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Topical dutasteride (Topicals & Shampoos)

posted by brm, his room, 18.12.2007, 04:01

No. I believe we are confusing the LEVEL and the PRODUCTION RATE. If you pay attention to these graphs posted by Bryan, they show that the serum level is divided by 1.5, 2 or 3. This is a lot. Whereas the finasteride has become inactive after a few hours, maybe because of its quite short half life and above all because it has been chemically consumed to neutralize DHT molecules, the endocrine production of DHT (which I believe is at least as active as before the finasteride intake), is simply insufficient to get this level to its previous value within, say, a day or two. If your assumption was right, we should see a landing on the curve, which we do not see. What's more if you look closely at the curves, you can see how the average slope is way steeper for higher finasteride concentrations, which explains why all curves get near one to the other after 7 days. It means that the more DHT you inhibit, the more fresh dht is rapidly produced. If not, explain to me how the 5mg finasteride could be in the vicinity of the 0.2 or 0.04 mg after 7 days whereas the DHT was way more severely suppressed in the first place.




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