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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 19.12.2007, 22:59

» » No. I believe we are confusing the LEVEL and the PRODUCTION RATE. If you
» » pay attention to these graphs posted by Bryan, they show that the
» serum
» » level is divided by 1.5, 2 or 3. This is a lot. Whereas the
» finasteride
» » has become inactive after a few hours, maybe because of its quite short
» » half life and above all because it has been chemically consumed to
» » neutralize DHT molecules, the endocrine production of DHT (which I
» » believe is at least as active as before the finasteride intake), is
» simply
» » insufficient to get this level to its previous value within, say, a day
» or
» » two.
»
» How can the "endocrine production of DHT" be just as active as before
» finasteride intake, once finasteride knocks-out most of the 5a-reductase
» type 2?
»
» » If your assumption was right, we should see a landing on the curve,
» » which we do not see.
»
» Can you explain what you mean by that a little better?
»
» » What's more if you look closely at the curves, you
» » can see how the average slope is way steeper for higher finasteride
» » concentrations, which explains why all curves get near one to the
» » other after 7 days.
»
» I wouldn't say that it's "way steeper".
»
» » It means that the more DHT you inhibit, the more fresh
» » dht is rapidly produced.
»
» Nah, I don't think so.
»
» » If not, explain to me how the 5mg finasteride
» » could be in the vicinity of the 0.2 or 0.04 mg after 7 days whereas
» » the DHT was way more severely suppressed in the first place.
»
» Because it only takes about 7 days to recover most (but not all) of the
» missing DHT.
»
» .

It is clear that Duta doesn't have the effect on scalp DHT compared to circulating DHT (even though it is effective at both, just more on DHT in circulation) This tells me that DUTA is not reaching the scalp and hair follicules as easily. One can ponder why that is, but this is the reason i think a topical duta may be more effective than oral. You know you will be getting the drug into places that oral may not be reaching as easily. I still have a suspicion that the drug may accumulate around the hair follicle for a longer period of time than just minutes as suggested.




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