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Topical dutasteride (Topicals & Shampoos)

posted by Bryan, 19.12.2007, 07:05

» Regarding dutasteride, we do not have the relevant charts. Maybe someone
» can post them, I don't know. You say that "The speed by which
» drugs are eliminated from the body are measured by a value which
» is called “half-life”". I don't believe this is true. Halflife is a
» commonly used parameter in radioactivity to characterize the time needed
» for the activity of the product to be half what it is at t=0. The speed
» with which the drug is eliminated from the body would rather be the
» "excretion time".

The rate at which drugs are eliminated from the body does indeed resemble the rate at which radioactivity decays, for the simple reason that each molecule of the drug is acted upon relatively independently. For example, if each molecule of a given drug floating around in the bloodstream has a 1/2 chance of being "caught", degraded, and excreted by the liver each time that molecule passes around the body, then the total number of those drug molecules in the blood at any given time will indeed drop at a rate that does generally resemble that of radioactive decay.

» Two more
» elements should be considered:1) we do not know whether dutasteride
» doesn't induce a phenomenon of hysteresis (a severe disruption of the
» basical recovery process)

I don't understand what you mean.

» 2) Above all we have no indication as to the nature of
» this DHT blood serum measured in these indivduals (to say nothing about
» the evolution of their hairloss during these "recovery" months). That is,
» the recovery rate of DHT type 2 might be way higher than type 1's. That
» would explain why the overall DHT concentration remains low in dut's case.
» I really do believe this since I have more or less experienced it in my own
» case: having bloodtests carried out regurlarly, I managed to conclude that
» a high DHT blood serum level was far from being infallibly related to a
» severe hairloss in the 1 to 4 months following. The only explanation could
» be that the most harmful DHT type (2) was relatively lower than the type
» 1. But as to this last hypothesis, I may be completely wrong. I do not
» know whether DHT can be broken down into variable ratios of type 1 and
» type 2.

I don't follow much of what you say in that paragraph, either, but I will say that in the Gisleskog et al studies on dutasteride and finasteride which I have quoted from widely on hairloss sites like this one, slightly over 80% of blood DHT was judged to have come from the type 2 enzyme, while the remainder (slightly less than 20%) was judged to have come from the type 1 enzyme.

» Finally, I would like to stress that we do in fact agree because whatever
» the situation following the intake of a single dose of DhT inhibitors, it
» takes some time for the dht level to reach its previous level. So it means
» anyway that hairloss HAS to remain relatively low in the wake. The point of
» contention is the reactivity of the endocrine production. You think it is
» weak. I think it is strong. But since the halflife of dut is way higher
» than fin's, your experiment is worth trying.:-) :-)

What do you mean by "reactivity of the endocrine production"? As I pointed out earlier, DHT production remains low as long as you take a 5a-reductase inhibitor. Testosterone synthesis goes up a little, but DHT stays low.


Bryan is located in [NA] and he is available to meet: NO

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