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Hair Loss Forum - HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

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roger_that

MARYLAND,
03.07.2013, 19:36
 

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible? (Hair Multiplication & Stem Cells Treatment)

HairSite, would it be possible to arrange an interview with either Dr. Cotsarelis or Dr. Garza, to ask them some questions about PGD2 inhibition and PGD2 blocking? I think this would be very helpful to HairSite members.

I suggest that the questions be pre-arranged in advanced, carefully selected, and that anyone who is disrespectful towards these two doctors be removed from the interview and/or the forum.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

walrus

03.07.2013, 20:51
(edited by walrus, 03.07.2013, 21:28)

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Good idea. If anything comes of this, my question for Dr. Cotsarelis would be:

Is it known if hairs from the back of the head lack the GPR44 receptor? If so, could this explain how transplanted hair is able to last in bald areas of the scalp (with presumably high levels of PGD2)?




walrus is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
03.07.2013, 22:15
(edited by roger_that, 03.07.2013, 22:37)

@ walrus

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Originally Posted by walrus

Good idea. If anything comes of this, my question for Dr. Cotsarelis would be:

Is it known if hairs from the back of the head lack the GPR44 receptor? If so, could this explain how transplanted hair is able to last in bald areas of the scalp (with presumably high levels of PGD2)?


I'm not an expert, but I can already tell you what I think the likely reply may be:

No, hair follicles in the back of the head aren't missing the GPR44 receptor.

The issue is that the cells in the balding areas (especially in those follicles) make much more PGD2 than normal, essentially a non-stop flood of PGD2.

The cells and follicles in back of the head have the same number of GPR44 receptors, and a NORMAL amount of PGD2, like the follicles of a person without MPB.

Full disclosure for those who say my answer above isn't sufficiently detailed: I should add that there is a possibility of upregulation of the GPR44 receptor in the balding areas, from overexposure to PGD2. This is only a possibility. It's called a positive feedback loop. In some instances in biochemistry, the exact opposite can happen, and overexposure to a certain signaling molecule might cause a downregulation in a receptor, which would be a negative feedback loop.

But I agree, that question and others like it should be put directly to Drs. Cotsarelis and Garza, as they're the true experts/visionaries in this stuff. My answer may be completely off.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

walrus

03.07.2013, 23:43
(edited by walrus, 04.07.2013, 00:08)

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

The issue is that the cells in the balding areas (especially in those follicles) make much more PGD2 than normal


Your answer is feasible, and this could well be the case if the majority of PGD2 synthesis is localised in the follicle itself.

But note from the Garza et al paper: 'We also detected PTGDS outside of the hair follicle epithelium, indicating potential sources of PGD2 in the dermis'

From this we may expect dermal derived PGD2 to inhibit transplanted and non-transplanted hairs alike - which of course, doesn't happen.




walrus is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
04.07.2013, 01:15

@ walrus

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

The issue is that the cells in the balding areas (especially in those follicles) make much more PGD2 than normal

Originally Posted by walrus


Your answer is feasible, and this could well be the case if the majority of PGD2 synthesis is localised in the follicle itself.

But note from the Garza et al paper: 'We also detected PTGDS outside of the hair follicle epithelium, indicating potential sources of PGD2 in the dermis'

From this we may expect dermal derived PGD2 to inhibit transplanted and non-transplanted hairs alike - which of course, doesn't happen.


Good point, and thanks for pointing that out. I think that most of the extra PDG2 that's synthesized is right inside the follicle, in the follicle's cells itself.

Some of the extra PGD2 found outside the follicles may be either from cells actually found in the tissue between follicles, or may also be "seepage" of PGD2 from the follicle.

In any event, ALL skin, all throughout the body, would be expected to have some native PGD2. PGD2 isn't made just inside balding follicles on the scalp, it's made throughout the whole body, especially in the skin, but also in the Central Nervous System, the brain, the heart, and other organs.

Remember, PGD2 is also part of the NORMAL hair growth cycle, even in non-balding follicles on your scalp, and even in every single person who doesn't have MPB.

The only difference is, in the scalps of balding people, the synthesis of PGD2 is much greater than in the scalps of non-balding people.

The reason that transplanted follicles don't (usually) miniaturize is that the small amount of PGD2 made or present in the tissues in-between balding follicles just isn't enough to destroy the transplanted follicles.

