Christopher1 24.10.2015, 01:25 |
JAK inhibitors grow hair - Dr. Christiano (Hair Multiplication & Stem Cells Treatment) |
http://medicalxpress.com/news/2015-10-blocking-enzymes-hair-follicles-growth.html |
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Christopher1 24.10.2015, 01:49 @ Christopher1 |
JAK inhibitors grow hair - Dr. Christiano |
Interestingly I got on tofacitinib six weeks ago to try to treat vitiligo. These drugs are turning out to be huge success stories in a variety of autoimmune disorders. A few points: |
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tembo 24.10.2015, 04:18 @ Christopher1 |
JAK inhibitors grow hair - Dr. Christiano |
Very interesting Christopher. Let us know if it improves your vitiligo and if you get any side effects. Did your doctor prescribe you the drug? Dr. Christiano also seems to have started a new company per this: |
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roger_that MARYLAND, 24.10.2015, 14:38 @ Christopher1 |
JAK inhibitors grow hair - Dr. Christiano |
I think this may be promising (and I am usually very skeptical of topicals and chemicals these days because most of them produce inconsistent results). |
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Follicular 25.10.2015, 05:20 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
I agree, this particular development seems much more significant - and promising - than the usual 'mouse' studies. Here's hoping. |
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bugler 25.10.2015, 07:21 @ Follicular |
JAK inhibitors grow hair - Dr. Christiano |
Hi, --- |
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roger_that MARYLAND, 25.10.2015, 15:39 (edited by roger_that, 25.10.2015, 15:57) @ tembo |
JAK inhibitors grow hair - Dr. Christiano |
Actually if you watch Dr. Christiano's long video on the original post where she gives a detailed explanation, she says they've found that the drug has an anti-immune effect, in that it suppresses T-cells, but that the surprising finding they made was that it also has a non-immune effect, in that it directly activates stem cells and switches the follicle out of resting phase into anagen or growing phase. This is something that was totally unexpected and it's not surprising Dr. Cotsarelis didn't expect it. |
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jarjarbinx 25.10.2015, 18:56 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
Are there JAK inhibitors in the marketplace or soon to be in the marketplace? The drug would have to be potent and pure. We would have to be able to turn it into a topical solution. |
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roger_that MARYLAND, 25.10.2015, 22:16 @ jarjarbinx |
JAK inhibitors grow hair - Dr. Christiano |
Both roxafitinib and tocafitinib are approved and available on the market right now for autoimmune disorders like psoriasis. |
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superhl 26.10.2015, 00:42 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
I will get excited when I see hair growing on humans! How many times have we heard this? They always say "more studies are needed". Take one human and try it. Just one. If a bald head returns to a full head of hair, then I will believe. |
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epiker0 26.10.2015, 05:50 @ superhl |
JAK inhibitors grow hair - Dr. Christiano |
This sounds pretty exciting-of course if it works on humans. The great thing is that they're already FDA approved...as someone mentioned earlier, just has to get turned into a topical. |
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matigol 26.10.2015, 15:19 @ epiker0 |
JAK inhibitors grow hair - Dr. Christiano |
nothing to hype for us. maybe for mice or for ppl suffering alopecia areata |
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roger_that MARYLAND, 26.10.2015, 17:26 @ matigol |
JAK inhibitors grow hair - Dr. Christiano |
Matigol, did you watch Dr. Christiano's video? She mentions it will likely work for MPB. That's the whole point of this new discovery, that it works better to regrow hair as a topical than orally, which is not what was originally thought. Otherwise JAK inhibitors would be old news. |
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matigol 26.10.2015, 21:28 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
no, I didn't watch the video. But don't they always mention that a new discovery MAY work in humans and not only in mice? or it MAY work for AA. |
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bugler 27.10.2015, 02:33 @ matigol |
JAK inhibitors grow hair - Dr. Christiano |
Any volunteer to get ruxolitinib (the other one has terrible side effects) and try it? --- |
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News 28.10.2015, 00:44 @ bugler |
JAK inhibitors grow hair - Dr. Christiano |
Does that mean she's not working on the 3D culturing of dermal papilla cells anymore? (That would be a shame, as I thought that was a much more promising approach.) |
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News 28.10.2015, 00:55 @ News |
