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Androgen signalling prevents hair cell differentiation (Hair Multiplication & Stem Cells Treatment)

posted by jarjarbinx, 06.02.2012, 12:27

Cotserellis is right. The reason we go bald is because androgens result
in
inhibition of stem cell differentiation into progenitor cells.
Specifically, Wnt is being inhibited which is important in signalling
cells
to make that transition.

I like Replicel's approach of bypassing the entire problem by replacing
the
existing DP cells with those from the back of the head which are
resistant
to this disruption. If indeed dermal sheath cup cells can migrate &
incorporate themselves into the surrounding hair follicles, they can
restart hair cycling. Certainly an excellent (preventative) treatment
for
those who are just beginning to lose their hair. Almost like a
vaccination. Perhaps every 5 years, the person would need a booster
shot
if these cells migrate away from the hair.


Not quite. Read Jahoda's response to McElwee's paper. What Jahoda basically
says is that there are changes in the physiology of balding skin that
prevent dermal papilla cells from integrating with extant hair follicles,
because in balding skin, the cells tend to move out of the HF. McElwee only
demonstrated it in rat footpads I believe. Furthermore it hasn't been
demonstrated that injected DP/DSC cells can induce follicle formation in
balding skin. They've done it on mice, done it on Amanda Reynolds'
arm, but balding skin is a different story. So I would not yet become very
optimistic. But we'll find out soon.


As for Cotsarelis, their main pathway is by mimicking Wnt by pushing
Lithium into wounded skin. One way the Follica patent suggested to get
around the androgen problem, and I believe this is what they'll pursue
eventually, is they're going to try to birth the neogenic hairs in
estrogen. Basically try to grow female-type hairs on the head. That way
they won't be androgen sensitive.


However just putting Wnt into your skin won't do it at all. That idea has
been discarded.





The idea has been "discarded" by who? By you? So what if you discarded the idea.

Histogen hasn't discarded the idea and after one year they produced a 73% increase in hair counts which increased coverage dramatically, PLUS they also increased the diameter to the already existing intermediate hairs which added to more coverage as well.




jarjarbinx is located in [NA] and he is available to meet: NO


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