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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 18.12.2007, 16:30

As I suspected the enyzme resynthesis is very slow, justifying a once a week topical dutatasteride could be very effective. Also, I has some beleif that topical duta may be superior to oral.

in vitro binding studies examining the potential
of finasteride to inhibit either isozyme revealed a 100-fold
selectivity for the human Type II 5a-reductase over Type I isozyme
(IC50=500 and 4.2 nM for Type I and II, respectively). For both
isozymes, the inhibition by finasteride is accompanied by reduction of
the inhibitor to dihydrofinasteride and adduct formation with NADP+.
The turnover for the enzyme complex is slow ([half-life] approximately
30 days for the Type II enzyme complex and 14 days for the Type I
complex)."




rooster is located in [NA] and he is available to meet: NO


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