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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 18.12.2007, 16:27

» No. I believe we are confusing the LEVEL and the PRODUCTION RATE. If you
» pay attention to these graphs posted by Bryan, they show that the serum
» level is divided by 1.5, 2 or 3. This is a lot. Whereas the finasteride
» has become inactive after a few hours, maybe because of its quite short
» half life and above all because it has been chemically consumed to
» neutralize DHT molecules, the endocrine production of DHT (which I
» believe is at least as active as before the finasteride intake), is simply
» insufficient to get this level to its previous value within, say, a day or
» two. If your assumption was right, we should see a landing on the curve,
» which we do not see. What's more if you look closely at the curves, you
» can see how the average slope is way steeper for higher finasteride
» concentrations, which explains why all curves get near one to the other
» after 7 days. It means that the more DHT you inhibit, the more fresh
» dht is rapidly produced. If not, explain to me how the 5mg finasteride
» could be in the vicinity of the 0.2 or 0.04 mg after 7 days whereas the
» DHT was way more severely suppressed in the first place.

Scalp DHT suppression, which is felt to be correlated to a drug’s effectiveness, was measured and showed that finasteride decreased scalp DHT by 32%, dutasteride 0.5 mg by 51% and dutasteride 2.5 mg showed 79% suppression. DHT concentration in the blood was decreased 73% by finasteride, 92% by dutasteride 0.5mg. and 96% by dutasteride 2.5 mg . The speed by which drugs are eliminated from the body are measured by a value which is called “half-life”. The half-life of finasteride is six to eight hours whereas for dutasteride it is four to five weeks, which means that when one stops taking dutasteride, it will take several months before the drug is out of the system. When blood DHT was measured in these patients 12 weeks after stopping the medication, the finasteride treated patients had a normal DHT level while the dutasteride 0.5 still showed a 10% decrease and the dutasteride 2.5 mg treated patients still had significantly lowered DHT levels.




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