Remember that PGD2 has a VERY short half-life after it is synthesized, maybe a few seconds. Therefore the action of PGD2 (like all prostaglandins) is VERY localized with respect to where it's made. It can't have an effect too far away from where it's made. We're talking very tiny distances.

IMO the reason an affected follicle miniaturizes but a neighboring transplanted one does not is because there is simply a non-stop flood of PGD2 being synthesized locally in the MPB follicle.

Picture a million little water faucets that are ALWAYS turned on, always gushing with water (PGD2), non-stop, from the time a follicle starts to bald until your death.

The effect is continuous and uninterrupted, but the distance of the effect from the source is very tiny, so the effect is extremely localized with respect to the source.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

shivers20

04.07.2013, 02:46

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

I need two questions answered, Is PGD2 preventing stem cells from making progenitor cells? Does PGD2 caused hair follicles to gradually degenerate and form oily cysts, indicating that the HFSCs adopted a sebaceous gland fate and failed to self-renew.




shivers20 is located in [NA] and he is available to meet: NO

hairman2

04.07.2013, 09:36

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

The most interesting question of all to me would be whether or not Cots has tested available substances on animal or human models to examine what happens when PGD2 or the GPR44 is inhibited.




hairman2 is located in [NA] and he is available to meet: NO

HairlossCurse

04.07.2013, 11:17

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

This is a very good idea




HairlossCurse is located in [NA] and he is available to meet: NO

hairman2

04.07.2013, 11:49

@ HairlossCurse

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

It's probably also quite unrealistic that Cots or Garza will be interested in answering our queries. At least up until now they have not been very forthcoming with information.

Originally Posted by HairlossCurse

This is a very good idea





hairman2 is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
04.07.2013, 14:46

@ hairman2

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

It's probably also quite unrealistic that Cots or Garza will be interested in answering our queries. At least up until now they have not been very forthcoming with information.

Originally Posted by HairlossCurse

This is a very good idea

Originally Posted by hairman2


Dr. Cotsarelis sometimes does interviews. I seem to remember he even appeared here on HairSite very briefly a few times to contribute a bit to the forums.

What I object to, and I think this might be the primary reason he might be reluctant to appear here, is that a lot of the people on these boards are loose cannons and can be really rude and insulting, rather than respectful, to these doctors.

For instance, when a few people recently called Dr. Cole a racist, I think that was outrageous and completely uncalled for. Primarily because the statement by Dr. Cole they were criticizing was, on its face, not even racist.

Look, we can criticize these doctors all we want, regarding their technical abilities or their claims. That's part of what this forum is for.

But to make ad hominem attacks against people, which have absolutely nothing to do with the issues at hand (hair loss and treating hair loss), I think that is the main reason researchers would refrain from interacting with forum members in real time.

I would suggest a "virtual interview" by the moderator, a list of clear-cut questions, prepared in advance and presented to the doctors.

A real-time interview would be even better (it would be great because there could be greater interaction and back-and-forth), but I don't know if some people here could be trusted to be polite and respectful to the docs.

Sorry if I've indirectly insulted anyone here but that's just the way it is. I'm just telling the truth.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

hairman2

04.07.2013, 16:34

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Firstly, I certainly do not recall Cotsarelis ever having been on HairSite. I would be reaaaaaaaally surprised if someone proved me wrong on that.

Secondly, I did not call Dr Cole a racist, I said his comments were racist - and I stick to that. He may have said it without giving it much thought and maybe at the root of things a very open minded person. However, if your first and only association with a nation is to describe and refer to it as a treatment resistant disease infested sh*thole, then I think it is safe to say that that is a very negative stereotype and generalization of a whole nation and its people. How anyone can argue that such a negative generalization of a nations people does not constitute racist behavior, is beyond me. Anyway Dr Cole issued an apology which I think we should be willing to accept for the benefit of progress.

Back to the subject at hand however, the available interviews with Dr. Cotsarelis appeared very staged to me. Judging from the responses Dr Cotsarelis gave, it appeared that the inquiries were previously disclosed and that the interviewers posed no inconvenient or invasive questions (purely speculative). Everything he responded to seemed to be deliberately superficial.

It's probably also quite unrealistic that Cots or Garza will be interested in answering our queries. At least up until now they have not been very forthcoming with information.

Originally Posted by HairlossCurse

This is a very good idea

Originally Posted by hairman2


Originally Posted by roger_that


Dr. Cotsarelis sometimes does interviews. I seem to remember he even appeared here on HairSite very briefly a few times to contribute a bit to the forums.