JAK inhibitors grow hair - Dr. Christiano |
Also, how long have these drugs been around to treat vitiligo? Are they used topically to treat vitiligo? (If so, then surely we would know by now if they had any effect on hair growth.) |
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roger_that MARYLAND, 28.10.2015, 01:12 @ News |
JAK inhibitors grow hair - Dr. Christiano |
On your question about Dr. Christiano's 3D cloning research, just a guess, but I suspect that she knows that Sanford-Burnham and possibly Shiseido may have rendered that somewhat irrelevant. |
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superhl 28.10.2015, 03:27 @ News |
JAK inhibitors grow hair - Dr. Christiano |
![]() Does that mean she's not working on the 3D culturing of dermal papilla cells anymore? (That would be a shame, as I thought that was a much more promising approach.) As she stated in a previous interview, very difficult to get funding for cell culturing. Drugs that are already approve that show somewhat hope are more likely to get funded. The cell culturing is still a crap shoot. Hopeful but not there yet. superhl is located in [NA] and he is available to meet: NO |
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RiuraO![]() Spain, 28.10.2015, 13:18 @ superhl |
JAK inhibitors grow hair - Dr. Christiano |
I am not an expert, but it seems that molecular size makes possible a dermal administration of the drug without any problem..... Any volunteer ? |
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jarjarbinx 29.10.2015, 04:00 @ RiuraO |
JAK inhibitors grow hair - Dr. Christiano |
I don't know much about this avenue of hair loss research but I do know that you will need specific information before doing a DIY experiment with a drug. We need to know what the drug is soluble in and we need to know the correct dose to use. |
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Dogstar 29.10.2015, 11:00 (edited by Dogstar, 29.10.2015, 11:43) @ jarjarbinx |
JAK inhibitors grow hair - Dr. Christiano |
I don't think we're going to get anywhere just slapping this stuff on our scalps and hoping for the best, like DR. Christiano said, |
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ESP2![]() 29.10.2015, 19:49 @ jarjarbinx |
JAK inhibitors grow hair - Dr. Christiano |
Agreed, but hard not to wonder if the getfitinib or another similar protocol (including the wounding and time-window for topical application) that some guys tried a couple of years ago would work with these drugs if the right mixture could be figured out. |
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roger_that MARYLAND, 30.10.2015, 22:00 @ Christopher1 |
Reason for baldness in these mice? |
Anyone know what the cause of the baldness was in the mice in these photos? |
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cal 30.10.2015, 23:35 @ roger_that |
Reason for baldness in these mice? |
Agreed, but hard not to wonder if the getfitinib or another similar protocol (including the wounding and time-window for topical application) that some guys tried a couple of years ago would work with these drugs if the right mixture could be figured out. It very well might work. But IIRC Gefintib isn't cheap without an insurance company picking up the check. I think at least one of the guys playing with a few years ago it was taking grapefruit juice at the time just to artificially jack up its effectiveness (liver) to hold down the expense of a steady internal dose for a few weeks. I'm about ready to declare the UVB sunburn as a necessary component. Swisstemples is using it. The Gefitnib patients both had regrowth in locations/patterns that looked like common sunburn possibilities, and there was no other obvious explanation for what their patterns were. They had not been trying to regrow hair when it happened to them. I haven't written off dermbrasion working too but I think the evidence is mounting for the role of a UVB burn. On that note, the Gefitnib patients were probably not re-burning exactly those same areas consistently for months on end. Yet their regrowth looked quite thick & dark. I suspect if we really nailed down this protocol then any sunburning required might only need to happen once or twice. Follica seemed to have settled on plucking a bunch of hairs (vellus is okay) from the wound area about 2-3 days beforehand. That might help boost results. cal is located in [NA] and he is available to meet: NO |
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roger_that MARYLAND, 31.10.2015, 13:15 @ jarjarbinx |
JAK inhibitors grow hair - Dr. Christiano |
Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist. |
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jarjarbinx 01.11.2015, 19:02 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
