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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 18.12.2007, 18:10

The turnover for the enzyme complex is slow approximately
30 days for the Type II enzyme complex and 14 days for the Type I

The above is why i believe Duta topically once every 5 to 7 days could be very effective.

» »
» » Scalp DHT suppression, which is felt to be correlated to a drug’s
» » effectiveness, was measured and showed that finasteride decreased scalp
» » DHT by 32%, dutasteride 0.5 mg by 51% and dutasteride 2.5 mg showed 79%
» » suppression. DHT concentration in the blood was decreased 73% by
» » finasteride, 92% by dutasteride 0.5mg. and 96% by dutasteride 2.5 mg .
» The
» » speed by which drugs are eliminated from the body are measured by a
» value
» » which is called “half-life”. The half-life of finasteride is six to
» eight
» » hours whereas for dutasteride it is four to five weeks, which means
» that
» » when one stops taking dutasteride, it will take several months before
» the
» » drug is out of the system. When blood DHT was measured in these
» patients
» » 12 weeks after stopping the medication, the finasteride treated
» patients
» » had a normal DHT level while the dutasteride 0.5 still showed a 10%
» » decrease and the dutasteride 2.5 mg treated patients still had
» » significantly lowered DHT levels.
» Regarding dutasteride, we do not have the relevant charts. Maybe someone
» can post them, I don't know. You say that "The
» speed by which drugs are eliminated from the body are measured by a value
» which is called “half-life”". I don't believe this is true. Halflife is a
» commonly used parameter in radioactivity to characterize the time needed
» for the activity of the product to be half what it is at t=0. The speed
» with which the drug is eliminated from the body would rather be the
» "excretion time". If Iremember correctly, dut's halflife is indeed around
» 5 weeks and dut's excretion time around 9 months. Well, never mind anyway
» since this does not answer our question. Nor does your post either. The
» harsh effect of dut just renders the "recovery time" even longer. Two more
» elements should be considered:1) we do not know whether dutasteride doesn't
» induce a phenomenon of hysteresis (a severe disruption of the basical
» recovery process) 2) Above all we have no indication as to the nature of
» this DHT blood serum measured in these indivduals (to say nothing about
» the evolution of their hairloss during these "recovery" months). That is,
» the recovery rate of DHT type 2 might be way higher than type 1's. That
» would explain why the overall DHT concentration remains low in dut's case.
» I really do believe this since I have more or less experienced it in my own
» case: having bloodtests carried out regurlarly, I managed to conclude that
» a high DHT blood serum level was far from being infallibly related to a
» severe hairloss in the 1 to 4 months following. The only explanation could
» be that the most harmful DHT type (2) was relatively lower than the type
» 1. But as to this last hypothesis, I may be completely wrong. I do not
» know whether DHT can be broken down into variable ratios of type 1 and
» type 2.
» Finally, I would like to stress that we do in fact agree because whatever
» the situation following the intake of a single dose of DhT inhibitors, it
» takes some time for the dht level to reach its previous level. So it means
» anyway that hairloss HAS to remain relatively low in the wake. The point of
» contention is the reactivity of the endocrine production. You think it is
» weak. I think it is strong. But since the halflife of dut is way higher
» than fin's, your experiment is worth trying.:-) :-)

rooster is located in [NA] and he is available to meet: NO

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