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Christopher1

24.10.2015, 01:25
 

JAK inhibitors grow hair - Dr. Christiano (Hair Multiplication & Stem Cells Treatment)

http://medicalxpress.com/news/2015-10-blocking-enzymes-hair-follicles-growth.html




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Christopher1

24.10.2015, 01:49

@ Christopher1

JAK inhibitors grow hair - Dr. Christiano

Interestingly I got on tofacitinib six weeks ago to try to treat vitiligo. These drugs are turning out to be huge success stories in a variety of autoimmune disorders. A few points:

First, in the last two weeks I have noticed less hair fallout than usual. Hard to judge anything on such a short-term basis. The article does not clarify whether oral administration might produce results. Depends on what organs the drugs become active in, but since it is being used to treat a skin disorder, vitiligo, I would assume it likely reaches the follicles, in some amount.

Second, so you know, these drugs are very expensive if you don't have insurance.

Lastly, it is obviously unclear whether there is any new hair growth from this drug, based on this study. It looks as if it just activates present hairs to speed up the growth cycle, which might cause them to fall out faster as well. It's difficult to draw a lot of conclusions at this point, but if I find an appropriate topical vehicle I might crush some up and see what happens. Suggestions for the vehicle are welcome.




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tembo

24.10.2015, 04:18

@ Christopher1

JAK inhibitors grow hair - Dr. Christiano

Very interesting Christopher. Let us know if it improves your vitiligo and if you get any side effects. Did your doctor prescribe you the drug? Dr. Christiano also seems to have started a new company per this:

http://www.hairlosscure2020.com/huge-development-ruxolitinib-and-tofacitinib-could-also-regrow-hair-in-androgenic-alopecia/




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roger_that

MARYLAND,
24.10.2015, 14:38

@ Christopher1

JAK inhibitors grow hair - Dr. Christiano

I think this may be promising (and I am usually very skeptical of topicals and chemicals these days because most of them produce inconsistent results).

While Janus Kinases have a number of different roles, it may be that they're involved in hair growth signaling (perhaps downstream of the prostaglandins?)

Dr. Christiano's statement that some drugs and signaling agents which activate the growth phase of dormant follicles (I think you can include Minoxidil and PGE2 in this category), by experience, usually work in an uneven and sometimes patchy or unpredictable way, as opposed to this JAK inhibitor which is producing even, very substantial hair growth by switching the growth phase from telogen to anagen.

Remember that the very final step in most kinds of hair loss (different types of alopecias including MPB) entails signaling the follicle to have much shorter growth phase, and remain in dormant phase for longer and longer periods. So ultimately when you have MPB, the affected follicles have insignificant growth phases and very long resting phases. That results in shedding, shorter and shorter, finer and finer hairs until the follicle no longer produces a hair.

DHT sensitivity seems to trigger a pathway which involves things like PGG2 Synthase, excess PGD2 production (and possibly suppressed PGE2), and a few other things, all of which ultimately suppress the activiity of stem cells, reducing the numbers of progenitor and DP cells, which mimics a dormant follicle.

Now it looks like Janus Kinase (JAK) is involved. What is very interesting here as Dr. Christiano says, is the evenness and extent of the regrowth, which to me, suggests that JAK is located very far downstream in this complicated mess. Maybe it's the final biochemical step, or one of the last, before stem cell suppression?




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Follicular

25.10.2015, 05:20

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

I agree, this particular development seems much more significant - and promising - than the usual 'mouse' studies. Here's hoping.




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bugler

25.10.2015, 07:21

@ Follicular

JAK inhibitors grow hair - Dr. Christiano

Hi,

I found this Pilot Study to Evaluate the Efficacy of Ruxolitinib in Alopecia Areata done in 2013.

Funny but apparently they didn't publish the result. If so why was that?

https://clinicaltrials.gov/ct2/show/NCT01950780




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---
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roger_that

MARYLAND,
25.10.2015, 15:39
(edited by roger_that, 25.10.2015, 15:57)

@ tembo

JAK inhibitors grow hair - Dr. Christiano

Actually if you watch Dr. Christiano's long video on the original post where she gives a detailed explanation, she says they've found that the drug has an anti-immune effect, in that it suppresses T-cells, but that the surprising finding they made was that it also has a non-immune effect, in that it directly activates stem cells and switches the follicle out of resting phase into anagen or growing phase. This is something that was totally unexpected and it's not surprising Dr. Cotsarelis didn't expect it.

