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Topical dutasteride (Topicals & Shampoos)

posted by Bryan, 19.12.2007, 08:19

» No. I believe we are confusing the LEVEL and the PRODUCTION RATE. If you
» pay attention to these graphs posted by Bryan, they show that the serum
» level is divided by 1.5, 2 or 3. This is a lot. Whereas the finasteride
» has become inactive after a few hours, maybe because of its quite short
» half life and above all because it has been chemically consumed to
» neutralize DHT molecules, the endocrine production of DHT (which I
» believe is at least as active as before the finasteride intake), is simply
» insufficient to get this level to its previous value within, say, a day or
» two.

How can the "endocrine production of DHT" be just as active as before finasteride intake, once finasteride knocks-out most of the 5a-reductase type 2?

» If your assumption was right, we should see a landing on the curve,
» which we do not see.

Can you explain what you mean by that a little better?

» What's more if you look closely at the curves, you
» can see how the average slope is way steeper for higher finasteride
» concentrations, which explains why all curves get near one to the
» other after 7 days.

I wouldn't say that it's "way steeper".

» It means that the more DHT you inhibit, the more fresh
» dht is rapidly produced.

Nah, I don't think so.

» If not, explain to me how the 5mg finasteride
» could be in the vicinity of the 0.2 or 0.04 mg after 7 days whereas
» the DHT was way more severely suppressed in the first place.

Because it only takes about 7 days to recover most (but not all) of the missing DHT.


Bryan is located in [NA] and he is available to meet: NO

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