Hair Loss - Androgen signalling prevents hair cell differentiation

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Androgen signalling prevents hair cell differentiation (Hair Loss Research & Clinical Trials)

posted by jarjarbinx, 06.02.2012, 12:27

» » Cotserellis is right. The reason we go bald is because androgens result
» in
» » inhibition of stem cell differentiation into progenitor cells.
» » Specifically, Wnt is being inhibited which is important in signalling
» cells
» » to make that transition.
» »
» » I like Replicel's approach of bypassing the entire problem by replacing
» the
» » existing DP cells with those from the back of the head which are
» resistant
» » to this disruption. If indeed dermal sheath cup cells can migrate &
» » incorporate themselves into the surrounding hair follicles, they can
» » restart hair cycling. Certainly an excellent (preventative) treatment
» for
» » those who are just beginning to lose their hair. Almost like a
» » vaccination. Perhaps every 5 years, the person would need a booster
» shot
» » if these cells migrate away from the hair.
» »
»
» Not quite. Read Jahoda's response to McElwee's paper. What Jahoda basically
» says is that there are changes in the physiology of balding skin that
» prevent dermal papilla cells from integrating with extant hair follicles,
» because in balding skin, the cells tend to move out of the HF. McElwee only
» demonstrated it in rat footpads I believe. Furthermore it hasn't been
» demonstrated that injected DP/DSC cells can induce follicle formation in
» balding skin. They've done it on mice, done it on Amanda Reynolds'
» arm, but balding skin is a different story. So I would not yet become very
» optimistic. But we'll find out soon.
»
»
» As for Cotsarelis, their main pathway is by mimicking Wnt by pushing
» Lithium into wounded skin. One way the Follica patent suggested to get
» around the androgen problem, and I believe this is what they'll pursue
» eventually, is they're going to try to birth the neogenic hairs in
» estrogen. Basically try to grow female-type hairs on the head. That way
» they won't be androgen sensitive.
»
»
» However just putting Wnt into your skin won't do it at all. That idea has
» been discarded.




The idea has been "discarded" by who? By you? So what if you discarded the idea.

Histogen hasn't discarded the idea and after one year they produced a 73% increase in hair counts which increased coverage dramatically, PLUS they also increased the diameter to the already existing intermediate hairs which added to more coverage as well.




jarjarbinx is located in [NA] and he is available to meet: NO

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