In light of that, Dr. Christiano indicated in her video that this JAK inhibitor should work just as well for MPB as it will for alopecia areata.




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jarjarbinx

25.10.2015, 18:56

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

Are there JAK inhibitors in the marketplace or soon to be in the marketplace? The drug would have to be potent and pure. We would have to be able to turn it into a topical solution.




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roger_that

MARYLAND,
25.10.2015, 22:16

@ jarjarbinx

JAK inhibitors grow hair - Dr. Christiano

Both roxafitinib and tocafitinib are approved and available on the market right now for autoimmune disorders like psoriasis.




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superhl

26.10.2015, 00:42

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

I will get excited when I see hair growing on humans! How many times have we heard this? They always say "more studies are needed". Take one human and try it. Just one. If a bald head returns to a full head of hair, then I will believe.




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epiker0

26.10.2015, 05:50

@ superhl

JAK inhibitors grow hair - Dr. Christiano

This sounds pretty exciting-of course if it works on humans. The great thing is that they're already FDA approved...as someone mentioned earlier, just has to get turned into a topical.

At the same time though, I think its best they go through with clinical trials-just in case they lead to some unexpected adverse reaction.

Also I've heard these drugs are very expensive, but I'll bet that's because the market is very limited.

Hopefully the makers of the drug will realize they can make a vast amount of money due to hundreds of millions of balding potential customers and make it affordable/cheaper.

It's true what they say, beauty is wasted on the youth. I had a full head of hair in my late teens and 20s-I could've take better advantage of it, but you never realize how fast time flies and how quickly one's looks can change-I'm in my early 40s now.

If I could get my hair back and get back into shape (which isn't hard), then I'll get a second chance with the sexy ladies and do it right this time. God I can't believe how stupid I was and squandered what I had.




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matigol

26.10.2015, 15:19

@ epiker0

JAK inhibitors grow hair - Dr. Christiano

nothing to hype for us. maybe for mice or for ppl suffering alopecia areata

right now it`s not very interesting for us




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roger_that

MARYLAND,
26.10.2015, 17:26

@ matigol

JAK inhibitors grow hair - Dr. Christiano

Matigol, did you watch Dr. Christiano's video? She mentions it will likely work for MPB. That's the whole point of this new discovery, that it works better to regrow hair as a topical than orally, which is not what was originally thought. Otherwise JAK inhibitors would be old news.




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matigol

26.10.2015, 21:28

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

no, I didn't watch the video. But don't they always mention that a new discovery MAY work in humans and not only in mice? or it MAY work for AA.

My expectations are not really big. But let`s hope.




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bugler

27.10.2015, 02:33

@ matigol

JAK inhibitors grow hair - Dr. Christiano

Any volunteer to get ruxolitinib (the other one has terrible side effects) and try it?




bugler is located in [NA] and he is available to meet: NO

---
Who did 911: https://www.youtube.com/watch?v=YC8j-uvZUI0

News

28.10.2015, 00:44

@ bugler

JAK inhibitors grow hair - Dr. Christiano

Does that mean she's not working on the 3D culturing of dermal papilla cells anymore? (That would be a shame, as I thought that was a much more promising approach.)




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News

28.10.2015, 00:55

@ News

JAK inhibitors grow hair - Dr. Christiano

Also, how long have these drugs been around to treat vitiligo? Are they used topically to treat vitiligo? (If so, then surely we would know by now if they had any effect on hair growth.)




News is located in [NA] and he is available to meet: NO

roger_that

MARYLAND,
28.10.2015, 01:12

@ News

JAK inhibitors grow hair - Dr. Christiano

On your question about Dr. Christiano's 3D cloning research, just a guess, but I suspect that she knows that Sanford-Burnham and possibly Shiseido may have rendered that somewhat irrelevant.

With respect to the drugs like tofacitinib fot vitiligo, yes I think they were being given orally, strange as it may seem.

One possible very negative side effect I could potentially see happening from this, though, is possibly causing a "rebound vitiligo"-like syndrome if the drug is withdrawn, even in a healthy person who's never had vitiligo. I have absolutely no idea if this would happen, but there are many examples of drug withdrawal/rebound effects in pharmacology.




