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CG 210 hair loss lotion (Topicals & Shampoos)

posted by Habemus, Portugal, 27.09.2013, 15:13

1ª Part

CG210 Enables Finasteride 1mg Users to Further Improve Hair Pattern: A
Randomized, Double-Blind, Placebo-Controlled Pilot Study
Akira Takeda1,2, Akio Sato2,3, Lei Zhang4, Saad Harti4, Geert Cauwenbergh4 and JiaWei Liu4,5*
1Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan
2Department of Regenerative Medicine Plastic and Reconstructive Surgery, Kitasato University School of
Medicine, Sagamihara, Kanagawa 252-0374, Japan
3Tokyo Memorial Clinic, Tokyo 151-0053, Japan
4Legacy Healthcare, Route de la Corniche 9B, 1066 Epalinges, Switzerland
5Teaching staff, PPCR course, Harvard Medical School, USA
Abstract
Background: The efficacy of Finasteride 1mg, the first-line treatment for male Androgenetic Alopecia (AGA), tends
to reach a plateau after several years’ treatment. Up to date, effective and safe options are limited because current
modalities managing AGA have so far not taken into account the two key issues particularly relevant to excessive hair
loss: the early onset of catagen (due to premature hair follicular cell apoptosis) and the frequently observed sustained
micro-inflammation in the scalp.
Objective: We investigated the potential synergic effect of combining the oral finasteride 1mg, acting on conversion
of testosterone to 5α-dihydrotestosterone, with CG210, a novel topical anti-hair loss product, acting on premature
apoptosis and micro-inflammation in the scalp.
Methods: We designed a 12-month, randomized, double-blind, placebo-controlled trial using CG210 in twenty
AGA volunteers already using Finasteride 1mg for at least three years. Hair diameters were assessed and compared
for hair pattern improvement.
Results: The increase of hair diameter in the “Finasteride 1 mg + topical CG210” group was 37.7% more than that
in “Finasteride 1 mg + topical placebo” group (p=0.002). No side effect was observed.
Conclusion: In addition to 5α-reductase inhibitors, our study puts forward the approach to simultaneously
address both premature cell apoptosis in the hair follicles and micro-inflammation in the scalp. The results suggest an
efficient mode in the management of AGA with improved efficacy over the currently referenced modality. Furthermore,
the studied topical CG210 may represent a new option for alopecia subjects, including those under finasteride 1mg,
to improve their hair pattern.
*Corresponding author: JiaWei Liu, Teaching staff, PPCR course, Harvard
Medical School, Legacy Healthcare, Route de la Corniche 9B, 1066
Epalinges, Switzerland, Tel: +41 78 8849782; Fax: +41 21 6534484; E-mail:
j.liu@legacyhealthcare.ch




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