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Astressin-B (Hair Multiplication & Stem Cells Treatment)

posted by KO, 15.01.2012, 22:07

I'm not that impressed with a company that's experimenting with a plethora
of different chemical "cocktails" anyway.

I do not believe Follica has really intended to impress you.



Anybody can just throw a bunch of sh*t together in a bottle, Lithium and
growth factors and stuff and then swab it on people's heads. Just another
random mixture of crap... 2 out of 15 patients grew hair in one of their
experiments. That's 13 out of 15 who grew nothing. Capeesh? ;)


Again, reading helps. You really seem to struggle with the concept, or perhaps the comprehension part. You realize that was the "control" group right. That means those people received no pharmacological intervention. Either you failed to grasp that, or despite knowing, you're ignoring it on purpose.

I don't know what it is about Follica that causes so many people to be
spellbound with anticipation. (Actually I've come to the conclusion it's
some subliminal combination of the name, "Follica" -- which is so evocative
and enticing, and Daphne Zohar, who many probably find sexy.)

Follica is respected because they have the best group of research talent out of any of the HM outfits. More than Histogen, more than Replicel. Daphne Zohar is indeed sexy, but you are probably just intimidated by that, hence the derision.




To me they seem just like 21st century snakeoil salesmen, a bit more
sophisticated because they have some indeterminate input from Dr.
Cotsarelis, but at the end of the day, it's still just a fairly random
chemical cocktail, a shot in the dark.

And you know this because? It is no different from Replicel in fact, they still have not explained how they're going to get over the problem of maintaining trichogencity in vitro.



It's like they keep throwing stuff at the wall to see what sticks.

The chances of a "kitchen sink" chemical cocktail, even a very "educated"
one, growing substantial hair will always be small. Sure, there's an
outside chance, but it'll always be a small chance. The reason is that the
growth and cycling of the human hair follicle is far, far more complicated
than any of these companies can describe in a little abstract of one or two
experiments.

You really think they don't know that the cycling of the HF is complicated? Seriously? Millar, Cotsarelis, and Price have spent their whole lives researching this stuff. They know far more than you or anybody else on this forum. There is no need to be a "know it all". They are experts on this field who have published a range of literature. You seem to have something personal against them.


The interrelations, pathways and biochemical feedback loops between all of
these hormones, growth factors, receptors, enzymes, proteins, etc. is so
complicated that any one of these "cocktails" will likely only address 15
or 20% of the entire picture, MAX. What about the rest? While they're
activating one or two parts of the picture, what about all the other parts?
And the truth is that you pretty much have to have ALL of the parts of
the cycle activated in perfect order and perfect proportion, with perfect
outside conditions, for involuted vellus hairs to be regenerated into
cosmetically valuable terminal hairs in sufficient numbers to make a real
phenotypic difference. Leave out any part of the whole and you're likely
to be stuck pretty much at square 1, or very close to it.

Again, see above.


On the flip-side, you have the little problem that every time you add
another chemical to the mix, you increase the potential for negative (and
possibly quite dangerous) side effects. And that's compounded still
further by potential for drug interactions between the different parts of
the mix.

Again, see above.


Look, I don't want to sound like the eternal, bitter cynic or party pooper
here. You get me wrong on that -- I'm not cynical, and I think there's a
huge potential for a cure with live cell therapy (Replicel, Aderans) or
tissue engineering (Lauster and the rest)... also, follicle splitting and
stem cell manipulation as Gho is doing. In fact, judging by people's posts
and the amount of cynicism here (with people threatening suicide every few
weeks) I'm probably much more optimistic than many of the rest of the crew
here when it comes to the potential for a cell-based cure.

To date, there is no evidence that cell therapy works on humans.


But this "chemical cocktail" stuff is getting to be a tiresome farce. It
just bespeaks a bunch of desperate companies, particularly Follica, barking
up the wrong tree.


Again, you know this because of what? Your deep experience in HL research?


Please don't take my harsh comments personally, but you really need to stop venting against Follica for no reason.




KO is located in [NA] and he is available to meet: NO


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