What I object to, and I think this might be the primary reason he might be reluctant to appear here, is that a lot of the people on these boards are loose cannons and can be really rude and insulting, rather than respectful, to these doctors.

For instance, when a few people recently called Dr. Cole a racist, I think that was outrageous and completely uncalled for. Primarily because the statement by Dr. Cole they were criticizing was, on its face, not even racist.

Look, we can criticize these doctors all we want, regarding their technical abilities or their claims. That's part of what this forum is for.

But to make ad hominem attacks against people, which have absolutely nothing to do with the issues at hand (hair loss and treating hair loss), I think that is the main reason researchers would refrain from interacting with forum members in real time.

I would suggest a "virtual interview" by the moderator, a list of clear-cut questions, prepared in advance and presented to the doctors.

A real-time interview would be even better (it would be great because there could be greater interaction and back-and-forth), but I don't know if some people here could be trusted to be polite and respectful to the docs.

Sorry if I've indirectly insulted anyone here but that's just the way it is. I'm just telling the truth.





hairman2 is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
04.07.2013, 17:24

@ hairman2

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

OK, I agree that Dr. Cole's statement was a stereotype, but I don't think it was a racial stereotype, nor an ethnic one. It was more of a geographical and socioeconomic stereotype, something like "First World" vs. "Developing World".

I also think the statement was inappropriate in this context, and also, as Dr. Nigam correctly pointed out, inaccurate, coming from an American, when antibiotic restistant bacteria, including TB bacilli, are becoming more and more common in the USA, in large part due to overprescription and incorrect prescription of antibiotics by American doctors.

However, it's quite a jump from that to saying the statement was racist. The environment a people live in, the standards of health and prevalence of disease they're exposed to, are not caused by the race or ethnicity of the people.

Since Dr. Cole is a graduate of medical school and also has advanced clinical training, I would expect that he knows these things, and I'm sure he does. Therefore to instantly label his comments "racist" is to me, a ridiculous and inappropriate leap, and is quite irresponsible and destructive to the spirit of dialogue we're trying to foster here.

That is why, while I highly respect you, hairman, I referred to that kind of comment as "loose cannon" type of talk that is counterproductive and will only alienate these doctors from contributing to and cooperating with these forums.

I know you know better than that.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

HairSite

Homepage E-mail

04.07.2013, 17:33

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Will see what I can do, but cannot guarantee anything.

Thanks




HairSite is located in [NA] and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

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hairman2

04.07.2013, 17:34

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Originally Posted by roger_that

Since Dr. Cole is a graduate of medical school and also has advanced clinical training, I would expect that he knows these things, and I'm sure he does. Therefore to instantly label his comments "racist" is to me, a ridiculous and inappropriate leap, and is quite irresponsible and destructive to the spirit of dialogue we're trying to foster here.


agreed, which is why I didn't broach the topic until you called me out on it. Discussing it any further serves no purpose, particularly as Dr. Cole himself accepts that it was inappropriate.

Anyway it's cool that Dr Cole is keeping an open-minded and is willing to investigate Dr Nigams technique. If such a respected surgeon as Dr Cole were to promote Dr Nigams donor doubling, then I think that that might lead to the long awaited breakthrough for this technique for the entire HT industry.

I wonder if Dr Cole is only interested in the donor doubling techniques or if he is also interested in Dr Nigams cell based treatments as well.




hairman2 is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
04.07.2013, 17:42

@ hairman2

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Anyway it's cool that Dr Cole is keeping an open-minded and is willing to investigate Dr Nigams technique. If such a respected surgeon as Dr Cole were to promote Dr Nigams donor doubling, then I think that that might lead to the long awaited breakthrough for this technique for the entire HT industry.

I wonder if Dr Cole is only interested in the donor doubling techniques or if he is also interested in Dr Nigams cell based treatments as well.


I think he's interested in all of it. Anything Dr. Nigam has to offer. Also, these doctors all know that in most developed countries (the USA, Europe, etc. -- I don't know about India), use by a doctor of a medical procedure discovered by another doctor (even if it has been granted a patent) no longer constitutes patent infringement, so even if a doctor takes an entire medical procedure discovered and patented by someone else, and uses it on his patients, he cannot be successfully sued for infringement.

I think a lot of the general public, including most people on these hairloss forums, don't know that. In the US, that law was passed by Congress in 1996 and signed into law by President Clinton in 1997.

