Wnt Activator Promotes Hair Growth
WNT Signaling Hair Regeneration
Recent studies suggest that WNT signaling activity may play an important role in hair cell specification, development and cycle regeneration.
WNT represents wingless-type MMTV (mouse mammary tumor virus) integration site. Wnt signaling regulates stem cell activity as a proliferative and self-renewal signal.
DKK-1 Inhibits WNT Signaling Pathway
In a study published in the Journal of Investigative Dermatology, Kwack MH et al indicated that a higher than normal level of androgen-inducible Dickkopf-1 (DKK-1) protein have been found in biopsies of scalp skin taken from balding men. It is suggested and later proven in mice study that DKK-1 inhibits Wnt signaling pathway and, consequently, stem cell division; resulting in a shortening of the growth cycle or anagen phase of hair follicles.
Dr. Mark V. Dahl who has reviewed Kwach MH et al's study further reiterated that stem cells and proper Wnt pathway signaling facilitate normal hair growth. In addition, certain Wnt proteins, such as Wnt10b, have been shown to promote hair follicle growth in organ culture.
WNT Activator Hair Growth Trial Results
WNT activator promotes hair growth in humans? The latest and most groundbreaking Wnt hair growth study was published in the Journal of Cosmetic Dermatology. In the clinical trial, the plant extract Methyl Vanillate was used as an activator for Wnt/B-catenin pathway. A total of 20 female test subjects, age 25-57 with varying degrees of androgenetic alopecia or female pattern baldness participated in the study. The product used in the trial was a topical formula containing 0.2% Methyl Vanillate as active ingredient.
The study lasted 6 months and scalp biopsies were taken to evaluate the results. No side effects were reported during the study. Overall hair count and hair mass index increased by 6% and 12% respectively among the test subjects. Biopsies also reveal that a 32% increase in WNT10B mRNA expression levels in the temporal scalp area which is considered quite substantial.
The study further concludes that topical Methyl Vanillate formula can increase hair count and hair mass index by inducing Wnt pathway signaling expression in the scalp, potentially serving as a new treatment for hair loss or pattern baldness.
WNT Activator Containing Methyl Vanillate
At the time when this editorial is published, the only WNT activator formula using Methyl Vanillate as active ingredient is WNT Act as promoted by Dr. Cole's hair clinic. According to Dr. John Cole, WNT-Act is the first product to attack hair loss at the gene level by upregulating WNT and downregulating DKK1. WNT-Act is a topical plant based topical product formulated based on studies conducted by by Dr. Antonella Tosti at the University of Miami.
Unfortunately, as exciting as it may sound, we have not heard of any positive reviews of WNT Activator till this date. Buyers beware.
Of course, there is no one product that works for all types of hair loss in men and women. WNT-Act may help hair loss sufferers to a certain extent but users are advised that this product alone is unlikely to regrow hair for most people which seems to be the case based on our anecdotal evidence.
This is potentially another case of valid research accompanied by a failed product; a disconnect between the product itself and the research behind the product.
If you have used WNT Activator with success, please do share with us in our forum.
More Info on WNT Hair Growth Products?
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