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Inflamation/ PGD-2 and Mast Cell Degranulation? (Hair Loss Supplements)

posted by BioHairDude, 18.12.2013, 10:31

The distinction between H-PGD2 and L-PGD2 could be significant. AT-56 looks like the right formula to inhibit L-PGD2, with no antagonism toward PGE2 or H-PGD2:

http://www.jbc.org/content/284/12/7623.full

Since H-PGD2 is involved in sleep regulation, etc. and is very present in the brain, should a topical inhibitor be absorbed into the blood and cross the blood-brain barrier it might cause problems (unknown at this point I think, but worrisome). Also, taking oral preparations that significantly inhibit any PGD activity systemically, if taken in sufficient dosage to induce hair growth, the inflammation necessary for wound healing, etc. could be adversely affected. At this point, hoping for a topical solution that doesn't circulate too much in the rest of the body seems the best thing to hope for. Maybe At-56...?




BioHairDude is located in [NA] and he is available to meet: NO


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