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Topical dutasteride (Topicals & Shampoos)

posted by Bryan, 20.12.2007, 01:26

» It is clear that Duta doesn't have the effect on scalp DHT compared
» to circulating DHT (even though it is effective at both, just more
» on DHT in circulation)

I'm not sure if that's true or not, considering how there are conflicting numbers for levels of scalp/blood DHT reduction reported in different studies which have examined that question. I generally take those reported numbers with a grain or two of salt.

» This tells me that DUTA is not reaching the scalp and hair
» follicules as easily. One can ponder why that is...

Even if the numbers you previously cited for scalp DHT reduction versus blood DHT reduction are correct, I think you may be overlooking a possible simpler explanation for it, which is that it may reflect a much higher level of the type 1 enzyme within scalp skin sections than the type 2 enzyme. Considering how dutasteride is much less potent against type 1 than it is against type 2, that could possibly go a long way toward explaining those numbers, and it doesn't really have anything to do with how easily dutasteride is reaching scalp and hair follicles.

» but this is the reason i
» think a topical duta may be more effective than oral. You know you will be
» getting the drug into places that oral may not be reaching as easily. I
» still have a suspicion that the drug may accumulate around the hair
» follicle for a longer period of time than just minutes as suggested.

I really think that's just wishful thinking.


Bryan is located in [NA] and he is available to meet: NO

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