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Avodart and DHT levels. (Drugs & Medications)

posted by Bryan, 03.04.2008, 22:44

» This question has been asked many many times. From the second set of graphs
» above, it seems obvious that dutasteride could be taken only once every 1,
» 2 or even 3 weeks without seeing any relevant change in the DHT serum
» level.

Sure, but only if you take an INCREASED DOSE (more than just a single Avodart capsule) once every 1, 2, or 3 weeks. To get the same amount of DHT suppression as taking an Avodart every day, you'd have to take 7 Avodart capsules once a week, or 14 Avodart capsules once every two weeks, or 21 Avodart capsules once every 3 weeks. See how it works? :-) You still have to get the same average dose of dutasteride, to achieve the same average level of DHT suppression.

» I remain a bit skeptical though about the long term efficiency. After
» all this drug has been designed against BPH and I imagine that Glaxo was
» aware of the apparent inertia of the DHT serum level after a single intake
» of dut.

I'm not sure what you mean by that. There's not much "inertia" after taking just a SINGLE Avodart capsule, because it obviously hasn't been building-up in the bloodstream for several weeks or months. But the "inertia" that you think you see after you've been taking it for a long time comes from the ACCUMULATED amount of the drug in your bloodstream, not any one single capsule that you happen to take on a given day.

» Why on earth did they adjust posology at one a day if one every
» 3 days was enough.

Because one Avodart capsule every 3 days is NOT enough! :-) Not enough to achieve the intended level of serum DHT reduction, anyway (about ~90% or so).

Dutasteride is a DOSE-DEPENDENT drug. You get increasingly more DHT suppression as the dose increases, thanks to the fact that it hangs around in the bloodstream so long.

.




Bryan is located in [NA] and he is available to meet: NO


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