![]() Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist. I don't think you can get a pharmacist in the civilized world to do this. Also, when I said that science first needs to find out what dose produces the desired effect what I meant was that scientists would use a piece of detached human skin or human skin grafted to mice and apply the topicalized (liquid) version of the drug to it. The scientists would be looking to see what dose effectively blocks the enzymes they're trying to block, and they would be watching what effect doing so has on the human follicles inside the skin. This would involve biopsies and stuff like that. I'm talking about pre-clinical basic science. I don't think you're going to get a pharmacist in the civilized world to do what you're suggesting until more basic science is performed with this treatment concept. jarjarbinx is located in [NA] and he is available to meet: NO |
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roger_that MARYLAND, 01.11.2015, 22:41 @ jarjarbinx |
JAK inhibitors grow hair - Dr. Christiano |
![]() Good points. One idea might be for everyone to kick in $100-200 each, and find an experienced PhD pharmacist who could study these compounds' chemistry, solubility, and absorption profiles and come up with the best topical formulation, vehicle, etc. for a few thousand dollars. The actual mixing of the formulation would be left to the individual volunteer self-testers, or the vendor, so as not to create any potential liability for the pharmacist. ![]() I don't think you can get a pharmacist in the civilized world to do this. Also, when I said that science first needs to find out what dose produces the desired effect what I meant was that scientists would use a piece of detached human skin or human skin grafted to mice and apply the topicalized (liquid) version of the drug to it. The scientists would be looking to see what dose effectively blocks the enzymes they're trying to block, and they would be watching what effect doing so has on the human follicles inside the skin. This would involve biopsies and stuff like that. I'm talking about pre-clinical basic science. I don't think you're going to get a pharmacist in the civilized world to do what you're suggesting until more basic science is performed with this treatment concept. Jarjar -- I understand what you're saying. This was just a suggestion for a "quick and dirty" approach to getting this stuff tested as soon as possible, even if the testing is somewhat risky and may not yield results as accurate and reliable as we want. It seems you're always looking ways we can get things done fast, with minimal waiting and expense, so I just thought I'd throw the idea out there as a suggestion. I totally agree that few pharmacists in the "civilized world" might want to do this, but these days you never know. We could even get someone in Russia, Eastern Europe, China, etc., where people are much less worried about lawsuits, but places that still have some well-trained lab scientists and pharmacists/pharmacologists. Just an idea. As for your suggestion, yes, I realize that would be the way to go, but again, waiting for someone to do in vitro skin testing, biopsies, etc., will take a long time. I assume Dr. Christiano's on this, but who knows how long it'll be before she publicly comes out with some results? 6 months? A year? Who knows? It's not likely to be very soon, though. She'll have to get funding squared away, and will likely only announce results in a formal journal article, which will take many months if not more than a year to complete. roger_that is located in MARYLAND and he is available to meet: YES email hairsite@aol.com to arrange a meeting. |
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James Bond 02.11.2015, 18:42 @ roger_that |
JAK inhibitors grow hair - Dr. Christiano |
Based on the rate of progression of her other research, I estimate it will take her about 5 years to figure out if it works safely on MPB patients. Add in another 10 years of screwing around with the FDA and other entities before it's released as a cure. (If this seems like a long time to you, keep in mind that all involved will need at least 10 years factored in just to sit around on their fat asses.) |
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ESP2![]() 03.11.2015, 03:45 @ James Bond |
JAK inhibitors grow hair - Dr. Christiano |
JB: |
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jarjarbinx 04.11.2015, 07:13 @ ESP2 |
JAK inhibitors grow hair - Dr. Christiano |
![]() JB: A few questions: -what side effects would you anticipate? -how many test subjects? -any idea of the ballpark costs that would need to be raised? We could probably get info about what the stuff is soluble in but how will you figure out what dose (%) you will use? For example, minoxidil is 5%. How will you determine what % you need in order to block the enzymes in the scalp that you want to block? jarjarbinx is located in [NA] and he is available to meet: NO |
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News 05.11.2015, 20:49 @ James Bond |
JAK inhibitors grow hair - Dr. Christiano |
If it takes them 25 years to develop this treatment, they needn't worry about the side effects, because by then Sanford-Burnham's stem cell treatment will (probably) be on the market, and no one's going to use a topical treatment.... |