Dr. Cole and Dr. Nigam are not really competitors, since they operate in two entirely different regions of the world. The overlap of their prospective patients is nominal. If Dr. Cole were able to start a successful practice in Atlanta using Dr. Nigam's techniques, he would not be significantly harming Dr. Nigam's practice. Dr. Nigam is probably the most visible and successful aesthetic surgeon in Mumbai, the biggest city in a country of 1 billion people. It's not like Dr. Cole is going to take his patients away.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

roger_that

MARYLAND,
04.07.2013, 17:46

@ HairSite

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Originally Posted by HairSite

Will see what I can do, but cannot guarantee anything.

Thanks


Thank you from all of us!




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

06.07.2013, 15:22
(edited by FollicleSherlock, 06.07.2013, 16:06)

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

This is a great idea Roger.

There was some talk by Dr. Nigam & others at stop aga.com about bringing them in as members after bringing the hair societies in as members that Garza was Pres.& Cotsarelis belongs to, to provide a base to help meet its objectives of promoting the dissemination of state of the art knowledge on hair biology and to establish links with other international hair research societies and to arrange combined meetings on a periodic basis to educate both colleagues and the public on hair biology and the pathophysiology and treatment of hair related conditions.
With the idea to foster greater enhanced communication between bench scientists, clinicians, industry, patient support societies. --- I read. However this is an actual call to action on part of administration here at hairsite that we hope to find out the reply on this during the upcoming week I expect here at hairsite, bravo to admin of hairsite!:-)

Obviously what would be of interest is that there has been much experimentation with OC already in the experimental room at hlh forum, they may not be aware of as well as TM and it would be interesting to find out how they account for the lack of results from such, particularly since the chemical was tested at a lab and trialed, (granted I never saw a reading of the tests performed professionally for verification but that can easily be done).




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
06.07.2013, 15:38
(edited by roger_that, 06.07.2013, 16:12)

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Obviously what would be of interest is that there has been much experimentation with OC already in the experimental room at hlh forum, they may not be aware of as well as TM and it would be interesting to find out how they account for the lack of results from such, particularly since the chemical was tested at a lab and trialed, (granted I never saw a reading of the tests performed professionally for verification but that can easily be done).


The problem with that is, all that experimentation with OC is unauthorised at best. My take is that it's an experimental drug that's not yet on the market, or rather one company is synthesizing this drug and it may or may not be an authentic version thereof. Then there are several complicated questions about the legality of these experiments.

If Dr. Cotsarelis, for instance, were to visit a forum and forum members informed him that they were testing OC on themselves, number one, that would be an admission of guilt by these members of violating several laws. Second, it would put Dr. Cotsarelis in a very sticky situation of having to respond to a forum member discussing illegal activities with respect to a drug that's only in the clinical trials phase and hasn't yet been approved. The fact that it happens to be a drug or a class of drugs that Dr. Cotsarelis is currently trying to get approved just complicates things further.

Furthermore we don't know if this "OC" stuff being used in experiments is the real thing, or a poor facsimile of the drug, with for instance, an incorrect double bond in the molecule or something. Getting even one chemical bond wrong, or halogenating the wrong carbon atom is about 99% guaranteed to nullify the efficacy of the drug, period.

The other thing we don't know about is, is this "OC" being delivered with the right vehicle to ensure absorption through the skin.

Big questions and we don't have all the answers.

I think the questions posed to these doctors will have to be carefully considered and screened before the interview. A free-for-all format will not do.

(The other thing I should point out from your post is that I believe OC has been "tested at a lab and trialed", but for allergy, not for hair loss. I've heard of no results for hair loss trials of OC yet.)




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

06.07.2013, 16:23
(edited by FollicleSherlock, 06.07.2013, 17:02)

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

by OC tested at a lab, I mean poster mlouis of hlh and private forum, paid for testing of the OC being produced by Kane. This is the same OC members at hlh experimental were using on that huge thread there and continue with a thread now in the private forum on.
That test is posted on a thread in hlh experimental and perhaps in the private forum and can be found also by private messaging mlouis in the private forum for more details. So it is not for allergy but for verification that what they were using on their head was the real thing. Again reading of the test is important.t I understood OC to have been approved for human use, and the TM( a competing chem. that they are trialing now, not to be).

