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Causes of Hair Loss (Hair Loss Supplements)

posted by Cole Kutz, 22.06.2011, 11:28

» "A considerable chunk of my work day is always spent answering people’s
» questions about prohormones and steroids. Of course, one of the biggest
» concerns people have is about estrogen and estrogen related side effects.
» Right behind that however are questions about DHT. It seems that people
» have the misconception that DHT is some evil androgen by product that
» serves no purpose in the body but to make our prostates blow up and our
» hair fall out.
» The real situation is of course much more complex. DHT is one of those good
» guy / bad guy hormones that is sorely misunderstood. For many people, it is
» NOT something that you want to reduce or eliminate in the body. For some
» others though, keeping DHT levels under control is probably a prudent
» course of action. Knowing the facts about DHT will help you decide just
» which group you belong to.
» Testosterone is a prohormone?
» The main androgen secreted by the testes is of course testosterone.
» However, in most of the body, the androgenic signal is not carried through
» by testosterone. In these tissues, which include the brain (CNS), skin,
» genitals – practically everything but muscle – the active androgen is
» actually DHT. Testosterone in this case simply acts as a prohormone that is
» converted to the active androgen DHT by the action of the enzyme 5alpha
» reductase (5-AR).
» 5-AR is concentrated heavily in practically every androgen dependent area
» of the body except for skeletal muscle. This results in very little
» testosterone actually getting through to these parts of the body to bind to
» androgen receptors. Instead, it is quickly transformed into DHT, which then
» interacts with receptors.
» This transformation serves a very important biological function in these
» tissues. You see, DHT is a much stronger androgen than testosterone – it
» binds about 3-5 times more strongly to the androgen receptor. If you took
» away 5-AR from these tissues and blocked the formation of DHT, then you
» would see some dramatic changes in physiology.
» A good case in point is demonstrated in male pseudohermaphroditism due to
» congenital 5-AR deficiency. This is a relatively rare disorder, however it
» is actually quite common in the Dominican Republic. In this disorder, males
» are born with little or no 5-AR enzyme. They have ambiguous genitalia and
» are often raised as girls. When puberty occurs, their testosterone levels
» elevate normally although their DHT levels remain very low. Their
» musculature develops normally like that of other adults, however, they end
» up with little or no pubic / body hair and underdeveloped prostate and
» penis. Their libido and sexual function is often disrupted also.
» Testosterone is the active androgen in muscle
» Skeletal muscle is unique from other androgen dependent tissues in the
» body. It actually contains little or no 5-AR, so little or no DHT is
» actually formed in the muscle. In addition to this, any DHT that is formed,
» or that is already present in the blood and travels to the muscle, is
» quickly deactivated by an enzyme called 3alpha-hydroxysteroid reductase
» (3a-HSD).
» So at least as far as muscle is concerned, testosterone is the primary
» active androgen. This is not to say that administering exogenous DHT is not
» without any anabolic effect. It actually does have some anabolic activity
» in the muscle, albeit significantly weaker than that of an equal amount of
» testosterone. This is due to its quick breakdown by 3a-HSD into the weak
» metabolite 5alpha-androstan-3a,17b-diol. If this enzyme were somehow
» blocked, it is likely that DHT would exhibit very potent anabolic effects
» on muscle.
» It is important to understand that even though testosterone is the active
» androgen in muscle, and DHT exhibits relatively little direct anabolic
» effects on muscle in men, DHT is still very important for the full
» performance enhancement effects from testosterone. What I specifically mean
» here are the effects of DHT on the central nervous system, which lead to
» increased neurological efficiency (strength), and increased resistance to
» psychological and physical stress - not to mention optimal sexual function
» and libido.
» I have heard several anecdotal reports of individuals who have stacked
» testosterone with proscar (a 5-AR inhibitor) and have noticed significantly
» reduced performance enhancement effects. What’s going on here? We know it
» couldn’t be due to the inhibition of the direct anabolic activity of
» testosterone on muscle anabolism. Most likely it is due to the reduction of
» androgenic effects in other parts of the body that contribute to the
» ergogenic effects, specifically the CNS, which is stimulated by androgens
» to increase neural output leading to greater strength and greater
» recoverability. Another possibility is a reduction in the production of
» androgen dependent liver growth factors (such as IGF-1), since DHT is an
» important androgen in the liver.
» Anti – Estrogen effects of DHT
» One important function of DHT in the body that does not get much discussion
» is its antagonism of estrogen. Some men that take Proscar learn this the
» hard way – by developing a case of gynecomastia. By reducing DHT’s
» protection against estrogen in the body, these men have fallen victim to
» its most dreaded ramification – bitch tits!
» How does DHT protect against estrogen? There are at least three ways that
» this likely occurs. First of all, DHT directly inhibits estrogens activity
