» I'm pretty skeptical of Replicel until they show us how they maintain
» trichogenicity of DSC cells in vitro. Also the fact that they're using
» "DSC" cells, which no one else seems to recognize as a distinct category is
» a big red flag.
I don't think the DSC thing in itself is a big red flag. I think Kevin McElwee is claiming to have discovered them himself, as an entity distinct from DP cells. That would explain the RepliCel folks being the only ones to use that term. Only they use it because -- so far -- only they know the truth!
It seems to me that all previous research (Jahoda, early Cooley, early Gho, BioAmide, ICX, Aderans, etc.) was lumping all cells at the bottom outer part of the follicle together and labeling them "Dermal Papilla" cells.
In this explanation, maybe they didn't realize that cells from that part of the follicle are really a very MIXED population... some with highly inductive properties and others with much less inductive properties.
Previous researchers were expanding these cells grossly and achieving a very mixed final culture with a "Bell Curve" distribution of trichogenicity that altogether didn't amount to anything spectacular.
It seems what Dr. McElwee did is subject the different regions of the bulb to much greater scrutiny, expanding cultures from various micro-regions of the bulb.
Maybe the region which offered by far the best results was what he calls the DSC... and after all, if he noticed that, then HE gets to name the region... Hence, he and RepliCel seem to be the only people using the name "Dermal Sheath Cup". That's because they discovered it and they've named it.
In essence maybe what we have here is the "creme de la creme", a population way at the right-side of the Bell Curve in trichogenicity.
And of course when expanded into an injectible culture, this would be much more powerful than the weak results from that "mixed" population of DP cells.
Don't know for sure, but this at least seems to be a reasonable explanation...
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