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Kyocera Hair Multiplication Project (Hair Multiplication & Stem Cells Treatment)

posted by roger_that, MARYLAND, 23.07.2016, 23:01

Right. The issue had to do with culturing DP cells. Each cell generation is called a "passage" and with DP cells the problem is, the more passages you put them through (to multiply their numbers again and again) the weaker each successive passage of cells becomes when it comes to inducing new hairs to grow, or even helping to enlarge miniaturized follicles. So the more cells you try to get, the weaker they are... Leading to cells multiplied many times that have almost no inductive ability. Various researchers like Christiano and Jahoda tried to find novel ways to get around this problem, like using new and different culture techniques. They reported they had some success with that, but it looks like it was very limited.

Sanford-Burnham and other researchers (Shiseido?) more recently tried something completely different -- not using the body's native DP cells at all, but instead making new DP cells from stem cells. If new DP like cells could be made from stem cells in large numbers, this would circumvent the "passage" problem because the new DP like cells would be "fresh", like first generation, instead of like 10th generation or whatever. So they would have full hair-inductive powers.

The problem with that might be that you don't ONLY need DP cells, you also need "epithelial" cells at the top of the follicle to make a real, viable follicle that could theoretically cycle and function just like a natural one. So maybe Sanford-Burnham was concentrating on only one part of the problem. A functioning hair follicle is more than just a ball of DP cells.

That's where Organ Technologies and Kyocera come in -- they propose to actually build new follicle "seeds" (they call it a "primordium") which would have both the stem/epithelial cells, and the DP cells, embedded into a gel matrix to maintain their relative positions in the scalp. They claim this has already worked in mice, but I don't know how well, that's the question. And yes, I know these researchers say EVERYTHING works in mice. Remember Dr. Cotsarelis and PGD2 inhibition just a few years ago?

roger_that is located in MARYLAND and he is available to meet: YES
email to arrange a meeting.

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