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Flutamide (Drugs & Medications)

posted by mj2003 E-mail, Toronto, 10.12.2008, 23:46

Very informative stuff. Will definetly be doing research on it and loking into using it.

» » I never heard of Topical Flutamide. I have, however, had great results
» » with 5% minox. (i use up a bottle in 2 weeks and less) but i can't
» stand
» » the ess it leaves behind. Is Flutamide just as messy?
» Dermatol Surg. 2002 Aug;28(8):678-85.
» Fluridil, a rationally designed topical agent for androgenetic alopecia:
» first clinical experience.
» Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M.
» Radiology Research, University of California, San Diego, California, USA.
» Fluridil, a novel topical antiandrogen, suppresses the human androgen
» receptor. While highly hydrophobic and hydrolytically degradable, it is
» systemically nonresorbable. In animals, fluridil demonstrated high local
» and general tolerance.
» To evaluate the safety and efficacy of a topical anti- androgen, fluridil,
» in male androgenetic alopecia.
» In 20 men, for 21 days, occlusive forearm patches with 2, 4, and 6%
» fluridil, isopropanol, and/or vaseline were applied. In 43 men with
» androgenetic alopecia (AGA), Norwood grade II-Va, 2% fluridil was evaluated
» in a double-blind, placebo-controlled study after 3 months clinically by
» phototrichograms, hematology, and blood chemistry including analysis for
» fluridil, and at 9 months by phototrichograms.
» Neither fluridil nor isopropanol showed sensitization/irritation
» potential, unlike vaseline. In all AGA subjects, baseline anagen/telogen
» counts were equal. After 3 months, the average anagen percentage did not
» change in placebo subjects, but increased in fluridil subjects from 76% to
» 85%, and at 9 months to 87%. In former placebo subjects, fluridil increased
» the anagen percentage after 6 months from 76% to 85%. Sexual functions,
» libido, hematology, and blood chemistry values were normal throughout,
» except that at 3 months, in the spring, serum testosterone increased within
» the normal range equally in placebo and fluridil groups. No fluridil or its
» decomposition product, BP-34, was detectable in the serum at 0, 3, or 90
» days.
» Topical fluridil is nonirritating, nonsensitizing, nonresorbable, devoid
» of systemic activity, and anagen promoting after daily use in most AGA
» males.

mj2003 is located in TORONTO and he is available to meet: YES
email to arrange a meeting.

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