(roger, some members have sent you relevant material related to this in your private message box on the private forum, you may want to check, as they are following this thread you created)


TO HAIRSITE ADMIN and/or Roger_that and others setting this up, to have any hope of getting decent reliable message through to Dr. Cotsarelis may I suggest you contact by phone the Perlman Medical Center in Philadelphia and speak to the office Manager there where he works, they should be able to assist, emails I wouldn't waste your time http://www.med.upenn.edu/apps/faculty/index.php/g275/p19946
For Garza contacts for him and staff are here http://www.hopkinsmedicine.org/dermatology/research/basic_science/garza_lab/staff.html




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
06.07.2013, 17:14
(edited by roger_that, 06.07.2013, 17:36)

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

by OC tested at a lab, I mean poster mlouis of hlh and private forum, paid for testing of the OC being produced by Kane. This is the same OC members at hlh experimental were using on that huge thread there and continue with a thread now in the private forum on.


I know that certain internet vendors like the Kane Shop state that their products are tested in labs to validate the chemical composition, and they post graphical results of tests like gas chromatography and mass spectroscopy.

According to what you're saying, the testing paid for by mlouis was done privately and independently. Are there graphical results of the lab tests?


I understood OC to have been approved for human use, and the TM( a competing chem. that they are trialing now, not to be).


No, as far as I know, OC000459 is currently in trials for allergy and asthma, but has not yet been approved for any use.

Furthermore, it looks like one of their main markets for this drug will be Russia and the former Soviet Union states (CIS).

See the homepage of the manufacturer, Oxagen (a UK firm) which also holds the patent rights to this drug:

http://www.oxagen.co.uk/about.htm

This is an excerpt from their website:

Oxagen owns[, and will actively enforce and defend,] intellectual property rights relating to OC000459. Except for nominated sub-contractors, no company other than Oxagen has any rights to manufacture, market, use or sell OC000459, anywhere in the world.

Oxagen has no data at all, either pre-clinical or clinical, to support the therapeutic use of OC000459 in male-pattern baldness.


My take on this is that they will not take kindly to the unauthorised synthesis or use of this molecule, if they were to discover instances of it.

On the other hand, if it turns out the drug does work for MPB, I'm confident that they'd want to pursue that market aggressively.

It looks like Oxagen assigned all non-Russia/CIS rights to this drug to another UK firm, Atopix Therapeutics, Ltd:

http://www.atopixtherapeutics.co.uk/

They are currently nearing Phase III clinical trials for OC000459:

http://www.atopixtherapeutics.co.uk/04_02_pipeline.html

If this drug were already approved, doctors would be prescribing it (including as an off-label use for MPB) and people would be buying it on the open market right now.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

06.07.2013, 18:03

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

just pm him and or gansterboy aka boldy in member directory, they were graphical from what I recall and perhaps HNMR and HPLC, and 3rd party, he can direct you on the specifics and share a copy or where u can see it. Still have to be read of course by someone who can.




FollicleSherlock is located in [NA] and he is available to meet: NO

cal

06.07.2013, 22:43

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Trying to get an interview with Cots is a noble aspiration but I have my doubts about its usefulness. I think the guy already says as much as he intends to reveal about his research as it is. Aside from perhaps getting him to loosen up and surprise himself with what he says, I don't expect to get anything significant out of him that he hasn't said already. He chooses his public comments about his research too carefully.




cal is located in [NA] and he is available to meet: NO

FollicleSherlock

06.07.2013, 22:54
(edited by FollicleSherlock, 06.07.2013, 23:19)

@ cal

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

it's worth a shot, particularly with both Cots and Garza, nothing to lose, but end up right back where things are now, so nothing ventured, nothing gained.

- they may even stick around or come back on their own, as some members find chat addictive, or perhaps take up idea of promoting the hair societies to join the private they are part of, any connection at this point is progress:-)




FollicleSherlock is located in [NA] and he is available to meet: NO

Aran Linvail

07.07.2013, 00:53

@ cal

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

This. He will never say anything that isn't public information, nor will he try to help us run our "home experiments".




Aran Linvail is located in [NA] and he is available to meet: NO

---
Poster formerly known as "KO"

FollicleSherlock

07.07.2013, 01:24

@ Aran Linvail

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

He has never been asked the HARD questions by news reporters who don't even know the subject, and are all falling over themselves with how to spin an article with title of hair loss cure indeed, should be rather interesting or don't expect more,
if not interested don't tune in.




