facebook!

» They do not know the results. It's a fricking double blind trial. They have
» as much idea as you or Ironman. It means NOTHING.

Are we sure they don't know the results yet? I thought that the last trialers came in for their checkup and that they started analysing the data. I mean they are gonna release results in a month, its gonna take them a while to analyze and put info together.




ccmethinning is located in [NA] and he is available to meet: NO


Post reply
2020

08.03.2012, 19:32

@ ccmethinning

Replicel is on Facebook!

how come no one is excited about Vin Diesel? Dr.Gho and Replicel worked really hard to fix him and look at him now!




2020 is located in [NA] and he is available to meet: NO


Post reply
ccmethinning

08.03.2012, 20:14

@ 2020

Replicel is on Facebook!

» how come no one is excited about Vin Diesel? Dr.Gho and Replicel worked
» really hard to fix him and look at him now!

WTF are you talking about?




ccmethinning is located in [NA] and he is available to meet: NO


Post reply
2020

08.03.2012, 20:40

@ ccmethinning

Replicel is on Facebook!

» » how come no one is excited about Vin Diesel? Dr.Gho and Replicel worked
» » really hard to fix him and look at him now!
»
» WTF are you talking about?

nvm you had to see that article from HLT to which I can't link to on this forum....




2020 is located in [NA] and he is available to meet: NO


Post reply
Ahab

09.03.2012, 00:53

@ 2020

Not necessarily true.!

» » and explains why I've observed transplanted hair losing its vigor earlier
» than the hair remaining in the donor sites the transplants were taken
» from.
»
»
» lool?? explain that again to me could ya?

When I had my plug transplants the hair in the transplanted plugs would fall out from the shock of being transplanted.

Then when more plugs were placed between previously transplanted plugs in a subsequent session, the newly placed plugs would lose their hair from shock and often the previously transplanted plugs would also lose their hair again, which means two cycles lost or as much as 12 years lost.

Some of my plugs lost hair 3 to 4 times from transplant shock--that's as much as 24+ years of cycling lost, so some of my plugs are growing as if I'm around 90 years old instead of 65.

Otherwise you tell me why now nearly thirty three years since my last transplant, my transplanted plugs are growing fewer and thinner hairs, while the hair in the donor areas is still strong.

You tell me what explains that if follicles are not limited to a fixed number of cycles.

I've been through it all. And I've had decades to observe and think about hair loss.

And I am almost always right.

And LOL to you, too, bit ch.




Ahab is located in [NA] and he is available to meet: NO


Post reply
Ahab

09.03.2012, 01:02

@ KO

Replicel is on Facebook!

» » » STOP ARGUING!!
» » »
» » » Replicel will release their results next month, so let's just wait!
» » »
» » » If it's a success then I'm sure their first order of business would be
» » to
» » » fix Vin Diesel with a help of Dr.Gho
» »
» » If their results are bad news, I find it very, very strange that
» Replicel
» » would show up on facebook--especially right before their results are
» made
» » public--So I suspect they believe they will have something exciting to
» tell
» » us, and have joined facebook because they anticipate a flurry of excited
» » questions. And because joining facebook is laying the foundation for a
» » future marketing campaign.
» »
» » And remember, I am almost always right.
»
» They do not know the results. It's a fricking double blind trial. They have
» as much idea as you or Ironman. It means NOTHING.

Isn't it possible that some of the trialists have grown so much hair that it's obvious which ones have had the real treatment?

I tell you something is up--I doubt they would bother to get on Facebook if it weren't for some reason they are confident of exciting trial results.

If they were unsure or confident of terrible results in a few weeks, why would they bother with Facebook now?




Ahab is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

09.03.2012, 01:48

@ Ahab

Replicel is on Facebook!

» I tell you something is up--I doubt they would bother to get on Facebook if
» it weren't for some reason they are confident of exciting trial results.

For a guy in his 60s, you sound like a child who still believe in Santa Claus and the Easter Bunny.

» If they were unsure or confident of terrible results in a few weeks, why
» would they bother with Facebook now?

Due to investors - and especially due to their money. For a guy in his 60s, it seems you learned nothing from the history.

I think it's time to post/quote some "confident of exciting trial results" from the Intercytex BUSINESS GUYS -ops, I meant "brilliant Intercytex hair researchers", of course.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
Iron_Man

09.03.2012, 02:52

@ Iron_Man

Replicel is on Facebook!

» I think it's time to post/quote some "confident of exciting trial results"
» from the Intercytex BUSINESS GUYS -ops, I meant "brilliant Intercytex hair
» researchers", of course.

