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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 18.12.2007, 01:46

» I have the feeling that the basical principle of a chemical reaction
» escapes some of us here. I am no biologist but here's how I understand the
» problem. First of all, synthesization of DHT is probably constant
» throughout the day and throughout life though it follows some peak pattern
» as does any hormone production. The second point is that hormones abide to
» a general balance which is controlled by the pituitary gland through the
» feedback this gland receives in relation with the actual levels of the
» hormones involved. And the problem with DHT inhibitors is that they
» disrupt this natural balance (which with us, hairloss sufferers, creates a
» natural DHT upregulation and therefore a natural hairloss). This seems to
» explain why the effects both on libido and hairloss are unpredictable
» from an individual to another. Not to mention the problem of dosage. Last
» and most of all, we must not forget that once a molecule of fin or dut
» binds to a molecule of 5ar reductase, this fin or dut molecule is rendered
» USELESS to neutralize any other 5ar molecule. That's why this problem of
» "fin or dut hanging around" is probably pointless. The only problem is the
» supply rate of dht inibitors for them to be able to counter on a molecular
» basis (and according to the molecular coefficients the theoretical
» reaction involves) the relentless and natural production of this damned
» 5ar reductase. And the problem is, again, all the more difficult to tackle
» as the disruption of a chemical balance can have any kind of fallout. One
» of these possible consequences seems to be in many cases an accelerated
» rate of the production of 5ar reductase (since our system does not
» understand why the usual amount has suddenly dropped) or the creation of
» new androgenic receptors locally. Hence the apparent loss of efficiency of
» these drugs after some years. Many of us know better than me what i am
» trying to explain here but I think it deserved recalling.

Bryan posted an excerpt earlier that demostrates that even though finasterdide is out of the body completely the levels of DHT stays low for some time. This should mean that DHT is not synthasized rapidly, but over many days.




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