Lactate Influences Hair Follicle Stem Cells
New study suggests that Lactate may influence hair follicle stem cells in a dose dependent manner.
What is Lactate?
Lactate regulates human metabolism. It is commonly regarded as a waste product as a result of exercise that may have an effect on muscle soreness. Lactate is known for being able to stimulate collagen synthesis and vessel growth. Lately it has been shown that lactate, in vivo, may have a role to play in the proliferation of stem cells.
Lactate, Hair Follicle Stem Cells Connection
Recently, Lactate has become a popular topic in our community. Some believe that there might be a connection between Lactate and Hair Follicle Stem Cells.
Some research scientists at UCLA found a big difference between lactate levels in mouse skin between hairless mice and mice with hair, particularly inside the Hair Follicle Stem Cells (HFSCs). The HFSCs in the hairy mice were activated; the ones in the hairless mice were dormant.
How Does Lactate Work?
When you ingest food that contains glucose (simple sugar), it gets broken down in the body's metabolic cycle and changed to other molecules. Some of it becomes pyruvate which goes to the mitochondria -- little mini-organs inside your cells -- and from there it makes energy for the cells (like, for your muscles). Another thing that can happen to the pyruvate molecule is, it doesn't go to the mitochondria for energy production, but instead it can be converted into lactate. (Lactate is the same chemical that builds up in your muscles after strenuous exercise and makes them feel tired.)
Hair Follicle Stem Cells Lactate Levels
If the Hair Follicle Stem Cells (HFSCs) have a lot of lactate in them, apparently they become activated and start making hair. If they have low levels of lactate, or no lactate, they become dormant and do nothing -- at least that's what the UCLA scientists found in their study. This is analogous with what they think happens in balding people.
UK5099 Initiates Lactate and Hair Follicle Stem Cells?
As reported in our forum community, a drug called UK5099 is now available for sale on the market. The specualtion is whether if you can add this drug, UK5099 (or the other drug they found), by applying it topically, perhaps it will increase lactate levels in the HFSCs, and revive the miniaturized follicles in people with male pattern baldness.
Lactate Hair Follicle Stem Cells Forum Discussion
The above is an excerpt from the discussions in our open forum on this topic. To read more on this topic or to participate in the discussion, please click Lactate Hair Follicle Stem Cells.
Looking for Treatment Now?
The discussion of Lactate and Hair Follicle Stem Cells is still very preliminary and most speculative in nature. We do not recommend anyone go out and self medicate in order to test the efficacy of Lactate and its effect on Hair Follicle Stem Cells proliferation.
It will be many years and require a lot more clinical studies before we can draw any conclusions whether Lactate levels affect Hair Follicle Stem Cells.
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