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Hair Loss Forum - Doxycycline

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KO

07.06.2013, 00:28
 

Doxycycline (Hair Multiplication & Stem Cells Treatment)

Doxycycline is the chemical Cots & Co. used to upregulate FGF9 in mice.




KO is located in [NA] and he is available to meet: NO

cody1212

07.06.2013, 19:34

@ KO

Doxycycline

Was it treated topically or orally? That is crazy, it's just an antibiotic that is super cheap and easily accessible...




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KO

08.06.2013, 00:40

@ cody1212

Doxycycline

Yeah seriously....looks like it was topically.




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GoneWithTheHair

Australia,
08.06.2013, 04:56

@ KO

Doxycycline

KO, where are you getting this info from do you have a link. thanks




GoneWithTheHair is located in AUSTRALIA and he is available to meet: NO

KO

08.06.2013, 05:04

@ GoneWithTheHair

Doxycycline

I have the FGF paper preview, not sure how to load it.

To test whether increased expression of Fgf9 in the wound promotes WIHN, we overexpressed Fgf9 in the epidermis of FVB-Tg(KRT14-rtTA)F42Efu/J; TRE-Fgf9-IRES-EGFP (K14rtTA; Fgf9) transgenic mice. Administration of doxycycline to these mice induces expression of Fgf9 targeted to the epidermis by the promoter for the gene encoding keratin-14. Fgf9 expression increased 150-fold in these mice after doxycycline administration (Fig. 1d), and this led to a marked increase in the number of neogenic hair follicles compared to controls (Fig. 1e,f). These combined results indicate that modulation of Fgf9 expression in the wound affects WIHN.


What is not clear to me is whether this only works on mice that are predisposed to overexpress the promoter for K-12.




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shivers20

08.06.2013, 05:24

@ KO

Doxycycline

Good find Ko! Thanks.




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AntiNorwood

08.06.2013, 08:30

@ KO

Doxycycline

Probably not for the a home experiment but someone like Dr Nigam could culture gamma-delta T-cells obtained from a patients blood in the presence of Isopentenyl pyrophosphate and obtain a high concentration of both the cells and FGF9. Injecting this may cause the human skin to simulate that of mouse more closely. Unfortunately the exact wounding process is not public knowledge.

Expression and synthesis of fibroblast growth factor-9 in human gamma-delta T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-β1/IL-15

http://www.jleukbio.org/content/75/4/657.long

gamma-delta T-lymphocytes are believed to play a role in maintaining the normal configuration of epithelial tissue. As little is known about the factors mediating this function, we addressed the question of whether gamma-delta T-lymphocytes produce fibroblast growth factor (FGF)-9 as well as two other growth factors associated with epithelial tissue reconstitution. Blood γδ T cells isolated from healthy donors were grown in the presence of isopentenyl pyrophosphate (IPP) or transforming growth factor-β1 (TGF-β1)/interleukin-15 (IL-15) for 24 h and were assessed for the expression and synthesis of FGF-9, keratinocyte growth factor (KGF), and epidermal growth factor (EGF). Resting human γδ T cells constitutively expressed KGF and FGF-9 mRNA but no EGF mRNA. In the presence of IPP, FGF-9 mRNA expression significantly increased in a dose-dependent manner, expression of KGF remained unaltered, and EGF mRNA could not be detected. In contrast to IPP, stimulation of the cells with TGF-β1/IL-15 did not alter FGF-9 expression. Moreover, stimulation with anti-CD3 does not induce FGF-9 expression but triggers a high signal of interferon-γ mRNA. Western blot analysis of γδ T cell lysates, prepared 4 days following stimulation with IPP, showed an increase of FGF-9 protein as compared with control cells. In conclusion, the results demonstrate for the first time that human blood and bronchoalveolar lavage γδ T-lymphocytes are capable of expressing FGF-9. The data also provide novel evidence that immunoregulatory cells can synthesize FGF-9.




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georgex6

GREECE ATHENS,
11.06.2013, 00:55

@ AntiNorwood

Doxycycline

www.xxxrlosshelp.com/forums/messageview.cfm?catid=10&threadid=80266&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear




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Freddie555

11.06.2013, 06:42

@ georgex6

Doxycycline

doxycycline is an anti-biotic like penicillin from what I remember.

if so, there should be no issue using it in humans - as its already used in humans.

but how many guys getting this as an anti-biotic grow hair ?




Freddie555 is located in [NA] and he is available to meet: NO

---
"When true Hair Multiplication comes, it will arise out of the East." - John The Revelator, Feb. 18, 2001

bug2

11.06.2013, 07:51

@ KO

Doxycycline

ugh

Doxycycline does not up-regulate fgf9. You need to look up what a transgenic mouse is. In very simple terms its a mouse that will over-express something when triggered by something else. In this case its a genetically modified mouse that over-expresses fgf9 when doxycycline as administered.

bug




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KO

11.06.2013, 14:16

@ bug2

Doxycycline

^Yep.




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