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superhl

28.10.2015, 03:27

@ News

JAK inhibitors grow hair - Dr. Christiano

Originally Posted by News

Does that mean she's not working on the 3D culturing of dermal papilla cells anymore? (That would be a shame, as I thought that was a much more promising approach.)


As she stated in a previous interview, very difficult to get funding for cell culturing. Drugs that are already approve that show somewhat hope are more likely to get funded. The cell culturing is still a crap shoot. Hopeful but not there yet.




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RiuraO

E-mail

Spain,
28.10.2015, 13:18

@ superhl

JAK inhibitors grow hair - Dr. Christiano

I am not an expert, but it seems that molecular size makes possible a dermal administration of the drug without any problem..... Any volunteer ?




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jarjarbinx

29.10.2015, 04:00

@ RiuraO

JAK inhibitors grow hair - Dr. Christiano

I don't know much about this avenue of hair loss research but I do know that you will need specific information before doing a DIY experiment with a drug. We need to know what the drug is soluble in and we need to know the correct dose to use.

Unfortunately we do not know what these medicines are soluble in and we have no idea what dose would be needed. We could probably find out what it's soluble in because they probably tested that, but it's doubtful that anyone has tested what doses applied topically produces the desired local biological effect.




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Dogstar

29.10.2015, 11:00
(edited by Dogstar, 29.10.2015, 11:43)

@ jarjarbinx

JAK inhibitors grow hair - Dr. Christiano

I don't think we're going to get anywhere just slapping this stuff on our scalps and hoping for the best, like DR. Christiano said,

"More work needs to be done to test formulations of JAK inhibitors specially made for the scalp to determine whether they can induce hair growth in humans."

http://www.sciencedaily.com/releases/2015/10/151023174914.htm

The way they're forumlated is going to be extremely difficult to figure out at home, unfortunately, we're stuck waiting again. I'm all for home experimenting, if you know what you're looking for, but there's not much to go on here. If they need to be specially formulated for the scalp, I can't see crushing up the oral medicine, and mixing it with a topical being of much use.




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ESP2

E-mail

29.10.2015, 19:49

@ jarjarbinx

JAK inhibitors grow hair - Dr. Christiano

Agreed, but hard not to wonder if the getfitinib or another similar protocol (including the wounding and time-window for topical application) that some guys tried a couple of years ago would work with these drugs if the right mixture could be figured out.




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roger_that

MARYLAND,
30.10.2015, 22:00

@ Christopher1

Reason for baldness in these mice?

Anyone know what the cause of the baldness was in the mice in these photos?




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cal

30.10.2015, 23:35

@ roger_that

Reason for baldness in these mice?

Agreed, but hard not to wonder if the getfitinib or another similar protocol (including the wounding and time-window for topical application) that some guys tried a couple of years ago would work with these drugs if the right mixture could be figured out.



It very well might work.

But IIRC Gefintib isn't cheap without an insurance company picking up the check. I think at least one of the guys playing with a few years ago it was taking grapefruit juice at the time just to artificially jack up its effectiveness (liver) to hold down the expense of a steady internal dose for a few weeks.


I'm about ready to declare the UVB sunburn as a necessary component. Swisstemples is using it. The Gefitnib patients both had regrowth in locations/patterns that looked like common sunburn possibilities, and there was no other obvious explanation for what their patterns were. They had not been trying to regrow hair when it happened to them. I haven't written off dermbrasion working too but I think the evidence is mounting for the role of a UVB burn.

On that note, the Gefitnib patients were probably not re-burning exactly those same areas consistently for months on end. Yet their regrowth looked quite thick & dark. I suspect if we really nailed down this protocol then any sunburning required might only need to happen once or twice.

Follica seemed to have settled on plucking a bunch of hairs (vellus is okay) from the wound area about 2-3 days beforehand. That might help boost results.




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roger_that

MARYLAND,
31.10.2015, 13:15

@ jarjarbinx

JAK inhibitors grow hair - Dr. Christiano

Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist.




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jarjarbinx

01.11.2015, 19:02

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

Originally Posted by roger_that

Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist.



I don't think you can get a pharmacist in the civilized world to do this.

