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Inflamation/ PGD-2 and Mast Cell Degranulation? (Hair Loss Supplements)

posted by marku, 09.12.2012, 10:56

Have you seen this? GangsterBoy posted it over at HLH


PGD2 in hair folicles is not caused by HPGDS - hematopoietic prostaglandin D synthase BUT, by LPGDS lipocalin pgds.

Source? read the 22 march study of DR. cots. LPGds levels are highly elevated....

http://www.ncbi.nlm.nih.gov/pm...bin/nihms366359f2.jpg


Increased PGD2 pathway activity in balding scalp of men with AGA. (A) Expression of lipocalin-type PTGDS mRNA in bald versus haired scalp, as tested by qPCR. Data are means ± SEM (n = 4). (B and C) The amount of PTGDS protein in paired bald (B) and haired (H) scalps (n = 4), as shown by Western blotting with Ponceau stain used for verification of equal loading (B) and its quantitation as normalized to haired scalp (C). Data are means ± SEM. (D) PGD2 production in bald scalp, as tested by ELISA. Data are means ± SEM (n = 3). (E and F) Fold change in PGD2 (n = 17), 15-dPGJ2) (n = 7), and PGE2 (n = 17) expression in bald scalp compared to haired scalp (E). Total prostaglandin content is quantified in (F). Data are means ± SEM. *P < 0.05; **P < 0.01. In (F), P value compares haired versus bald samples for each prostaglandin.

knowing this, explain why cetrizine and other mastcell stabelizers, will NOT help against the elevated PGD2 in hairflocles.. so your basically missing the boat with hpgds stabilizers.





marku is located in [NA] and he is available to meet: NO


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