FollicleSherlock is located in [NA] and he is available to meet: NO

FollicleSherlock

07.07.2013, 17:53

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Roger as this does get underway, a list of questions have developed on the thread about this thread here of yours and linking to this thread in the main room of the private forum, please consider checking it and considering their questions as well for Dr. Cotsarelis and Dr. Garza.

they are questions from top posters of all the sites.

you will find the thread under "view active topics" or just ask on entering.




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
07.07.2013, 18:01
(edited by roger_that, 07.07.2013, 18:41)

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

FollicleSherlock, as far as I know, I haven't been admitted to "the private forum" yet. I did apply to become a member, but apparently my application was never responded to, or at least I haven't seen a response.

In any event, I am not big on checking hair loss forums apart from HairSite. I am a very busy person and I don't have the time to go around floating from forum to forum, much less to become a regular on all of them.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

08.07.2013, 01:10

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Originally Posted by roger_that

FollicleSherlock, as far as I know, I haven't been admitted to "the private forum" yet. I did apply to become a member, but apparently my application was never responded to, or at least I haven't seen a response.

In any event, I am not big on checking hair loss forums apart from HairSite. I am a very busy person and I don't have the time to go around floating from forum to forum, much less to become a regular on all of them.


you were admitted & account setup soon after Dr. Nigam and over 100 hairsite members joined to add to best members from all other sites, that is funny, you should have gotten an email, perhaps check your email spam folder, case goes for anyone else who signed up like poster Appleguy and didn't get in, your acts was set up June 23rd Roger you have pm's in your box there to, as many members from there and hairsite regulars were sending you pm's cos no pm here or live chatbox, but people still use both forums, just there for pm box & chatbox can't use here. Anyway if it isn't in your spam, figure you do what the rest of people do, just go to site and log in or email admin from site. I am not admin there, but site should work for you.

one of last places with pms cos hlh just got rid of their pms to.




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
08.07.2013, 01:42

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

And I'm telling you that I don't have the bandwidth for other hair loss sites, private messages, and all that.

After registering for that site, I checked my email in every way, shape and form, including my spam folder, day after day, and could find nothing remotely resembling a response from that website. I've done all kinds of searches in my archive and folders on every possible rendering of their name I can think of, and nothing came up.

I really don't have the time to spend much more effort in finding their invite, re-registering, contacting the site admin, or whatever else it would take for me to join that site. To be honest I don't have a huge amount of interest in it at this point. Whatever news surfaces on there will appear here after a few days latest, or possibly even before it appears there. I have a very busy, very active life and try not to spend all my time on a bunch of hair loss websites. One is doing quite enough for me right now.

If I find an email, in my thousands of emails in that inbox, that appears to be from that site, I'll pursue it, but I'm not going to spend hours looking for the damn thing. It's not that important to me.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

08.07.2013, 01:54

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

thomas.b.overgaard@gmail.com

this is address email would of came from or to send to I suspect as well, that is why it may of thrown you off. If you care to like you say look or get around to it, it should show up if run email search from email search box. But frankly, sure you can just go over to site with your username and password and log in otherwise I expect like anyone else can or follow link in email.




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
08.07.2013, 01:59

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

OK, thanks. I just noticed it and sent him a message asking how I can get on there. I honestly didn't even save my username and password. I really don't have the time to be drawn into lengthy discussions on other sites, though. I see this site, HairSite, as being enough for my needs.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

Aran Linvail

08.07.2013, 02:59

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Roger, you've been approved on that site, I can see your handle.




Aran Linvail is located in [NA] and he is available to meet: NO

---
Poster formerly known as "KO"

FollicleSherlock

08.07.2013, 03:03
(edited by FollicleSherlock, 08.07.2013, 03:44)

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

your username is roger_that, people are suppose to sign up as name on sites as you did.

right now forum is serving an unexpected secondary function as a free pm system for members of this site, baldtruth & now hlh since none of the foregoing have a pm system any longer and the private doesn't compete with them, as non revenue generating site with no ads, right now it's directing some traffic here by having a few threads doing further discussion about threads here like this one.,. in addition to regular items...anyway, all hairsite members are listed in member directory there that have joined, but you can see top most active posters listed on Dr. Nigams thread there, just ask on chat box if you don't see his current thread.


anyway, regarding this topic, I have had people such as Desmond84 the most prominent poster on baldtruth ask over on the private site today if there is anything at all he can do to assist in making this possible to please let him know over there in the private site by pm on the thread there, as he is completely supportive of this project of yours and your efforts here. So you may want to hit him up if you or hairsite needs additional help.




