Hair Loss Forum

Topical dutasteride (Topicals & Shampoos)

posted by Bryan, 17.12.2007, 05:48

» » So what about the NEW enzyme that starts to form after a day or so?
» »
»
» Byran, good question. How long would it take for the enzyme to reappear?

To get a reasonable idea of that, take a look at this often-posted graph from a medical journal study:

http://www.geocities.com/bryan50001/graph8.htm

It shows actual measured serum DHT levels for up to 7 days in human volunteers who took various SINGLE doses of finasteride. Even though finasteride is pretty much out of the body (or out of the blood, at least) a day or two after the last dose that you take, nevertheless it took up to a week or two for the blood levels of DHT of these test-subjects to get back to normal after those test doses. That's because the regeneration rate of the type 2 enzyme ITSELF is rather slow. Once finasteride or dutasteride knocks it out, it takes a while for new, "fresh" enzyme to be synthesized within the cell (finasteride and dutasteride are both considered to be irreversible inhibitors of the type 2 enzyme).

» The duta should stay in the follicle area for a while, i doubt it would
» all be systemically absorbed into the body that quickly, but just a guess.

Then I guess that would be the main point of contention here! I don't know of any evidence at all to suggest that dutasteride (or finasteride, for that matter) would hang around for such an incredible amount of time within the confines of a hair follicle, or just in the skin. I think it would last for a matter of MINUTES, not MONTHS!

.




Bryan is located in [NA] and he is available to meet: NO

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Complete thread:

• Topical dutasteride - rooster, 11.12.2007, 03:21
  • Topical dutasteride - trojanboy, 12.12.2007, 02:40
    • Topical dutasteride - rooster, 12.12.2007, 03:36
      • Topical dutasteride - brm, 13.12.2007, 00:06
  • Topical dutasteride - abcxyz, 13.12.2007, 01:06
  • Topical dutasteride - Bryan, 16.12.2007, 02:33
    • Topical dutasteride - rooster, 17.12.2007, 03:56
      • Topical dutasteride - rooster, 17.12.2007, 04:17
        • Topical dutasteride - Bryan, 17.12.2007, 06:00
      • Topical dutasteride - Bryan, 17.12.2007, 05:48
        • Topical dutasteride - Amilcar, 17.12.2007, 19:09
          • Topical dutasteride - Bryan, 17.12.2007, 20:36
            • Topical dutasteride - rooster, 17.12.2007, 20:43
              • Topical dutasteride - brm, 18.12.2007, 00:57
                • Topical dutasteride - rooster, 18.12.2007, 01:46
                  • Topical dutasteride - brm, 18.12.2007, 04:01
                    • Topical dutasteride - boris342002, 18.12.2007, 14:31
                    • Topical dutasteride - rooster, 18.12.2007, 16:27
                      • Topical dutasteride - rooster, 18.12.2007, 16:30
                        • Topical dutasteride - Bryan, 19.12.2007, 06:23
                          • Topical dutasteride - rooster, 14.01.2008, 03:06
                      • Topical dutasteride - brm, 18.12.2007, 17:48
                        • Topical dutasteride - rooster, 18.12.2007, 18:10
                          • Topical dutasteride - brm, 18.12.2007, 22:41
                            • Topical dutasteride - Bryan, 19.12.2007, 07:19
                          • Topical dutasteride - Bryan, 19.12.2007, 07:49
                        • Topical dutasteride - Bryan, 19.12.2007, 07:05
                    • Topical dutasteride - Bryan, 19.12.2007, 08:19
                      • Topical dutasteride - rooster, 19.12.2007, 22:59
                        • Topical dutasteride - The Rooster, 20.12.2007, 00:34
                        • Topical dutasteride - Bryan, 20.12.2007, 01:26
                  • Topical dutasteride - Bryan, 19.12.2007, 06:03
                • Topical dutasteride - Bryan, 19.12.2007, 05:45
              • Topical dutasteride - Bryan, 19.12.2007, 05:18
                • Topical dutasteride - rooster, 25.12.2007, 18:02
                  • Topical dutasteride - rooster, 27.12.2007, 03:10
                    • Topical dutasteride - HanginInThere, 12.01.2008, 03:51
                    • Topical dutasteride - boris342002, 18.01.2008, 02:38
                      • Topical dutasteride - keither, 05.06.2013, 08:03