Also, when I said that science first needs to find out what dose produces the desired effect what I meant was that scientists would use a piece of detached human skin or human skin grafted to mice and apply the topicalized (liquid) version of the drug to it. The scientists would be looking to see what dose effectively blocks the enzymes they're trying to block, and they would be watching what effect doing so has on the human follicles inside the skin. This would involve biopsies and stuff like that. I'm talking about pre-clinical basic science.

I don't think you're going to get a pharmacist in the civilized world to do what you're suggesting until more basic science is performed with this treatment concept.




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roger_that

MARYLAND,
01.11.2015, 22:41

@ jarjarbinx

JAK inhibitors grow hair - Dr. Christiano

Originally Posted by roger_that

Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist.

Originally Posted by jarjarbinx



I don't think you can get a pharmacist in the civilized world to do this.

Also, when I said that science first needs to find out what dose produces the desired effect what I meant was that scientists would use a piece of detached human skin or human skin grafted to mice and apply the topicalized (liquid) version of the drug to it. The scientists would be looking to see what dose effectively blocks the enzymes they're trying to block, and they would be watching what effect doing so has on the human follicles inside the skin. This would involve biopsies and stuff like that. I'm talking about pre-clinical basic science.

I don't think you're going to get a pharmacist in the civilized world to do what you're suggesting until more basic science is performed with this treatment concept.


Jarjar -- I understand what you're saying. This was just a suggestion for a "quick and dirty" approach to getting this stuff tested as soon as possible, even if the testing is somewhat risky and may not yield results as accurate and reliable as we want. It seems you're always looking ways we can get things done fast, with minimal waiting and expense, so I just thought I'd throw the idea out there as a suggestion. I totally agree that few pharmacists in the "civilized world" might want to do this, but these days you never know. We could even get someone in Russia, Eastern Europe, China, etc., where people are much less worried about lawsuits, but places that still have some well-trained lab scientists and pharmacists/pharmacologists. Just an idea.

As for your suggestion, yes, I realize that would be the way to go, but again, waiting for someone to do in vitro skin testing, biopsies, etc., will take a long time. I assume Dr. Christiano's on this, but who knows how long it'll be before she publicly comes out with some results? 6 months? A year? Who knows? It's not likely to be very soon, though. She'll have to get funding squared away, and will likely only announce results in a formal journal article, which will take many months if not more than a year to complete.




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James Bond

02.11.2015, 18:42

@ roger_that

JAK inhibitors grow hair - Dr. Christiano

Based on the rate of progression of her other research, I estimate it will take her about 5 years to figure out if it works safely on MPB patients. Add in another 10 years of screwing around with the FDA and other entities before it's released as a cure. (If this seems like a long time to you, keep in mind that all involved will need at least 10 years factored in just to sit around on their fat asses.)

So 15 years for her to accomplish what I could easily accomplish offshore in a year-and-a-half. Of course, the outcome would not be a cure for MPB. It would be another treatment choice that would be viewed as better than Propecia in results but the side affects would be worse.

In order for this stuff to work well, it needs to be manipulated into a form with minimal side effects and maximum efficacy. I could accomplish this offshore in 2.5 years, but it will take the mainstream medical blobs about 25 years to get to the same place. This fits my standard rule that medical red tape adds about 10x to the length of time necessary to come up with new treatments.




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ESP2

E-mail

03.11.2015, 03:45

@ James Bond

JAK inhibitors grow hair - Dr. Christiano

JB:

A few questions:

-what side effects would you anticipate?
-how many test subjects?
-any idea of the ballpark costs that would need to be raised?




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jarjarbinx

04.11.2015, 07:13

@ ESP2

JAK inhibitors grow hair - Dr. Christiano

Originally Posted by ESP2

JB:

A few questions:

-what side effects would you anticipate?
-how many test subjects?
-any idea of the ballpark costs that would need to be raised?


We could probably get info about what the stuff is soluble in but how will you figure out what dose (%) you will use? For example, minoxidil is 5%. How will you determine what % you need in order to block the enzymes in the scalp that you want to block?




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News

05.11.2015, 20:49

@ James Bond

JAK inhibitors grow hair - Dr. Christiano

If it takes them 25 years to develop this treatment, they needn't worry about the side effects, because by then Sanford-Burnham's stem cell treatment will (probably) be on the market, and no one's going to use a topical treatment....




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