FollicleSherlock is located in [NA] and he is available to meet: NO

HairlossCurse

08.07.2013, 04:03

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

What is the story with this? Have they agreed?




HairlossCurse is located in [NA] and he is available to meet: NO

FollicleSherlock

08.07.2013, 16:13

@ HairlossCurse

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Garza was Pres. and assume still member of North American Hair Society.& Cotsarelis belongs to it as well one expects as does anyone who is serious about hair research that is N.A. based.

the stated objective of N.A. hair society is

to provide a base to help meet its objectives of promoting the dissemination of state of the art knowledge on hair biology and to establish links with other international hair research societies and to arrange combined meetings on a periodic basis to educate both colleagues and the public on hair biology and the pathophysiology and treatment of hair related conditions.
With the idea to foster greater enhanced communication between bench scientists, clinicians, industry, patient support societies.

as long as that is their objective, simply contact the N.A. Hair Society and request their presence here or in the private forum if it can't be arranged here for a public venue and lets get on with this.

or make an application to be a member if that is what you want and ask them yourself at next meeting or however they arrange contact

here is N.A. hair society http://nahrs.org/Membership.aspx

here Garza is on their Board of Directors until 2016 http://nahrs.org/AboutTheNAHRS.aspx along with many other names you've heard, I think one was Dr. Chriastiano and others you may want to invite to speak here or in the private forum.

Point being contact the N.A. Hair Society to get this going to




FollicleSherlock is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
08.07.2013, 17:28

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

FollicleSherlock, I think you're giving WAY too much importance to these so-called "hair societies". They aren't what you think. These researchers don't work for these societies day-to-day. The societies don't have the right or the power to grant an interview with these researchers. Most of these academic societies are just minor sideline activities for these doctors and researchers. Whatever anyone says (including their members), these academic societies are of vastly less importance than you seem to think. I won't get into the details as to why, but trust me on this.

On the other hand, trade associations like the International Society for Hair Restoration Surgery (ISHRS), which is not a true academic "society", but a lobbying group whose purpose is to promote the commercial interests of their members, ARE very powerful. But the ISHRS are not involved directly in the research we're trying to learn more about.




roger_that is located in MARYLAND and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

FollicleSherlock

09.07.2013, 21:15

@ roger_that

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Dr. Garza is currently on the Board of Directors and was past Pres. for North American Hair Society, so in his case their agenda and stated goals may mean more than the casual member, Reason I mentioned them, is that what you propose is fitting with their stated goals of reaching out to the public explaining hair physiology and related concepts I listed above. Granted the society may not occupy his day to day agenda and may not dictate what he does with his schedule, however as part of it at a senior level it may be another avenue instead of reaching out just directly to his clinic or laboratory that is perhaps commercial in interest only?

Finally where are we at with this invitation of Dr.Garza and Dr.Cotsarelis?

Secondly, Roger, you are missing out on the excitement right now about the HHAG trial, that is what is going on in the private room hourly with updates on progress and related growth factors. However I understand if you are on a limited schedule with visiting sites, it just would be great to have your input, but the growth trial is in it's 2nd month looking at pics being posted now on one of the participants & another joining the trial, that is where all the excitement is right now on all the forums on those threads.




FollicleSherlock is located in [NA] and he is available to meet: NO

FollicleSherlock

12.07.2013, 02:10

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

What's happening with this, have garza or cotsarelis responded and have they been contacted, and how?




FollicleSherlock is located in [NA] and he is available to meet: NO

georgex6

GREECE ATHENS,
13.07.2013, 11:31

@ FollicleSherlock

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

i think dr Nigam can help because he met him in scotland last may




georgex6 is located in GREECE ATHENS and he is available to meet: NO

HairlossCurse

31.07.2013, 13:25

@ georgex6

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Roger_that is an update available?




HairlossCurse is located in [NA] and he is available to meet: NO

Researcher

12.08.2013, 18:31

@ HairlossCurse

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Originally Posted by HairlossCurse

Roger_that is an update available?


Gosh, this sounds like such a big deal to have someone log in for a few minutes and answer some questions.

These guys likely are too busy picking up shirts from drycleaners or perhaps I understand, they were filling up on gas instead of answering some questions, or perhaps Dr. Cotsarelis was busy having quality elevator time conversation on the way up at UPenn...