Here are some - in chronological order ...
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
2nd March 2001
http://www.intercytex.com/icx/news/releases/pr2001/2001-03-02/
Hair loss affects approximately forty percent of men and twenty percent of women aged fifty and over. In the US alone, an estimated 40 million men and 20 million women suffer from baldness and spend $1.5 billion annually on hair loss therapies. Addressing this market, Intercytex is pioneering novel methods for the transplant of dermal hair follicle cells. This technology could be used as a means of regenerating hair, overcoming the need to remove whole hairs from one part of the body and subsequent transplant to another. It also opens the potential for large numbers of hair-generating cells to be expanded in tissue culture and packaged as a one-step solution to hair-loss.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
6th May 2004
Based on emerging positive results from its Phase I study, Intercytex also announced it is planning to initiate Phase II US and UK multi-centre clinical trials of TrichoCyte later this year.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
6th October 2006
http://www.intercytex.com/icx/news/releases/2006/2006-10-06/
Intercytex awarded £1.85m grant from the DTI to automate production of innovative hair regeneration therapy
The grant will be used primarily to develop a dedicated robotic system to support the commercial-scale production of dermal papilla (DP) cells, the main cells involved in hair regeneration and the key component of ICX-TRC. ICX-TRC, a hair regeneration product which has recently entered Phase II clinical trials.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
25th September 2007
http://www.intercytex.com/icx/news/releases/2007/2007-09-25/
Hair regeneration – first 12 patients treated in Phase II trial of ICX-TRC
Post period-end highlights
Preliminary data from Phase II trial of ICX-TRC for hair regeneration shows increased hair counts and good safety profile
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
18th December 2007
http://www.intercytex.com/icx/news/releases/2007/2007-12-18/
In September this year we announced the first results from the current Phase II trial. In the sub-group of subjects (5 in total) whose scalp was pre-stimulated at the time of injection all subjects showed substantial and visible increased hair counts at 6 and/or 12 weeks (13-105%). We believe this increased hair production is attributable to the interaction between the injected DP cells and the stimulated resident hair producing cells.
A further 5 subjects have now been treated with ICX-TRC using the pre-stimulation technique with 2 more expected in January. By the end of March 2008 we expect to announce preliminary 12 week data on up to 16 subjects in total and preliminary 24 week data on up to 10 subjects.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
18th September 2008
http://www.intercytex.com/icx/news/releases/2008/2008-09-18/
Intercytex Group plc – Interim results for the six months ended 30 June 2008
ICX-TRC - hair regeneration
Data from the Phase II trial shows increase in hair count in 11 out of 14 (79%) evaluable subjects at 24 weeks
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
26th January 2009
http://www.intercytex.com/icx/news/releases/2009/2009-01-26a/
Intercytex implements restructuring actions to reduce cash burn
Completion of the Phase II trial of ICX-TRC for hair regeneration continues to be expected at the end of this quarter
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
26th March 2009
http://www.intercytex.com/icx/news/releases/2009/2009-03-26/
ICX-TRC, a hair regeneration product. Phase II trial completed
· Positive data from Phase II trial announced today - increase in hair count in the majority of evaluable subjects observed at 48 weeks.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
The big OOOPS...
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
October 16 2009
http://www.baldingblog.com/2009/10/16/did-intercytex-fail/
Did Intercytex Fail?
"What happened was that the positive results of clinical trials were not as efficient as the lab ones. In other words although promising and exciting, not quite good enough to justify applying for a therapeutic product for the public."
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

Anyway, so what can we learn from these "confident and exciting trial results" reports?

In this business, such reports will ALWAYS be “confident and exciting” – as long as OOOPS happens …

We also know, that Aderans bought OOOPS -and they are still in the "OOOPS phase" ... :lookaround: ... even with the usage of BOTH cell types, epithelial and mesenchymal ("inducer and responder cells" ), from the DHT resistent donor area.




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply
cal

09.03.2012, 03:09

@ Iron_Man

Replicel is on Facebook!

Just to make a quick comment - I have always thought Ahab's theory on a fixed number of hair cycles makes a lot of sense.

And the fact that his theory is still an open question in 2012 is typical of how little basic hair loss info is really known.




cal is located in [NA] and he is available to meet: NO


Post reply
Iron_Man

09.03.2012, 03:24

@ cal

Replicel is on Facebook!

» Just to make a quick comment - I have always thought Ahab's theory on a
» fixed number of hair cycles makes a lot of sense.
»
» And the fact that his theory is still an open question in 2012 is typical
» of how little basic hair loss info is really known.

This is the famous actor, singer and entertainer Johannes Heesters
[image]
[image]
He died in December 2011. Age: 108.
He died with a FULL HEAD OF HAIR (maybe just a little bit thinning on top/front) and he has always been a heavy smoker.

Seems his hairs had lots of cycles and I guess he still would have almost a full head of hair with age 216 …




Iron_Man is located in [NA] and he is available to meet: NO

---
I documented the world’s 1st day-by-day (HST) donor hair regeneration process …


Post reply

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