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Topical dutasteride (Topicals & Shampoos)

posted by brm, his room, 18.12.2007, 17:48

»
» Scalp DHT suppression, which is felt to be correlated to a drug’s
» effectiveness, was measured and showed that finasteride decreased scalp
» DHT by 32%, dutasteride 0.5 mg by 51% and dutasteride 2.5 mg showed 79%
» suppression. DHT concentration in the blood was decreased 73% by
» finasteride, 92% by dutasteride 0.5mg. and 96% by dutasteride 2.5 mg . The
» speed by which drugs are eliminated from the body are measured by a value
» which is called “half-life”. The half-life of finasteride is six to eight
» hours whereas for dutasteride it is four to five weeks, which means that
» when one stops taking dutasteride, it will take several months before the
» drug is out of the system. When blood DHT was measured in these patients
» 12 weeks after stopping the medication, the finasteride treated patients
» had a normal DHT level while the dutasteride 0.5 still showed a 10%
» decrease and the dutasteride 2.5 mg treated patients still had
» significantly lowered DHT levels.

Regarding dutasteride, we do not have the relevant charts. Maybe someone can post them, I don't know. You say that "The
speed by which drugs are eliminated from the body are measured by a value which is called “half-life”". I don't believe this is true. Halflife is a commonly used parameter in radioactivity to characterize the time needed for the activity of the product to be half what it is at t=0. The speed with which the drug is eliminated from the body would rather be the "excretion time". If Iremember correctly, dut's halflife is indeed around 5 weeks and dut's excretion time around 9 months. Well, never mind anyway since this does not answer our question. Nor does your post either. The harsh effect of dut just renders the "recovery time" even longer. Two more elements should be considered:1) we do not know whether dutasteride doesn't induce a phenomenon of hysteresis (a severe disruption of the basical recovery process) 2) Above all we have no indication as to the nature of this DHT blood serum measured in these indivduals (to say nothing about the evolution of their hairloss during these "recovery" months). That is, the recovery rate of DHT type 2 might be way higher than type 1's. That would explain why the overall DHT concentration remains low in dut's case. I really do believe this since I have more or less experienced it in my own case: having bloodtests carried out regurlarly, I managed to conclude that a high DHT blood serum level was far from being infallibly related to a severe hairloss in the 1 to 4 months following. The only explanation could be that the most harmful DHT type (2) was relatively lower than the type 1. But as to this last hypothesis, I may be completely wrong. I do not know whether DHT can be broken down into variable ratios of type 1 and type 2.
Finally, I would like to stress that we do in fact agree because whatever the situation following the intake of a single dose of DhT inhibitors, it takes some time for the dht level to reach its previous level. So it means anyway that hairloss HAS to remain relatively low in the wake. The point of contention is the reactivity of the endocrine production. You think it is weak. I think it is strong. But since the halflife of dut is way higher than fin's, your experiment is worth trying.:-) :-)




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