Dr. Cotsarelis, sure you have a net connection, could you take a break from checking emails and log in for a sec... Hello!!

Dr. Cotsarelis this post is meant with full respect of course, but come' on, I am sure a Dermatologist can find a minute in his day to answer a few intelligent questions from the world at large.




Researcher is located in [NA] and he is available to meet: NO

cal

14.08.2013, 11:45

@ Researcher

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

These guys have the time. They lack the willingness to divulge anything.




cal is located in [NA] and he is available to meet: NO

georgex6

GREECE ATHENS,
03.09.2013, 08:46

@ cal

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Guys i emailed yesterday luis garza telling him that our community wants an intereview and very friendly he told me to email him the questions to answer.I have done this in the past so guys start to write your questions to send to him




georgex6 is located in GREECE ATHENS and he is available to meet: NO

hairman2

03.09.2013, 10:28

@ georgex6

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Great news george.

The main question for me is:

We know from Cots and Garzas publication that exposure of hair follicles to PGD2 has shown to result in complete inhibition of hair growth.

What we do not know however, is whether or not it has been observed that antagonism of the CRTH2 receptor actually can spur hair growth, or at least prevent further hair loss.

It would be great to know whether or not Dr Garza or his colleagues have conducted further research in this direction.



Originally Posted by georgex6

Guys i emailed yesterday luis garza telling him that our community wants an intereview and very friendly he told me to email him the questions to answer.I have done this in the past so guys start to write your questions to send to him





hairman2 is located in [NA] and he is available to meet: NO

HairlossCurse

03.09.2013, 10:53

@ hairman2

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Q: Do you have an update on the when the clinical trial will begin?
Q: MPB hair follicles grow as normal on immunodeficient mice is this because they do not produce pgd2?
Q: Why dont transplanted hairs get affected by pgd2?
Q: Do you plan on testing(in the clinical trial) pro-growth factors (eg pge2) as well?
Q: hairmans question




HairlossCurse is located in [NA] and he is available to meet: NO

hairman2

03.09.2013, 11:04

@ HairlossCurse

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

excellent questions hairlosscure


Originally Posted by HairlossCurse

Q: Do you have an update on the when the clinical trial will begin?
Q: MPB hair follicles grow as normal on immunodeficient mice is this because they do not produce pgd2?
Q: Why dont transplanted hairs get affected by pgd2?
Q: Do you plan on testing(in the clinical trial) pro-growth factors (eg pge2) as well?
Q: hairmans question





hairman2 is located in [NA] and he is available to meet: NO

AleMB81

03.09.2013, 14:27

@ hairman2

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

My question is: "Did you see if finasteride lowered the PGD2 levels"?




AleMB81 is located in [NA] and he is available to meet: NO

Aran Linvail

03.09.2013, 18:08

@ georgex6

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

-You have demonstrated that Neogenesis+Lithium creates "neogenic-like" hair follicles in vivo in humans. Do these automatically become terminal hairs or is there another treatment necessary?

-Is inhibiting production of PGD2 a more promising pathway or inhibiting the CRTH2 receptor?




Aran Linvail is located in [NA] and he is available to meet: NO

---
Poster formerly known as "KO"

cal

04.09.2013, 02:49

@ Aran Linvail

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

" -You have demonstrated that Neogenesis+Lithium creates "neogenic-like" hair follicles in vivo in humans. Do these automatically become terminal hairs or is there another treatment necessary?"


The DIY experimenters' lack of regrowth with topical Lithium has answered that question pretty clearly. But it's worth asking Cots about it.


I think whatever is being created by that process is not close to viable topical follicles. I also doubt that Cots will ever give away anything too useful.




cal is located in [NA] and he is available to meet: NO

Aran Linvail

04.09.2013, 03:00

@ cal

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Indeed, but it also seems that Follica knew it would grow primitive follicles, which begs the question....why? And how do we get from there to terminal?




Aran Linvail is located in [NA] and he is available to meet: NO

---
Poster formerly known as "KO"

Dogstar

04.09.2013, 06:41

@ Aran Linvail

HairSite: Is an Interview with Dr. Cotsarelis or Dr. Garza Possible?

Not much, but I saw a link to this article posted on xconomy yesterday.

http://www.the-scientist.com/?articles.view/articleNo/37149/title/A-Hair-Raising-Solution-/




Dogstar is located in [NA] and he is available to meet: NO

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