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Study: Estrogen plays a role in hair loss (Topicals & Shampoos)

posted by ipod, 05.01.2008, 20:39

This study is not really clear on how estrogen moderates hair loss but it sure does confirm that estrogen has a role to play in hair loss.

J Invest Dermatol. 2004 Jan;122(1):7-13.

Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage.

Ohnemus U, uNalan M, Handjiski B, Paus R.

Department of Dermatology, University Hospital Hamburg-Eppendorf, University of Hamburg, Hamburg, GermanyDepartment of Dermatology, Charite, Humboldt-University, Berlin, Germany.

Estrogen receptor ligands are important modulators of skin physiology and are involved in the control of normal hair follicle cycling. Here, we have studied the effects of topically applied 17-beta-estradiol on pathologic hair follicle cycling as seen during chemotherapy-induced alopecia, one of the major unresolved problems of clinical oncology. For this study we employed a well-established murine model that mimics chemotherapy-induced alopecia in humans. For precisely quantifying the area of hair loss and hair regrowth in this model in vivo, we developed a simple planimetric assay (dotmatrix planimetry). We show that topical 17-beta-estradiol significantly alters the cycling response of murine follicles to cyclophosphamide, whereas the estrogen antagonist ICI 182.780 exerted no such effects. Initially, topical 17-beta-estradiol enhanced chemotherapy-induced alopecia significantly by forcing the follicles into the dystrophic catagen response pathway to hair follicle damage, whereas follicles treated by ICI 182.780 or vehicle shifted into the dystrophic anagen response pathway. Consequently, the regrowth of normally pigmented hair shafts after chemotherapy-induced alopecia was significantly accelerated in the 17-beta-estradiol treated group. Our data encourage one to explore topical estrogens as a potential stimulant for hair re-growth after chemotherapy-induced alopecia.

PMID: 14962083




ipod is located in [NA] and he is available to meet: NO

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NW3 -
Propecia /Saw Palmetto
Topical Spiro / Rogaine Foam (quit REMOX IV)
High does vitamin C / Lysine / Nizoral / Tea Tree Oil Shampoo


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