» on tissues. It either does this by acting as a competitive antagonist to
» the estrogen receptor or by decreasing estrogen-induced RNA transcription
» at a point subsequent to estrogen receptor binding.
» Second of all, DHT and its metabolites have been shown to directly block
» the production of estrogens from androgens by inhibiting the activity of
» the aromatase enzyme. The studies done in breast tissue showed that DHT,
» androsterone, and 5alpha-androstandione are potent inhibitors of the
» formation of estrone from androstenedione. 5alpha-androstandione was shown
» to be the most potent, while androsterone was the least.
» Lastly, DHT acts on the hypothalamus / pituitary to decrease the secretion
» of gonadotropins. By decreasing the secretion of gonadotropins you decrease
» the production of the raw materials for estrogen production – testosterone
» and androstenedione (DHT itself cannot aromatize into estrogens). This
» property of DHT comes into particular utility when it is administered
» exogenously, and this is to be discussed in further detail in the next
» section.
» DHT, estrogen, and the prostate
» When it comes to sex hormones, few things are as misunderstood by the
» general consumer as the relationship of the prostate to DHT. The inaccurate
» and overly simplistic attitude that DHT is responsible for prostate
» hypertrophy, and even prostate cancer predominates amongst most people.
» The real situation is, of course, much more complex. One must understand
» that there are marked differences between healthy prostate growth
» (developmental growth), prostate growth due to BPH, and cancerous prostate
» growth.
» The first period of prostate growth, deemed developmental growth, is
» connected to puberty and the testicular secretion of androgens. This takes
» the prostate from its prepubertal dormancy to the normal sized, healthy,
» and functional prostate gland of an adult. During the early and mid adult
» years the prostate stays at this stage, despite the constant high levels of
» androgens in the body. However, if androgens are blocked in the body then
» the adult prostate will shrink in size. This can occur by castration, or
» even by blockade of 5-AR (recall that DHT is the active androgen in the
» prostate).
» Later in life, there is often a second stage of growth. This growth is
» deemed benign prostate hypertrophy (BPH) and this growth occurs in a wholly
» different hormonal environment than that of developmental growth. Evidence
» is mounting that the existence of a high estrogen / androgen ratio – a
» condition common in older men – is highly correlated to the development of
» BPH.
» Experimental studies have shown the inability of androgens with saturated A
» rings (DHT related) to induce an initial condition of prostate hypertrophy.
» These compounds are non-aromatizable. Aromatizable androgens on the other
» hand, such as testosterone or androstenedione can induce hyperplasic
» modifications of the prostate of monkeys, but these effects are reversed by
» the addition of an aromatase inhibitor.
» So apparently, estrogen is a causative factor in BPH or, probably more
» accurately, estrogen in the presence of a minimum, permissive amount of
» androgen.
» None of this may come as news to many of you, but I bet that very few of
» you know that DHT can actually be used to treat BPH!! How can it do that?
» It basically does this by replacing the testosterone in the body, which
» then has the effect of reducing the amount of estrogen in the body. As I
» started to explain before, DHT is a strong androgen that will signal the
» pituitary to decrease the production of gonadotropins. The decrease in
» gonadotropins will then cause less testosterone to be produced which will
» in turn cause the estrogen levels to drop. The resulting change in the
» hormonal milieu (high DHT, low estrogen) then apparently results in a
» regression of BPH.
» The clinical application of this theory is discussed in US patent 5,648,350
» "Dihydrotestosterone for use in androgenotherapy". The following
» illustrates the results:
» "In 27 subjects in which the plasma DHT level was controlled, so as to
» modulate the administered doses, said levels have been increased to 2.5 to
» 6 ng/ml. There resulted a decrease in gonadotrophy as well as in the plasma
» levels of testosterone which exceeded at least 1.5 ng/ml (from 0.5 to 1.4
» according to the case); as to the estradiol plasma levels, these decreased
» by 50%.
» Among this group of subjects, the volume of the prostate diminished
» significantly, as was evaluated by ultrasound and by PSA (Prostate Specific
» Antigen). The mean volume of the prostates was from 31.09.+-.16.31 grams
» before treatment and from 26.34.+-.12.72 grams after treatment, for a mean
» reduction of 15.4%, the treatment having a mean duration of 1.8 years with
» DHT (P=0.01)."
» This kind of flies in the face of the traditional thinking concerning BPH
» now doesn’t it?
» Conclusion
» People have a natural tendency to classify things as either good or bad,
» with no gray areas. DHT (like estrogen) has recently been on everyone’s bad
» list, and is often considered to be a hormone that serves no function in
» the body except to cause harm. As you can see, this view is far from the
» truth. In my opinion, the widespread use of 5-AR inhibitors such as Proscar
» as a prophylactic agent for people that really don’t need it should be
» reconsidered. So give DHT a break."

Don't say that too loudly. People will laugh at your moronic ass.

Cole Kutz is located in [NA] and he is available to meet: YES
email to arrange a meeting.

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