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News on Follica (Hair Multiplication & Stem Cells Treatment)

posted by roger_that, MARYLAND, 14.05.2016, 13:30
(edited by roger_that on 14.05.2016, 13:58)

Cal, then my best assessment of why those hairs are still there is that your serum testosterone level is lower now than when you originally lost those hairs.

People don't realize it but serum testosterone levels have a LOT to do with the rate of hair loss, and whether and for how long hair loss progresses at all after a certain age. After age 30, serum testosterone decreases on average 1% per year in men.

Most likely, you lost the majority of hairs on your scalp (i.e., the ones you did lose) when your serum testosterone level was highest, and since then it's decreased. Even a modest decrease can push some people below the threshold necessary for further hair loss. A fraction above that level, and you'll continue to lose hair. A fraction below that level, and your hair loss stabilizes and you lose no more hair.

Remember, the serum testosterone level DIRECTLY influences how much DHT can be created by the alpha-reductase enzyme. The more testosterone you have in your blood, all other things being equal, the more T will be converted into DHT. It is inborn cellular DHT-sensitivity, genetically programmed, that results in the MPB phenotype.

Probably what happened with you is that you dermabraded your scalp and it was just enough to promote some "new" hair growth (actually not de novo, but revived miniaturized follicles). Meanwhile, your serum testosterone levels were dipping just below the threshold needed to cause terminal hairs to miniaturize, so those hairs you grew back were able to remain.

But the fact is, dermabrasion and tissue wounding are not, and never will be, a magic bullet to cure hair loss. If you want a complete explanation from me, the next time I have about 2 free hours, I'll write it up or try to explain here. Trust me. The very short answer is that "there are too many variables at play."

Wounding CAN promote some hair growth, but its effects are extremely anecdotal and case-specific, and it is NOT a sure thing. In fact it does the EXACT SAME THINGS as many other treatments which are under study right now and don't involve wounding at all (Histogen's HSC and others like that are just one example of a much more varied array of examples.)

So the question then becomes, why even use wounding at all? And when you look at the downsides -- tissue damage, follicle damage, etc. when done chronically -- combined with the fact that you actually have to do it chronically for it to be part of anything you could rationally call a "cure" or "reliable treatment" -- not to mention that tissue wounding alone is evidently far too weak of a stimulus to reliably regenerate terminal hair -- all these things and more add up to the fact that it is effectively a dead-end "technology".

Given that, when you assess the whole thing, wounding offers no "value added" to anything that's already on the table or in advanced stages of research right now. I feel confident that Follica -- even if they come out with something -- and they probably will, just for business purposes, to satisfy investors who have sunk millions into their work -- will never offer anything beyond what other companies will be able to do much better.

roger_that is located in MARYLAND and he is available to meet: YES
email to arrange a meeting.

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