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Topical dutasteride (Topicals & Shampoos)

posted by rooster, 25.12.2007, 18:02

» » So the two questions for me:
» »
» » How fast would DHT resynthisize in the skin, aka scalp.
» After a course of finasteride? I think it's probably about the same as
» what was shown in that graph I posted previously to be the time required
» for blood levels of DHT to get back to normal after a dose of finasteride:
» about 1-2 weeks. It would take even longer after a course of dutasteride,
» obviously, because of dut's much longer half-life.
» » Secondly, does the enzyme bound by duta keep
» » the active duta in the area of the scalp for up
» » to a week or does it get systemically absorbed?
» I have no reason whatsoever to think that the bound enzyme would keep the
» active duta around the scalp for any extra length of time. As I said
» before, I think topically-applied dutasteride would be absorbed
» systemically within minutes, with the exception of a few dut molecules
» here and there which would be lucky enough to bind to hair follicle enzyme
» molecules on their way through the skin/scalp. The rest of them would go
» their merry way into the bloodstream, in my opinion.
» .

Phase 3 for oral duta is happening in Korea. Hopefully we can gleam some good info from the data.

rooster is located in [NA] and he is available to meet: NO

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