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Complexity of the Hair Follicle (Hair Multiplication & Stem Cells Treatment)

posted by roger_that, MARYLAND, 12.08.2016, 21:29

Originally Posted by cal

. . . and whenever I point out that there is a method of making the body do the job itself, but we haven't even bothered to understand it (much less manipulate it) . . . you scoff at the idea.
You (and the majority of the HM research world) are looking for a practical MPB treatment where you prefer to find it. You aren't looking where the most promising evidence is pointing. It's that simple.

Well, I can at least understand why you would think that (wounding) would be a valid avenue of research that might lead to a cure or a great treatment... it's using the body's own resources and infrastructure to regenerate follicles, right?

My answer is that it's not that simple. It might seem that simple, but it's not. To regenerate follicles on a mass scale is really a problem of embryology. Hair follicle buds first develop from undifferentiate (or less-differentiated) tissue in the embryo, when two completely different parts of the embryo -- neural ectoderm and mesoderm (aka, "mesenchyme") come together at the epidermal-dermal junction. Hair follicles are, as far as I know, the ONLY bodily organ that develops from a fusion or juxtaposition of two entirely different levels of tissue in the embryo.

This happens in the midst of a very complicated embryonic chemical signaling environment, which is VASTLY different than that of the born infant or adult.

The key is the embryonic chemical signaling environment that tells the epidermal-dermal junctions to generate a hair follicle. Wounding tissue releases some growth factors that are similar to that environment, but I would say it may be only about 10% or 20% similar at the most. How do you make up the other 80 or 90%? I think you'll never make it up through leveraging tissue wounding. It's impossible. You won't get close.

That's why wounding's "results" are ALL anecdotal and meager. You never have anything like, substantial portions of bald people's scalps regrowing hair from a large superficial head wound (like someone's head being grazed by an axe or a sword). Maybe in the entire course of human history, wounds like this have happened hundreds of thousands of times, but where are the stories of bald people having all their hair restored? You just will not see this at all in the annals of medicine. what you will see is small numbers of hairs, or small patches of hair growing, at the most -- and even that, happening VERY rarely. That's because wounding does not replicate the embryologic chemical signalling environment... it only does so to a very minimal degree, and there is a hard limit on this that cannot be circumvented by more wounding. It's both a qualitative and a quantitative problem.

roger_that is located in MARYLAND and he is available to meet: YES
email to arrange a meeting.

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