Deprecated: The each() function is deprecated. This message will be suppressed on further calls in /home/customer/www/hairsite.com/public_html/hair-loss/functions.php on line 155
Hair Loss Forum -

March 2017 - Trending Topics in our new forum

⇒ Stem cell hair restoration results - Dr. Cole vs Histogen vs RepliCel.
⇒ Dr. Paul Kemp, CEO of HairClone answers questions about follicle banking.
⇒ RepliCel year 2017 forecast for RCH-01 cell based hair regeneration.
⇒ Dr. Cole to start stem cell hair restoration trial in the US.
⇒ Dr. Umar's 6500 grafts life saving repair procedure for transplant victim.
⇒ FUE donor harvesting, what you must know when choosing a clinic.
⇒ Dr. Koray Erdogan raises the standard in FUE artistry skills.
⇒ Dr. Arvind on how to formulate your own toxic free shampoo.
 ⇒ Conference & FREE hair restoration consultations; cities worldwide.

This is a READ ONLY forum.
Access our brand new platform at HairSite New Forum to continue the discussion on these topics that you are interested in. All contents and discussions have been transferred to our new forum at  HairSite New Forum

Hair Loss Forum

HairSite Home   Forum Index   Personal Journal   Poll   Patient Statistics

 

Log in | User | Register

Search:  
Back to forum
Board view

BIG Question on Cromolyn Sodium not being addressed: Non-Mast Sources of PGD2 (Hair Multiplication & Stem Cells Treatment)

posted by roger_that, MARYLAND, 08.12.2012, 18:48
(edited by roger_that on 08.12.2012, 19:10)

First of all I want to say that I just went out and bought my first bottle of NasalCrom (Cromolyn Sodium) for use on my hair. I have been using NC for years, on and off, for my allergies. It completely eliminates my allergies, so I'm confident the stuff has some real potency at what it does -- which is stabilizing the Mast cells and preventing their degranulation. The spray bottle cost me, as usual, $16.99.

Now I want to call everyone's attention to a concern that occurred to me, which nobody seems to be addressing on this forum or -- especially -- on some of the other forums where lots of people are using and discussing Cromolyn Sodium.

I think this is a big point people have overlooked.

People are just assuming that Mast cells are the only major source of PGD2 in the scalps of people with MPB.

To me, there is no reason to make that assumption.

In fact, it is entirely possible that Mast cells are a relatively minor source of PGD2 in the scalps of people with MPB.

In that case, Cromolyn Sodium might not help that much at all.

I am still going to use it, to determine that, however.

People are assuming that everything is essentially the same with respect to "sources of PGD2" in the scalps of normal people as compared with balding people, and I think that's a hasty and uninformed assumption.

Remember that all PGD2 is created by the enzyme called PGD2 Sythase.

To my mind, PGD2 Synthase can theoretically be present and active in almost any cell, not just in Mast cells. (Parenthetically we know that another form of PGD2 Synthase exists in the brain and nervous system -- but that form is not relevant to this discussion.)

All it would take is for the PGD2 Synthase gene to become activated, for a cell to express PGD2 Synthase and start making a lot of PGD2.

We know that Mast cells exist in the skin of people with MPB and people without MPB.

Normally, the function of Mast cells is to produce and excrete chemicals called "cytokines", which include things like histamine, heparin, and PGD2, in response to allergens.

Therefore by inductive reasoning we can conclude that Mast cells have a lot of activated PGD2 Synthase genes and PGD2 Synthase enzyme, cranking out a relatively large amount of PGD2, in comparison with most other skin cells, which don't.

But where does that PGD2 Synthase enzyme come from? Probably in the Mast cells, their DNA expresses the PGD2 Synthase gene a lot -- significantly more than in the neighboring normal skin cells.

In people with MPB, we know that DHT interacts with the androgen receptors and that DHT/Receptor complex then affects the DNA inside the nucleus of skin cells, causing something to happen.

We now suspect that what happens is the creation of a lot of PGD2 Synthase in those cells. The PGD2 Synthase then goes on to create a lot of PGD2.

But there is absolutely no reason I can think of to assume that in people with MPB, that process is restricted to the Mast cells alone. That process could theoretically happen in ANY tissue cell. All you need is DHT exposure and the process would be kicked into effect.

So that means that if PGD2 Synthase is being expressed in non-Mast cells, and PGD2 is being created in those non-Mast cells, then a drug which "stabilizes the Mast cells" won't be able to take care of PGD2 being created in non-Mast cells.

If that is the case (and I don't know that it is, I just know that it is theoretically possible unless someone can explain to me why it actually doesn't happen in fact), then Cromolyn Sodium wouldn't really help us much, because it wouldn't have any effect on PGD2 being created outside of the Mast cells, in MPB affected people.

Does anyone get what I'm trying to say here?

I really hope I am wrong about this. This is just a suspicion, I very well may be wrong, and so I am going to try this experiment anyway.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

Post reply
 

Complete thread:

Back to forum
Board view
120100 Postings in 12546 Threads, 6081 registered users
Hair Loss Forum | Admin contact
| TERMS OF USE

 
This is a READ ONLY forum.
Access our brand new platform at HairSite New Forum to continue the discussion on these topics. All contents and discussions have been transferred to HairSite New Forum

Disclosure: This is an advertising site for our paid sponsors & advertisers. The contents, videos & photos on HairSite are provided by paid sponsors and are not endorsed by HairSite in any way. The recommendations, results, and representations made by our sponsors/advertisers do not reflect the opinions of HairSite. This site is to showcase successful hair restoration results only. It is not the mandate of this site to engage in the discussion of failed, unsuccessful procedures, lawsuits, litigations or complaint cases; comments of such nature, including external links, may be removed from the forum. Notify hairsite@aol.com any false, defamatory, misleading or inappropriate user generated contents for immediate removal from the forum. Also read Terms of Use & Privacy Statement |  HairSite advertisers: ASMED | Dr. Bhatti | Dr. Bisanga | Dr. Cole | Dr. Hakan Doganay | Dr.Epstein | Dr. Jones | Dr. Halder | Hasson & Wong | Dr. Klein | Dr. Madhu | Dr. Mwamba | Dr. Donald Ng| Dr. Poswal | Dr. Rahal | Dr. Razack | Dr. Reddy | Dr. Umar | Dr. Woods | DHI Global | HDC Clinic | |Lasercomb | Reviva Clinic | Ziering Medical|